ABSTRACT
INTRODUCTION: Discordance between real-world prescribing patterns and global treatment guidelines for the treatment of chronic obstructive pulmonary disease (COPD) with inhaled single or dual long-acting bronchodilator maintenance therapy is increasingly being reported in the literature, particularly with regard to addition of inhaled corticosteroids (ICS). Patient-related factors, e.g. inhalation technique and inspiratory flow, are key to disease control in COPD. Treatment discordance and patient-related factors can lead to high-cost side effects and sub-optimal treatment benefit; furthermore, the COVID-19 pandemic has led to new challenges in COPD management. AREAS COVERED: This article summarizes a series of presentations sponsored by Boehringer Ingelheim and delivered at the annual CHEST congress 2021 (October 17-20, 2021) that explored new insights into the optimal management of COPD. EXPERT OPINION/COMMENTARY: There is a concerning high degree of discordance with GOLD recommendations. Dual therapy without addition of ICS does not increase exacerbation risk and could reduce pneumonia risk, and unnecessary prescription of triple therapy has financial implications. Clinic-based spirometry may not reflect the home setting, and training is required; inhalers that operate independently of users' inhalation profiles should be considered. Integration of digital healthcare solutions into clinical studies is suggested in the post-COVID setting, although further evaluation is required.
Subject(s)
COVID-19 Drug Treatment , Pulmonary Disease, Chronic Obstructive , Administration, Inhalation , Adrenal Cortex Hormones/therapeutic use , Adrenergic beta-2 Receptor Agonists , Bronchodilator Agents/therapeutic use , Drug Therapy, Combination , Humans , Muscarinic Antagonists/therapeutic use , Pandemics , Plant Extracts/therapeutic use , Pulmonary Disease, Chronic Obstructive/diagnosis , Pulmonary Disease, Chronic Obstructive/drug therapy , Pulmonary Disease, Chronic Obstructive/epidemiologyABSTRACT
The authors report a case of inferior vena cava filter arm perforation, followed by fracture and migration to the right ventricle causing chest pain and nonsustained ventricular tachycardia. Review of abdominal computed tomographic (CT) scans show the two filter arms that fractured and migrated had perforated the vena cava 2 years previously. Microscopic evaluation of the retrieved filter and limbs revealed bending metal fatigue at the fracture sites. This case and review of the literature suggest a causal relation between Bard Recovery filter arm perforation and subsequent fracture and migration. Percutaneous retrieval of filters with arm fracture or arm migration is recommended.
