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Bioorg Med Chem Lett
; 25(24): 5694-8, 2015 Dec 15.
Article
in English
| MEDLINE
| ID: mdl-26547691
ABSTRACT
A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.