1.
Org Biomol Chem
; 10(1): 67-9, 2012 Jan 07.
Article
in English
| MEDLINE
| ID: mdl-22027866
ABSTRACT
A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.
Subject(s)
Alkaloids/chemical synthesis , Spiro Compounds/chemical synthesis
2.
Org Biomol Chem
; 7(11): 2274-7, 2009 Jun 07.
Article
in English
| MEDLINE
| ID: mdl-19462035
ABSTRACT
Two-directional cross-metathesis of a range of alpha,omega dienes with a variety of electron deficient alkenes has been accomplished. It was found that the process is quite general and gives complete selectivity for the E,E-dienes, making this a very useful and high yielding protocol for two-directional chain elongation.
