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Curr Cardiol Rev ; 7(3): 163-83, 2011 Aug.
Article in English | MEDLINE | ID: mdl-22758615

ABSTRACT

Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both ventricles can dilate and diminish its ejection fraction, having less response to fluid resuscitation and catecholamines, but typically is assumed to be reversible within 7-10 days. In the last 30 years, It's being subject of substantial research; however no explanation of its etiopathogenesis or effective treatment have been proved yet. The aim of this manuscript is to review on the most relevant aspects of the sepsis-induced myocardial dysfunction, discuss its clinical presentation, pathophysiology, etiopathogenesis, diagnostic tools and therapeutic strategies proposed in recent years.


Subject(s)
Cardiomyopathies/diagnosis , Cardiomyopathies/etiology , Sepsis/complications , Animals , Calcium/metabolism , Cardiomyopathies/therapy , Humans , Microcirculation/physiology , Myocardial Ischemia/etiology , Myocardium/metabolism , Myofibrils/metabolism , Receptors, Adrenergic, beta/metabolism , Sepsis/physiopathology , Toll-Like Receptors/metabolism , Ventricular Dysfunction, Left/diagnosis , Ventricular Dysfunction, Left/etiology , Ventricular Dysfunction, Left/therapy , Ventricular Dysfunction, Right/diagnosis , Ventricular Dysfunction, Right/etiology , Ventricular Dysfunction, Right/therapy
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