ABSTRACT
We report three cases of erosive oral lichen planus treated with griseofulvin, 500 mg. twice a day. Subjective improvement was noticed in 3 weeks by two patients and at 6 weeks by the third patient. Objective improvement, however, was delayed and became apparent at 6 to 10 weeks. Continued improvement or remission without exacerbation was noted in all patients. There were no significant hematologic, hepatic, or other side effects in any patient, and complete blood count and blood chemistries remained normal at 1-month as well as 6-month intervals during therapy. All patients did, however, report mild, transient gastrointestinal discomfort during the first 2 days of therapy, and one patient mentioned a mild headache. These remitted after approximately 2 to 4 days. We believe that these preliminary findings warrant additional trials of griseofulvin therapy in the treatment of severely symptomatic oral lichen planus. The adverse effects of this agent appear considerably less than those of systemic steroids.
Subject(s)
Griseofulvin/therapeutic use , Lichen Planus/drug therapy , Mouth Diseases/drug therapy , Aged , Female , Humans , Lichen Planus/pathology , Middle Aged , Mouth Diseases/pathology , Time FactorsABSTRACT
Solutions of liquid detergent products were used to induce emesis in 15 patients who could not or would not obtain syrup of ipecac. Four patients refused to drink any of the solution and two others refused part, one of whom vomited. In the patients who drank all or part of the solution, 91% (10/11) vomited with a mean time to the onset of emesis of 6.5 min. None of these patients developed symptoms attributable to the ingested poison or the detergent solution. Liquid detergent solutions may be a useful alternative emetic for the poison center when a patient cannot be given syrup of ipecac.
