ABSTRACT
The paper describes specific correlation of the clinical and molecular pathogenic features in various types of combined periapical lesions. Endodontic apical lesions combined with periodontal disease are characterized by specific radiological signs, shifts in oral fluid physical and chemical properties, the disruption of nitrogen metabolism, increased iron concentration, collagen disruption and impaired concentration ratio of calcium and phosphorous. General depression of immunoglobulin synthesis and increased concentration of cortisol and estradiol in oral fluid are also typical features of combined periapical lesions.
Subject(s)
Periapical Periodontitis/diagnosis , Calcium/analysis , Chronic Disease , Diagnosis, Differential , Estradiol/analysis , Female , Humans , Hydrocortisone/analysis , Immunoglobulins/analysis , Immunoglobulins/biosynthesis , Male , Periapical Periodontitis/diagnostic imaging , Periapical Periodontitis/metabolism , Periodontium/immunology , Periodontium/metabolism , Phosphorus/analysis , Radiography , Saliva/chemistry , Saliva/metabolismABSTRACT
Interrelationships between parameters of humoral immunity with AB0 blood groups have been investigated. The highest content of IgA to transglutaminase was found in A(II) patients, while the lowest content was found in AB(IV) patients. The blood content on anti-gliadin IgA was higher in healthy donors. The oral liquid of periodontic patients contained anti-gliadin IgA and IgB lacking in healthy donors. It have been found that 47% of healthy people and 52.7% of patients are infcted with Helicobacter pylori. In the group of periodontic patients A(II) individually predominated; they were characterized by the presence of antibodies to H. pylori in the oral liquid, these antibodies were absent in healthy donors. The pepsinogen level was higher in blood of periodontic patients than in healthy donors. B(III) patients had the lowest level of blood pepsinogen.
Subject(s)
ABO Blood-Group System , Chronic Periodontitis/blood , Chronic Periodontitis/immunology , Immunity, Humoral , Adult , Chronic Periodontitis/enzymology , Chronic Periodontitis/microbiology , Female , Gliadin/immunology , Helicobacter Infections/enzymology , Helicobacter Infections/immunology , Helicobacter Infections/microbiology , Helicobacter pylori/immunology , Humans , Immunoglobulin A/blood , Immunoglobulin A/immunology , Immunoglobulin G/blood , Immunoglobulin G/immunology , Male , Phenotype , Saliva/immunology , Transglutaminases/immunology , Young AdultABSTRACT
As the result of clinical-lab study of 40 oral fluid parameters in 176 patients new block of data was received disclosing key pathogenetic links of chronic generalized parodontitis (CGP) to which could be attributed endocrine dysfunction with cortisol level reduction and free thyroid hormones increase, enforcing prooxidant processes with multiple iron content increase. As the result of it molecules of medium mass were accumulated; protein spectrum, protein coupling capacity, content of collagenous C-peptide, osteocalcine, Ca, P and Mg were changing. In comprehensive CGP treatment due to Natursyl (lipophilic fraction of holy thistle) applications the disease clinical signs disappeared quicker and biochemical markers normalized.
Subject(s)
Databases, Factual , Hormones/metabolism , Periodontal Diseases/epidemiology , Periodontal Diseases/metabolism , Chronic Disease , Humans , Mouth , Periodontal Diseases/diagnosis , Severity of Illness IndexABSTRACT
The parameters of oral homeostasis were studied in patients with acute pneumonia before and after therapy. The redox potential, a shift of pH towards the acid values, decreased content of total protein, total and effective concentrations and reserve of albumin binding, and a drastic increase of toxicity index were detected. Analysis of oral fluid showed increased level of ionized calcium, nitrate anion, and decreased content of magnesium and ammonium cations.
Subject(s)
Pneumonia/metabolism , Saliva/chemistry , Acute Disease , Adolescent , Adult , Dental Caries/etiology , Dental Caries/metabolism , Female , Humans , Male , Pneumonia/complications , Saliva/metabolismABSTRACT
Parameters of homeostasis in the oral liquid during adentia, after implantation of titanium implants gated in generally accepted way and also with usage of natursilum from Silybum marianum were studied. Application of natursilum in surgery and in postoperative period promoted optimization of an implant osteointegration and normalized physicochemical and metabolic parameters of the oral liquid.
Subject(s)
Dental Implantation, Endosseous/methods , Mouth/drug effects , Mouth/metabolism , Phytotherapy , Plant Preparations/therapeutic use , Silybum marianum/chemistry , Adult , Body Fluids/metabolism , Female , Homeostasis , Humans , Male , Middle Aged , Mouth/surgery , Postoperative Care , Wound Healing/drug effectsABSTRACT
The outcomes, obtained in experiment, testify about high reparative ability of a natursilum. Natursilum has growth efficiency of conventional treatment of an ulcer of a stomach and duodenal intestine patients both on end results, and on terms of an adhesion increases. Is rotined, that natursilum has more expressed antiulcerous effect, than oil of hippopheae. The transendoscopy spraying of an ulcerative defect has not advantages before application of a drug inside. The specificity of a natursilum structure determines character of effect on exchange processes.
Subject(s)
Anti-Ulcer Agents/therapeutic use , Duodenal Ulcer/therapy , Phytotherapy , Silybum marianum , Stomach Ulcer/therapy , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
Influence of bioactive additions from natural vegetable raw materials--silybum marianum--in the content of bread products on health and metabolism was studied. It is shown bread products with silybum marianum to be effective medicine with general restorative influence, increasing internal protection resources, capacity for work and vital activity.
