Mitochondrial Variation of Bottlenose Dolphins (Tursiops truncatus) from the Canary Islands Suggests a Key Population for Conservation with High Connectivity within the North-East Atlantic Ocean.

In recent decades, worldwide cetacean species have been protected, but they are still threatened. The bottlenose dolphin (Tursiops truncatus) is a vulnerable keystone species and a useful bioindicator of the health and balance of marine ecosystems in oceans all over the world. The genetic structure of the species is shaped by their niche specialization (along with other factors), leading to the classification of two ecotypes: coastal and pelagic. In this study, the genetic diversity, population structure, and ecotypes of bottlenose dolphins from the Canary Islands were assessed through the analysis of 49 new samples from biopsies and from stranded animals using the 636 bp portion of the mitochondrial control region and 343 individuals from databases (n = 392). The results reveal high genetic diversity in Canarian bottlenose dolphins (Hd = 0.969 and π = 0.0165) and the apparent lack of population genetic structure within this archipelago. High genetic structure (Fst, Φst) was found between the Canary Islands and coastal populations, while little to no structure was found with the pelagic populations. These results suggest that Canarian bottlenose dolphins are part of pelagic ecotype populations in the North Atlantic. The studied Special Areas of Conservation in the Canary Islands may correspond to a hotspot of genetic diversity of the species and could be a strategic area for the conservation of the oceanic ecotype of bottlenose dolphins.

The discriminative, criterion, and longitudinal validity of small-sided games to assess physical fitness in female basketball players.

The validity of small-sided games (SSG) for assessing physical fitness was evaluated in 21 female basketball players from senior (n = 8), under-18 years (n = 6), and under-16 years (n = 7) age categories. Players underwent fitness testing (countermovement jump [CMJ], agility T-test, repeated-sprint ability (RSA) test, and Yo-Yo Intermittent Recovery Test [YYIRT1]) and 3vs3-SSG before and after a 6-week preseason. Player demands were monitored during SSG using local positioning system and heart rate technology. Regarding discriminative validity, senior players produced better CMJ, agility T-test, and YYIRT1 performance (p < 0.05, effect size [ES] = 1.72-2.25), and more distance and PlayerLoad (p < 0.05, ES = 1.53-2.47) during SSG than under-18 players following the preseason. For criterion validity, total distance and distance completing high-intensity decelerations during SSG were significantly (p < 0.05) correlated with CMJ (r = 0.44-0.66), YYIRT1 (r = 0.43-0.63), agility T-test (total distance only, r=-0.51), and RSA test performance (r=-0.49 to -0.52) among all players combined following the preseason. Regarding longitudinal validity, significantly better agility T-test and YYIRT1 performance (p ≤ 0.001, ES = 0.88-0.93) alongside lower heart rate during SSG (p = 0.001, ES = 0.88) were evident for all players combined following the preseason. These results partially support the validity of 3vs3-SSG to assess physical fitness in female basketball players.

Conclusiones de las XI Jornadas del Grupo Avilés sobre Medicina del Deporte 3 y 4 de Octubre de 2022 (Barcelona) / Conclusões da XI Conferência do Grupo Aviles de Medicina Esportiva, 3 e 4 de outubro de 2022 (Barcelona) / Conclusions of the XI Conference of the Aviles Group on Sports Medicine, October 3 and 4, 2022 (Barcelona)

El Grupo de Trabajo Avilés fue impulsado por el Consejo Superior de Deportes en 2009 y está formado por representantes de los Centros de Medicina dela Educación Física y el Deporte de todas las comunidades autónomas que cuentan con estas infraestructuras y representantes de centros de medicinadel deporte de centros de tecnificación, centros municipales de medicina del deporte y la Agencia Española de Protección de la Salud en el Deporte. Comoobjetivos de este grupo de trabajo figuran la coordinación entre estas estructuras autonómicas de la medicina del deporte, el planteamiento de solucionescomunes a las diferentes problemáticas que sufren cada uno de los centros y el ser un grupo de asesoramiento, en los diferentes ámbitos de la medicinade la educación física y el deporte, para el Consejo Superior de Deportes.Este grupo de trabajo se reúne periódicamente; en su última reunión, celebrada en Barcelona el 3 y 4 de octubre de 2022, se acordaron una serie deconclusiones, en relación a la muerte súbita y las arritmias en el deporte, el SARS Cov-2, la prevención, la salud mental, la diversidad sexual y laespecialidad MIR.(AU)

The Avilés Working Group was promoted by the National Sports Council in 2009 and is made up of representatives of Physical Education and SportsMedicine Centers of all the autonomous communities that have these infrastructures, Sports Technification Centers, municipal Sports Medicine Centersand the Spanish Agency for Health Protection in Sport. The objectives of this working group include the coordination between these autonomousstructures of Sports Medicine, the proposal of common solutions to the different problems suffered by each of the centers and to be an advisory group inthe different areas of the Physical Education and Sports Medicine, for the National Sports Council.This working group meets periodically; at its last online meeting, held in Barcelona on October 3-4, 2022, a series of conclusions were agreed in relationto sudden death and arrytmias in sport, SARS Cov-2, prevention, mental health, sexual diversity and the MIR specialty.(AU)

O grupo de Trabalho Avilés foi incentivado pelo Conselho Superior de Esportes em 2009. É composto por representantes dos Centros de Medicina daEducação Física e Esporte de todas as comunidades autônomas que contam com estas infraestruturas, bem como representantes dos centros de medicinado esporte de centros técnicos, centros municipais de medicina do esporte e da Agencia Espanhola de Proteção da saúde no Esporte. Como objetivos detrabalho desde grupo, figuram a coordenação entre estas estruturas autonômicas da medicina do esporte, a criação de soluções comuns as diferentesproblemáticas que sofrem cada um dos centros, além de ser um grupo de assessoramento, nos diferentes âmbitos da medicina da educação física e doesporte, para o Conselho Superior de Esportes.Este grupo de trabalho se reúne periodicamente; Em sua última reunião, realizada em Barcelona de 3 e 4 de outubro de 2022, foi acordada uma série deconclusões em relação à morte súbita e arritmias no esporte, SARS Cov-2, prevenção, saúde mental, diversidade sexual e especialidade MIR.(AU)

Bloqueo del plano transverso abdominal para control del dolor intra y posoperatorio en herniorrafia inguinal en paciente con síndrome de Brugada / Block of transverse abdominal pain for intra-and posoperative pain control in inguinal herniorrhaphy in patient with Brugada syndrome

Los pacientes con síndrome de Brugada suponen un reto desde el punto de vista anestésico ya que son muchas las circunstancias perioperatorias y los fármacos que pueden desencadenar una crisis arritmogénica, los cuales pueden llegar a tener un fatal desenlace. Las implicaciones anestésicas en estos pacientes son múltiples por lo que se debe ser muy cuidadoso y tener en cuenta muchos factores. Se exponen las consideraciones y el manejo anestésico que se realizó en un paciente con síndrome de Brugada sometido a una herniorrafía inguinal izquierda en la que se opta por la realización de una anestesia general junto con un bloqueo ecoguiado del plano transverso abdominal para control de dolor(AU)

Patients with Brugada syndrome are a challenge from the anesthetic point of view, since there are many perioperative circumstances and drugs that can trigger an arrhythmogenic crisis, which can have a fatal outcome. Anesthetic implications in these patients are multiple, a reason why one must be very careful and take into account many factors. The considerations and anesthetic management are described for the case of a patient with Brugada syndrome who underwent left inguinal herniorrhaphy, in which general anesthesia was chosen together with ultrasound-guided block of transverse abdominal plane for pain control(AU)

Genetic markers for preeclampsia in Peruvian women.

BACKGROUND: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbi-mortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. OBJECTIVE: To determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6) -174 G/C, IL-1ß-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women. METHODS: Were included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared. RESULTS: No association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the -174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the -511 C/T polymorphism of the IL-1ß gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls. CONCLUSION: No association was found between the studied genetic markers and preeclampsia. However, in the -174G/C polymorphism of the IL-6 gene, significant differences were found mainly in the GG genotype and G allele.

Genetic markers for preeclampsia in Peruvian women / Marcadores genéticos de preeclampsia en mujeres peruanas

Abstract Background: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbi-mortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. Objective: To determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6) -174 G/C, IL-1β-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women. Methods: Were included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared. Results: No association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the -174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the -511 C/T polymorphism of the IL-1β gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls. Conclusion: No association was found between the studied genetic markers and preeclampsia. However, in the -174G/C polymorphism of the IL-6 gene, significant differences were found mainly in the GG genotype and G allele.

Resumen Antecedentes: La preeclampsia es un trastorno multiorgánico asociado con la morbi-mortalidad materna y perinatal. En el Perú, su incidencia es del 10% y causa el 22% de las muertes maternas. Se encontró una asociación entre la preeclampsia y ciertos polimorfismos. Objetivo: Determinar asociación entre los polimorfismos genéticos del factor de crecimiento endotelial vascular (VEGF) +936 C/T y +405 G/C, interleucina-6 (IL-6) -174G/C, IL-1β -511 C/T, Apo A-1 -75 G/A, Apo B-100 2488 C/T (Xbal), y preeclampsia en gestantes peruanas. Métodos: Se incluyeron gestantes preeclámpticas y sanas (controles). Las muestras de sangre fueron procesadas para extracción del ADN, y el análisis se realizó con la técnica PCR-RFLP con protocolos específicos para cada gen y confirmación con secuenciamiento Sanger. Se compararon las frecuencias alélicas y genotípicas en los casos (preeclampsia) y los controles. Resultados: No se halló asociación entre los polimorfismos VEGF+936-C/T y VEGF+405 y la preeclampsia. Las frecuencias de los genotipos GG y el alelo G del polimorfismo -174-G/C en el gen IL6 en preeclámpticas y controles, mostraron diferencias significativas, con frecuencias más altas en los casos. Para el polimorfismo -511-C/T del gen IL-1β, no se encontraron diferencias significativas en las frecuencias de genotipos TT comparados con CT+CC. Los genotipos y alelos de las variantes Apo-A1-75-G/A y Apo-B100 Xbal no mostraron diferencias significativas entre los grupos Conclusión: No se encontró asociación entre los marcadores genéticos estudiados y la preeclampsia. Sin embargo, el polimorfismo -174-G/C en el gen IL6 mostró diferencias significativas principalmente en el genotipo GG y el alelo G.

Evaluation of Hygrothermal Behaviour in Heritage Buildings through Sensors, CFD Modelling and IRT.

Architectural heritage, building materials and interior space are highly susceptible to temperature and relative humidity. A better knowledge of the hygrothermal dynamics inside buildings allows an adequate conservation of heritage. This work compares three non-destructive techniques (NDT), such as temperature and relative humidity sensors, finite element simulations (CFD) and thermographic pictures (IRT). The work has made it possible to carry out an assessment of the risk of condensation over a year and to identify affected periods and areas of the building. Sensors and IRT pictures provide real data to validate CFD simulations, facilitating a global analysis of the building. The results provided reflect a great concordance between the NDTs used.

Progress, challenges and ways forward supporting cancer surveillance in Latin America.

Population-based cancer registries (PBCRs) are the only means to provide reliable incidence and survival data as a basis for policy-making and resource allocations within cancer care. Yet, less than 3% and 10% of the respective populations of Central America and South America are covered by high-quality cancer registries. The Global Initiative for Cancer Registry Development provides support to improve this situation via the International Agency for Research on Cancer Regional Hub for Latin America. In this paper, we summarize activities (advocacy, technical assistance, training and research) over the last 5 years, their impact and current challenges, including the implementation of new PBCR in four countries in the region. Despite the favorable political support to cancer registration in many countries, the sustainability of cancer registration remains vulnerable. Renewed efforts are needed to improve data quality in Latin America while ensuring maximum visibility of the data collected by disseminating and promoting their use in cancer control.

A bibliometric study of Revista Española de Enfermedades Digestivas (REED) based on SciELO indicators for the period 2004-2018.

The aim of this study was to show the potentialities offered by the SciELO network indicators for the management of scientific journals, via a case study involving the Revista Española de Enfermedades Digestivas (REED). SciELO offers indicators (production, collaboration, use) that complement the conventional analysis indices used for written science. In order to illustrate their use as a bibliometric, a descriptive study was performed of the scientific production published by the above-mentioned journals during the period 2004-2018. In the last five years, REED received 3,976,685 visits. The second issue from 2007 was the most widely accessed sample to date. A total of 173 issues, 1,810 citable articles, 2,927 documents and 47,645 references have been published, with the number of published papers increasing by 268 %. Clinical case reports make up the highest number. REED received a total of 3,613 citations, with a self-citation rate of 60 %. Of all published documents, 42 % originated in Spain and 10.6 % abroad. Group authorship predominates over individual authors, with a median and mode of 5. The cooperation index was 5.12. The highest impact factor was 0.492 in 2008. The journals most commonly cited by REED are all foreign publications in the Gastroenterology and Hepatology section of the Science Citation Index.

La Seguridad Social llegó al campo: resistencias y limitaciones en la España del segundo franquismo (1959-1975) / A Segurança Social chegou ao campo: resistências e limitações na Espanha do segundo franquismo / Social Security arrives in the country: resistance and limitations in Spain during the late Franco regime (1959-1975)

El objetivo del artículo es analizar dos aspectos de la asistencia sanitaria en el medio rural español durante el segundo periodo de la dictadura franquista (1959-1975). Primero analizamos la implantación del Régimen Especial Agrario de la Seguridad Social (1966), que proporcionó asistencia sanitaria a los trabajadores del campo. Hasta entonces, habían sido excluidos del Seguro Obligatorio de Enfermedad (1944), destinado a obreros industriales y otros asalariados con bajos ingresos. En segundo lugar, analizamos la oposición de los médicos rurales a la ampliación de la cobertura sanitaria a los trabajadores agrícolas. Para lograr ambos objetivos analizamos las limitaciones del ejercicio médico en el ámbito rural y cómo la Dictadura intentó solucionar infructuosamente estos problemas. Las fuentes empleadas han sido: disposiciones legislativas, publicaciones de los colegios profesionales oficiales, prensa dedicada a discutir problemas del ejercicio médico, informes sociológicos y documentación de archivo. (AU)

O objetivo do artigo é analisar dois aspectos da atenção à saúde na Espanha rural durante o segundo período da ditadura de Franco (1959-1975). Em primeiro lugar, analisamos a introdução do Regime Especial de Previdência Social Agrária (1966), que proporcionou assistência médica aos trabalhadores rurais. Até então, eram excluídos do Seguro Obrigatório de Saúde (1944), destinado aos operários da indústria e demais trabalhadores com baixos salários. Em segundo lugar, analisamos a oposição dos médicos rurais à extensão da cobertura de saúde aos trabalhadores agrícolas. Para alcançar ambos os objetivos, analisamos as limitações da prática médica no meio rural e como a ditadura tentou resolver esses problemas, sem sucesso. As fontes utilizadas são: disposições legislativas, publicações de associações profissionais oficiais, imprensa dedicada a discutir problemas da prática médica, relatórios sociológicos e documentação arquivística. (AU)

The objective of the article is to analyze two aspects of healthcare in rural Spain during the second period of the Franco dictatorship (1959-1975). Firstly, we analyze the introduction of the Special Agrarian Social Security Regime (1966), which provided healthcare to rural workers. Until then, rural workers had been excluded from the Compulsory Health Insurance (1944), which provided healthcare to industrial and other low-income workers. Secondly, we analyze the position of rural doctors against the extension of health coverage to rural workers. To achieve both objectives, we analyze the limitations of medical practice in the rural milieu and how Franco's dictatorship unsuccessfully managed these limitations. We have used several sources: legal regulations, publications of official professional associations, press devoted to medical practice, sociological reports, and archival records. (AU)

[Medical education and medical anthropology in Europe: the cases of Italy and Spain]. / Educación sanitaria y antropología médica en Europa: los casos de Italia y España.

The aim of this article is to compare the development of health education in Italy and Spain from the point of view of the role played by medical anthropology in both countries. The context is provided by the changes in the concept of health education advocated by the UN technical agencies, especially the World Health Organization and Unesco, during the second half of the twentieth century. Despite their many similarities, Italy and Spain underwent different political evolutions over the last century. Therefore, it is interesting to compare both cases and the influence the social sciences had in health education initiatives. In order to assess the role of medical anthropology, the 1958 launch and the development of the Centro Sperimentale per l'Educazione Sanitaria (Perugia, Italy), which was at the forefront of health education in Europe until the 1990s, was reconstructed through oral sources. After a brief description of the scant initiatives regarding health education existing in the Spain of the dictatorship, the influence of the Perusine anthropologists on Spanish health education during the democratic transition is evaluated.

Educación sanitaria y antropología médica en Europa: los casos de Italia y España / Medical education and medical anthropology in Europe: the cases of Italy and Spain

RESUMEN El objetivo de este artículo es comparar el desarrollo de la educación sanitaria en Italia y España desde el punto de vista del papel jugado por la antropología médica en ambos países, en un contexto marcado por los cambios en el concepto de educación sanitaria que propugnaron los organismos técnicos de las Naciones Unidas, en especial la Organización Mundial de la Salud y la Unesco, durante la segunda mitad del siglo XX. A pesar de sus similitudes como países, Italia y España tuvieron evoluciones políticas muy diferentes durante el siglo pasado, por tanto, es interesante comparar ambos casos y la influencia que tuvieron las ciencias sociales en las iniciativas de educación sanitaria. Para valorar el papel de la antropología médica, mediante el uso de fuentes orales, hemos reconstruido la puesta en marcha, en 1958, y el desarrollo del Centro Sperimentale per l'Educazione Sanitaria (Perugia, Italia), que estuvo en la vanguardia de la educación sanitaria en Europa hasta los años noventa. Tras una breve descripción de las escasas iniciativas sobre educación sanitaria en la España de la dictadura, evaluamos la influencia de los antropólogos perusinos en la educación para la salud española durante la transición democrática.

ABSTRACT The aim of this article is to compare the development of health education in Italy and Spain from the point of view of the role played by medical anthropology in both countries. The context is provided by the changes in the concept of health education advocated by the UN technical agencies, especially the World Health Organization and Unesco, during the second half of the twentieth century. Despite their many similarities, Italy and Spain underwent different political evolutions over the last century. Therefore, it is interesting to compare both cases and the influence the social sciences had in health education initiatives. In order to assess the role of medical anthropology, the 1958 launch and the development of the Centro Sperimentale per l'Educazione Sanitaria (Perugia, Italy), which was at the forefront of health education in Europe until the 1990s, was reconstructed through oral sources. After a brief description of the scant initiatives regarding health education existing in the Spain of the dictatorship, the influence of the Perusine anthropologists on Spanish health education during the democratic transition is evaluated.

Factor structure and psychometric properties of the Spanish version of the "Dysfunctional Attitude Scale-Revised" / Estructura factorial y propiedades psicométricas de la versión en español de la "Escala de actitudes disfuncionales-revisada"

The Dysfunctional Attitude Scale (DAS) is a 40-item measure of dysfunctional schemas, a key construct of the cognitive model of depression. Most research has relied on the total score because of the mixed results of previous exploratory factor analyses conducted on the DAS. Accordingly, a revised, 17-item version of the DAS (hereafter, the DAS-R) has been recently proposed using confirmatory factor analysis (CFA) and containing two factors: Perfectionism/Performance evaluation and Dependency. This study analyzes the factor structure and psychometric properties of the Spanish version of the DAS-R with a total of 629 participants. The DAS-R showed good internal consistency, temporal stability, and discriminant and convergent validity. CFA supported the two-factor solution found in the original scale; however, a hierarchical factor model with two first-order factors and a general factor showed the best fit of the data. The DAS-R provides general and specific measures of dysfunctional schemas that are theoretically meaningful

La "Escala de actitudes disfuncionales" (DAS) es una medida de 40 items de los esquemas disfuncionales, un constructo clave del modelo cognitivo de la depresion. La mayor parte de la investigacion ha utilizado la puntuacion total debido a los resultados mixtos de los analisis factoriales exploratorios realizados sobre el DAS. De acuerdo a esto, una version reducida del DAS con 17 items (DAS-R) ha sido propuesta recientemente usando analisis factorial confirmatorio (AFC) y consistente en dos factores: Perfeccionismo/Evaluacion del rendimiento y Dependencia. Este estudio analiza la estructura factorial y las propiedades psicometricas de la version espanola de la DAS-R con un total de 629 participantes. La DAS-R mostro una buena consistencia interna, estabilidad temporal y validez discriminante y convergente. El AFC apoyo el modelo bifactorial encontrado en la escala original; sin embargo, un modelo factorial jerarquico con dos factores de primer orden y un factor general mostro el mejor ajuste a los datos. La DAS-R provee medidas generales y especificas de los esquemas disfuncionales que son teoricamente significativas

The effect of relational training on intelligence quotient: a case study / El efecto del entrenamiento en comportamiento relacional sobre el cociente de inteligencia: un estudio de caso

BACKGROUND: Relational training protocols based on Relational Frame Theory (RFT) are showing promising results in increasing intelligence quotient. This case study aimed at analyzing the effect of a training protocol in fluency and flexibility in relational responding on intelligence quotient with a 4-year-old child. METHOD: The child's cognitive and psychomotor development was evaluated before and after the implementation of the training protocol using the McCarthy's Aptitudes and Psychomotricity Scale (MSCA). The training protocol consisted of a multiple-exemplar-training (MET) in relational framing in accordance with COORDINATION (Phases 1 and 2), OPPOSITION (Phase 3 and 4), and COMPARISON (Phases 5 and 6). The MET protocol was implemented in approximately 12 hours throughout five and one half months. RESULTS: The training was effective in establishing relational responding in OPPOSITION and COMPARISON frames as well as in promoting fluency and flexibility in all the three types of trained relations. After this training, the child showed an increase above 1.5 SD in the General Cognitive Index of the MSCA (from 106 to 131). CONCLUSIONS: This case study adds further empirical evidence of the potential of RFT training to improve cognitive abilities and intelligence

ANTECEDENTES: los protocolos de entrenamiento relacional basados en la Teoría del Marco Relacional (TMR) están mostrando resultados prometedores en el incremento del cociente de inteligencia. El objetivo de este estudio de caso fue analizar el efecto de un entrenamiento en fluidez y flexibilidad en comportamiento relacional sobre el cociente de inteligencia en un niño de 4 años. MÉTODO: se evaluó el desarrollo cognitivo y psicomotor del niño a través de las Escalas de Aptitudes y Psicomotricidad de McCarthy (MSCA). La intervención consistió en un entrenamiento relacional en múltiples ejemplos para enmarcar en COORDINACIÓN (Fases 1 y 2), OPOSICIÓN (Fases 3 y 4) y COMPARACIÓN (Fases 5 y 6). El entrenamiento se aplicó en 12 horas aproximadamente durante cinco meses y medio, y resultó eficaz en generar comportamiento relacional para enmarcar en OPOSICIÓN y COMPARACIÓN y en promover fluidez y flexibilidad en los tres marcos relacionales. RESULTADOS: el niño mostró un incremento superior a 1.5 DT en el Índice Cognitivo General del MSCA (de 106 a 131). CONCLUSIONES: este estudio añade evidencia al potencial de los entrenamientos basados en la TMR para mejorar las habilidades cognitivas e inteligencia

A further Experimental Step in the Analysis of Hierarchical Responding

This study is a step forward in the difficult task of analyzing the transformation of functions via hierarchical relations. Eight participants underwent a computer task with five phases. During Phase 1, four stimuli were trained to become the following relational cues: INCLUDES, BELONGS TO, SAME, and DIFFERENT. In Phase 2, three equivalence classes were trained and tested (A1-B1-C1-D1; A2-B2-C2-D2; A3-B3-C3-D3). During Phase 3, inclusion relations were first established, by using the INCLUDES and BELONGS TO relational cues, between the to-be lower levels of the hierarchy, namely A1/B1, A2/B2, and A3/B3; and stimuli X.1, X.2, and Y.1, respectively. Then, the INCLUDES relational cue was used to establish inclusion relations between X.1/X.2 and X, and between Y.1 and Y, so that X and Y would become the most inclusive levels of two separate hierarchical networks. In Phase 4, X.1 was established as cold, D2 as heavy, and C3 as sweet. Lastly, in Phase 5 (Critical Test), seven stimuli from both hierarchical networks were tested for the transformation of functions. Five of the six participants who made it to this test responded correctly. Implications, limitations, and further research are discussed (AU)

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Ambulatory estimation of human circadian phase using models of varying complexity based on non-invasive signal modalities.

In this work, we introduce a number of models for human circadian phase estimation in ambulatory conditions using various sensor modalities. Machine learning techniques have been applied to ambulatory recordings of wrist actigraphy, light exposure, electrocardiograms (ECG), and distal and proximal skin temperature to develop ARMAX models capturing the main signal dependencies on circadian phase and evaluating them versus melatonin onset times. The most accurate models extracted heart rate variability features from an ECG coupled with wrist activity information to produce phase estimations with prediction errors of ~30 minutes. Replacing the ECG features with skin temperature from the upper leg led to a slight degradation, while less accurate results, in the order of 1 hour, were obtained from wrist activity and light measurements. The trade-off between highest precision and least obtrusive configuration is discussed for applications to sleep and mood disorders caused by a misalignment of the internal phase with the external solar and social times.

Human circadian phase estimation from signals collected in ambulatory conditions using an autoregressive model.

Phase estimation of the human circadian rhythm is a topic that has been explored using various modeling approaches. The current models range from physiological to mathematical, all attempting to estimate the circadian phase from different physiological or behavioral signals. Here, we have focused on estimation of the circadian phase from unobtrusively collected signals in ambulatory conditions using a statistically trained autoregressive moving average with exogenous inputs (ARMAX) model. Special attention has been given to the evaluation of heart rate interbeat intervals (RR intervals) as a potential circadian phase predictor. Prediction models were trained using all possible combinations of RR intervals, activity levels, and light exposures, each collected over a period of 24 hours. The signals were measured without any behavioral constraints, aside from the collection of saliva in the evening to determine melatonin concentration, which was measured in dim-light conditions. The model was trained and evaluated using 2 completely independent datasets, with 11 and 19 participants, respectively. The output was compared to the gold standard of circadian phase: dim-light melatonin onset (DLMO). The most accurate model that we found made use of RR intervals and light and was able to yield phase estimates with a prediction error of 2 ± 39 minutes (mean ± SD) from the DLMO reference value.

Vector control intervention towards interruption of transmission of Chagas disease by Rhodnius prolixus, main vector in Guatemala.

In Guatemala, the Ministry of Health (MoH) began a vector control project with Japanese cooperation in 2000 to reduce the risk of Chagas disease infection. Rhodnius prolixus is one of the principal vectors and is targeted for elimination. The control method consisted of extensive residual insecticide spraying campaigns, followed by community-based surveillance with selective respraying. Interventions in nine endemic departments identified 317 villages with R. prolixus of 4,417 villages surveyed. Two cycles of residual insecticide spraying covered over 98% of the houses in the identified villages. Fourteen villages reinfestated were all resprayed. Between 2000-2003 and 2008, the number of infested villages decreased from 317 to two and the house infestation rate reduced from 0.86% to 0.0036%. Seroprevalence rates in 2004-2005, when compared with an earlier study in 1998, showed a significant decline from 5.3% to 1.3% among schoolchildren in endemic areas. The total operational cost was US$ 921,815, where the cost ratio between preparatory, attack and surveillance phases was approximately 2:12:1. In 2008, Guatemala was certified for interruption of Chagas disease transmission by R. prolixus. What facilitated the process was existing knowledge in vector control and notable commitment by the MoH, as well as political, managerial and technical support by external stakeholders.