ABSTRACT
Mycetoma is a neglected tropical disease with an unknown global burden. Although considered endemic to South-east Asia, it has not previously been reported from Timor-Lest. We describe two cases in Timor-Leste, highlighting the challenges surrounding microbiological diagnosis and management shared by many low to middle-income countries. As characteristically described, both patients lived rurally and presented late with marked soft tissue involvement and multiple draining sinuses following a prolonged period of high morbidity. Nocardia brasiliensis, a beadedbranched, modified acid-fast, gram-positive bacilli, was isolated and confirmed by molecular testing in the first case. The causative organism in the second case could not be confirmed due to limited microbiological capabilities. Due to limited local laboratory capabilities, Nocardia spp. infection cannot be routinely confirmed in Timor- Leste. However, the microbiology laboratory is essential for the successful diagnosis and management of Mycetoma. In both cases, medical therapy alone resulted in cure and favorable outcomes, although supply of antibiotic remains an ongoing resource issue.
ABSTRACT
BACKGROUND: Limited data regarding prevalence of hepatitis B virus infection in Timor-Leste exist. METHODS: An observational study of hepatitis B surface antigen (HBsAg) results of women delivering at Bairo Pite Clinic in Dili, Timor-Leste was carried out. RESULTS: Of the 781 women included in the study, 80.5% (626/777) of women who had accessed antenatal care had been tested for HBsAg, of whom 2.2% (14/626) were positive. Of the remaining women, 83.2% (129/155) received a test at the time of delivery, of whom 5.4% (7/129) were positive. Overall prevalence of HBsAg positivity was 2.8% (21/755). CONCLUSIONS: Further studies are urgently needed to establish the prevalence of HBV infection in Timor-Leste, particularly in pregnant women. Findings from this study suggest that routine HBV immunisation of newborns should be instituted promptly.
