Mesenchymal Stem Cells from COPD Patients Are Capable of Restoring Elastase-Induced Emphysema in a Murine Experimental Model.

COPD is a chronic lung disease that affects millions of people, declining their lung function and impairing their life quality. Despite years of research and drug approvals, we are still not capable of halting progression or restoring normal lung function. Mesenchymal stem cells (MSC) are cells with extraordinary repair capacity, and MSC-based therapy brings future hope for COPD treatment, although the best source and route of administration are unclear. MSC from adipose tissue (AD-MSC) represents an option for autologous treatment; however, they could be less effective than donor MSC. We compared in vitro behavior of AD-MSC from COPD and non-COPD individuals by migration/proliferation assay, and tested their therapeutic potential in an elastase mouse model. In addition, we tested intravenous versus intratracheal routes, inoculating umbilical cord (UC) MSC and analyzed molecular changes by protein array. Although COPD AD-MSC have impaired migratory response to VEGF and cigarette smoke, they were as efficient as non-COPD in reducing elastase-induced lung emphysema. UC-MSC reduced lung emphysema regardless of the administration route and modified the inflammatory profile in elastase-treated mice. Our data demonstrate equal therapeutic potential of AD-MSC from COPD and non-COPD subjects in the pre-clinical model, thus supporting their autologous use in disease.

Sestamibi Scintigraphy & Video-assisted Thoracoscopic (VATS) Resection of Mediastinal Parathyroid adenomatosis: Surgical Technique & Case Report

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Cirugía toracoscópica monoportal utilizando el instrumento SILS(R) como un método novedoso en el tratamiento quirúrgico del neumotórax / Single Port Thorascopic Surgery Using the SILS(R) Tool as a Novel Method in the Surgical Treatment of Pneumothorax

La single incision laparoscopic surgery (SILS, ‘cirugía laparoscópica a través de incisión única’) ha sido recientemente utilizada por cirujanos generales para realizar colecistectomías y reparación de hernias preperitoneales con malla mediante cirugía de minima invasión diminuyendo así el dolor postoperatorio y obteniéndose un resultado más cosmético de la cirugía. Describimos los primeros casos de cirugía torácica videoasistida en neumotórax espontáneos utilizando el sistema SILS. No hay reportes previos del uso del SILS en cirugía torácica videoasistida para el neumotórax espontáneo. Este sistema además de permitirnos obtener un resultado quirúrgico más cosmético, también disminuye la estancia media postoperatoria y la necesidad de analgésicos a fin de reducir el dolor postoperatorio(AU)

Single Incision Laparoscopic Surgery (SILS) has recently been used by general surgeons to perform cholecystectomies and pre-peritoneal hernia repairs with mesh using minimally invasive surgery, thus decreasing post-operative pain and a more cosmetic result of the surgery being obtained. We describe the first cases of video-assisted thoracic surgery (VATS) in spontaneous pneumothorax using the SILS system. There are no previous reports on the use of the SILS system in VATS for spontaneous pneumothorax. This system also allows us to obtain a more cosmetic surgical result, as well as decreasing the mean post-operative hospital stay and the need for analgesics to improve the post-operative pain(AU)

[Single port thorascopic surgery using the SILS tool as a novel method in the surgical treatment of pneumothorax]. / Cirugía toracoscópica monoportal utilizando el instrumento SILS como un método novedoso en el tratamiento quirúrgico del neumotórax.

Single Incision Laparoscopic Surgery (SILS) has recently been used by general surgeons to perform cholecystectomies and pre-peritoneal hernia repairs with mesh using minimally invasive surgery, thus decreasing post-operative pain and a more cosmetic result of the surgery being obtained. We describe the first cases of video-assisted thoracic surgery (VATS) in spontaneous pneumothorax using the SILS system. There are no previous reports on the use of the SILS system in VATS for spontaneous pneumothorax. This system also allows us to obtain a more cosmetic surgical result, as well as decreasing the mean post-operative hospital stay and the need for analgesics to improve the post-operative pain.