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1.
HIV Med ; 16(10): 640-4, 2015 Nov.
Article in English | MEDLINE | ID: mdl-25958770

ABSTRACT

OBJECTIVES: The World Health Organization (WHO) recommends screening HIV-infected people for cryptococcal antigens to identify cryptococcosis, a major cause of AIDS-related deaths. As the burden of cryptococcosis is unknown in South Africa's KwaZulu-Natal province, we assessed the cryptococcal antigenuria prevalence among newly diagnosed HIV-infected adults there. METHODS: We conducted a cross-sectional study of newly diagnosed HIV-infected adults who received voluntary HIV testing in an out-patient clinic. Participants provided a urine specimen in a sterile container, and we performed testing with a WHO-endorsed rapid cryptococcal antigen lateral flow assay (Immy Inc., Norman, OK, USA) per the manufacturer's specifications. We assessed cryptococcal antigenuria prevalence among participants with CD4 counts < 200 cells/µL, and stratified results by CD4 count categories. RESULTS: Among 432 participants, the mean (± standard deviation) age was 36.1 ± 9.9 years and 172 (40%) were female. The overall estimated prevalence of cryptococcal antigenuria was 9.0% [95% confidence interval (CI) 6.5-12.1%]. CD4 counts were available for 319 participants (74%); the median CD4 count was 75 cells/µL [interquartile range (IQR) 34-129 cells/µL]. Participants with a negative cryptococcal antigenuria screening test had a median CD4 count of 79 cells/µL (IQR 36-129 cells/µL), while participants with a positive cryptococcal test had a median CD4 count of 41 cells/µL (IQR 10-112 cells/µL). The estimated prevalence of cryptococcal antigenuria among participants with CD4 counts < 50 cells/µL was 12.5% (95% CI 7.0-20.1%), which was significantly higher than that among participants with CD4 counts of 50-200 cells/µL (4.8%; 95% CI 2.3-8.7%). CONCLUSIONS: Nearly 1 in 10 newly diagnosed HIV-infected adults with CD4 counts < 200 cells/µL in KwaZulu-Natal had evidence of cryptococcal antigenuria. Point-of-care CD4 count testing and cryptococcal antigen screening may rapidly identify cryptococcosis at the time of HIV diagnosis.


Subject(s)
AIDS-Related Opportunistic Infections/epidemiology , Antigens, Fungal/urine , Cryptococcosis/epidemiology , Cryptococcus/isolation & purification , HIV Infections/complications , Adult , Antigens, Fungal/blood , CD4 Lymphocyte Count , Cross-Sectional Studies , Cryptococcosis/diagnosis , Cryptococcosis/urine , Cryptococcus/immunology , Female , Humans , Male , Middle Aged , Prevalence , Risk Factors , South Africa/epidemiology
2.
Infect Dis Obstet Gynecol ; 2012: 146348, 2012.
Article in English | MEDLINE | ID: mdl-22927713

ABSTRACT

BACKGROUND: Understanding HIV-infected patient experiences and perceptions of reproductive counseling in the health care context is critical to inform design of effective pharmaco-behavioral interventions that minimize periconception HIV risk and support HIV-affected couples to realize their fertility goals. METHODS: We conducted semistructured, in-depth interviews with 30 HIV-infected women (with pregnancy in prior year) and 20 HIV-infected men, all reporting serodiscordant partners and accessing care in Durban, South Africa. We investigated patient-reported experiences with safer conception counseling from health care workers (HCWs). Interview transcripts were reviewed and coded using content analysis for conceptual categories and emergent themes. RESULTS: The study findings indicate that HIV-infected patients recognize HCWs as a resource for periconception-related information and are receptive to speaking to a HCW prior to becoming pregnant, but seldom seek or receive conception advice in the clinic setting. HIV nondisclosure and unplanned pregnancy are important intervening factors. When advice is shared, patients reported receiving a range of information. Male participants showed particular interest in accessing safer conception information. CONCLUSIONS: HIV-infected men and women with serodiscordant partners are receptive to the idea of safer conception counseling. HCWs need to be supported to routinely initiate accurate safer conception counseling with HIV-infected patients of reproductive age.


Subject(s)
Contraception/psychology , Counseling/methods , HIV Infections/psychology , Health Personnel/psychology , Pregnancy Complications, Infectious/psychology , Adolescent , Adult , Attitude to Health , Counseling/standards , Female , HIV Seropositivity , Humans , Male , Middle Aged , Pregnancy , Pregnancy Complications, Infectious/prevention & control , Sexual Partners , Socioeconomic Factors , South Africa , Young Adult
3.
S Afr Med J ; 101(9): 645-50, 2011 Sep 05.
Article in English | MEDLINE | ID: mdl-21920157

ABSTRACT

BACKGROUND: Obesity and undernutrition are common in South Africa and influence the health outcomes of people living with the human immunodeficiency virus (PLHIV). AIM: To describe the anthropometric changes and perceptions of body weight in adults initiated on antiretroviral therapy (ART). METHODS: A cohort of 230 PLHIV was enrolled at an HIV clinic in Durban. Changes in their body mass index, and waist and hip girth were measured 6-monthly in the 12 months following initiation of ART. Data on demographic and socio-economic variables, CD4 counts, opportunistic infections and drug regimens used were recorded. Perceptions of body weight and desire to change these were ascertained. RESULTS: Weight perceptions of respondents were incongruent with their body mass index, with the trend being to judge themselves as weighing less than their actual weight. Those wanting to gain weight gained an average of 7.8 kg - 2.8 times more than those satisfied with their weight (p<0.001). After 12 months on ART, there was a statistically significant increase in anthropometric measurements (p<0.001) with 43 of the 110 women having waist circumferences that increased their risk of cardiovascular disease; the incidence of lipodystrophy was 35% (62/177) (95% confidence interval 27-42%), 36% (64/177) were overweight and 22% (39/177) were obese, compared with 21% (49.230) and 12% (28/230) respectively at baseline (p=0.002). CONCLUSION: There is a strong association between PLHIV's perception of body weight, their desire to gain weight and their actual weight gain on ART. Lipodystrophy, weight gain and truncal obesity are common among PLHIV after initiating ART.


Subject(s)
Anti-Retroviral Agents/therapeutic use , Body Weight , HIV Infections/drug therapy , Adult , Body Mass Index , Comorbidity , Female , Humans , Lipodystrophy/epidemiology , Male , Malnutrition/epidemiology , Obesity/epidemiology , South Africa , Waist Circumference , Waist-Hip Ratio , Weight Gain
4.
HIV Med ; 12(1): 46-53, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20553336

ABSTRACT

BACKGROUND: The yield of screening for acute HIV infection among general medical patients in resource-scarce settings remains unclear. Our objective was to evaluate the strategy of using pooled HIV plasma RNA to diagnose acute HIV infection in patients with negative or discordant rapid HIV antibody tests in Durban, South Africa. METHODS: We prospectively enrolled patients with negative or discordant rapid HIV antibody tests from a routine HIV screening programme in an out-patient department in Durban with an HIV prevalence of 48%. Study participants underwent venipuncture for pooled qualitative HIV RNA, and, if this was positive, quantitative RNA, enzyme immunoassay and Western blot (WB). Patients with negative or indeterminate WB and positive quantitative HIV RNA were considered acutely infected. Those with chronic infection (positive RNA and WB) despite negative or discordant rapid HIV tests were considered to have had false negative rapid antibody tests. RESULTS: Nine hundred and ninety-four participants were enrolled with either negative (n=976) or discordant (n=18) rapid test results. Eleven [1.1%; 95% confidence interval (CI) 0.6-2.0%] had acute HIV infection, and an additional 20 (2.0%; 95% CI 1.3-3.1%) had chronic HIV infection (false negative rapid test). CONCLUSIONS: One per cent of out-patients with negative or discordant rapid HIV tests in Durban, South Africa had acute HIV infection readily detectable through pooled serum HIV RNA screening. Pooled RNA testing also identified an additional 2% of patients with chronic HIV infection. HIV RNA screening has the potential to identify both acute and chronic HIV infections that are otherwise missed by standard HIV testing algorithms.


Subject(s)
AIDS Serodiagnosis/methods , HIV Infections/epidemiology , HIV Seroprevalence , HIV-1/immunology , Mass Screening/methods , RNA, Viral/blood , Acute Disease , Adult , Algorithms , Ambulatory Care , Blotting, Western , Chronic Disease , False Negative Reactions , Female , HIV Infections/blood , HIV Infections/diagnosis , Humans , Immunoenzyme Techniques , Male , Middle Aged , Predictive Value of Tests , Pregnancy , Prospective Studies , Reagent Kits, Diagnostic , South Africa/epidemiology
5.
Philos Trans A Math Phys Eng Sci ; 367(1897): 2607-17, 2009 Jun 28.
Article in English | MEDLINE | ID: mdl-19451114

ABSTRACT

We report on the RTGrid project, which investigates approaches for using high-performance computing infrastructures, such as the grid, in order to reduce the turnaround time of Monte Carlo (MC) simulation-based radiotherapy treatment planning. The main aim of this project is to render accurate dose calculations using MC simulations clinically feasible. To this end, we have successfully implemented and deployed the RTGrid distributed simulation framework for MC dose calculations. In this paper, we present the main experimental findings.


Subject(s)
Computer Communication Networks/statistics & numerical data , Radiotherapy Planning, Computer-Assisted/statistics & numerical data , Humans , Monte Carlo Method , Neoplasms/radiotherapy , Time Factors , United Kingdom
6.
HIV Med ; 9(10): 863-7, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18754802

ABSTRACT

BACKGROUND: Routine HIV testing is increasingly recommended in resource-limited settings. Our objective was to evaluate factors associated with a new diagnosis of HIV infection in a routine HIV testing programme in South Africa. METHODS: We established a routine HIV testing programme in an out-patient department in Durban, South Africa. All registered adults were offered a rapid HIV test; we surveyed a sample of tested patients. RESULTS: During the 12-week study, 1414 adults accepted HIV testing. Of those, 463 (32.7%) were HIV-infected. Seven hundred and twenty (50.9%) were surveyed. Compared with married women, unmarried men were at the highest risk of HIV [odds ratio (OR) 6.84; 95% confidence interval (CI) 3.45-23.55], followed by unmarried women (OR 5.90; 95% CI 3.25-10.70) and married men (OR 4.00; 95% CI 2.04-7.83). Age 30-39 years (compared with >or=50 years; OR 5.10; 95% CI 2.86-9.09), no prior HIV test (OR 1.45; 95% CI 1.07-2.27) and an imperfect HIV knowledge score (OR 2.32; 95% CI 1.24-4.35) were also associated with HIV infection. CONCLUSION: In a routine HIV testing programme in South Africa, rates of previously undiagnosed HIV were highest among men, young and unmarried patients, and those with poorer HIV knowledge. Better interventions are needed to improve HIV knowledge and decrease HIV risk behaviour.


Subject(s)
HIV Infections/diagnosis , HIV-1 , Patient Acceptance of Health Care/statistics & numerical data , Adolescent , Adult , Ambulatory Care , CD4 Lymphocyte Count , Female , Health Knowledge, Attitudes, Practice , Humans , Male , Risk Factors , South Africa , Urban Health , Young Adult
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