ABSTRACT
Real-time sonography is a well-accepted technique for evaluating abnormalities of the eye. Most previous reports on sonography of the eye have been in adults [1]. In this pictorial essay, we illustrate normal and abnormal findings of ocular sonography in children.
Subject(s)
Eye/diagnostic imaging , Adolescent , Child , Child, Preschool , Eye Diseases/diagnostic imaging , Eye Infections/diagnostic imaging , Eye Injuries/diagnostic imaging , Eye Neoplasms/diagnostic imaging , Female , Humans , Infant , Male , UltrasonographyABSTRACT
We describe congenital colobomatous malformations of the optic nerve and the clinical variations and complications that may appear eventually in them. We also present two clinical cases of patients with papillary colobomatous defects where spontaneous variations have been observed throughout their evolution and where the current ophthalmoscopic aspect is completely different from the initial one. Finally, bearing in mind the embryologic origin and histologic structure of these anomalies, we develop a hypothesis that explains the physiopathologic mechanism that causes the clinical changes described in each case.
Subject(s)
Coloboma/pathology , Ophthalmoscopy/methods , Optic Nerve/abnormalities , Coloboma/complications , Female , Fundus Oculi , Humans , Infant , Male , Optic Disk/abnormalities , Optic Disk/pathology , Optic Nerve/pathology , Retinal Diseases/etiology , Retinal Diseases/pathology , Tomography, X-Ray ComputedABSTRACT
Two cases of cytomegalovirus retinitis in pediatric acquired immunodeficiency syndrome (AIDS) are described. The first case was a 7-month-old infant who received an HIV-infected blood transfusion in 1983. The infant was treated with specific anti-cytomegalovirus immunoglobulin. The second case was an 8-year-old hemophiliac child who received HIV-infected factor VIII concentrates. Intravenous ganciclovir therapy resulted in marked improvement of ocular lesions. This is, to our best knowledge, the first report of pediatric AIDS-induced retinopathy resulting from postnatal intravenous causes.
Subject(s)
AIDS-Related Opportunistic Infections , Cytomegalovirus Infections/etiology , Eye Infections, Viral/etiology , Retinitis/microbiology , AIDS-Related Opportunistic Infections/complications , Acquired Immunodeficiency Syndrome/etiology , Child , Factor VIII/adverse effects , Ganciclovir/therapeutic use , Humans , Infant , Male , Transfusion ReactionABSTRACT
Aplasia of the optic nerve is a very rare congenital anomaly characterized by an absence of optic nerve fibers, retinal ganglion cells, and the retinal central blood vessels. It may be associated with a wide range of other congenital abnormalities. In the present article, three cases of aplasia of the optic nerve are described. Its pathology and clinical features are reviewed.
Subject(s)
Eye Abnormalities/pathology , Optic Nerve/abnormalities , Eye Abnormalities/diagnostic imaging , Female , Fluorescein Angiography , Fundus Oculi , Humans , Infant , Male , Optic Nerve/diagnostic imaging , Optic Nerve/pathology , Retinal Diseases/pathology , Retinal Vessels/abnormalities , Tomography, X-Ray ComputedABSTRACT
The total fatty acid composition of the human retina was studied during early normal development and compared to that found in infancy and in adulthood. The retina of an infant undernourished prenatally and of two malnourished postnatally were also studied and compared to the normal values for the age. The fatty acid patterns of ethanolamine phosphoglycerides (EPG) and choline phosphoglycerides (CPG) were also studied. Total and ethanolamine plasmalogens (EP) were estimated by the aldehyde dimethyl acetal (DMA) content of total lipids and of EPG, respectively. After acid methanolysis, analyses of fatty acid methyl esters (FAME) and of DMA were effected by capillary GLC on a single 30 m long, SP-2330, capillary column. The main developmental fatty acid changes were an increase in 22:6 omega 3, 22:5 omega 3 and 20:3 omega 6 and a decrease in 20:4 omega 6. The 22:6 omega 3/20:4 omega 6 ratio increased in a very significant, parabolical way throughout development. In contrast to the brain, the proportion of ethanolamine plasmalogens decreased with maturation, whereas the ratio 18DMA/16DMA increased. The two postnatally malnourished infants had a very significant increase in retinal 22:5 omega 6, but only the child that had been fed on a very unbalanced omega 3/omega 6 diet since 25 weeks of gestation showed an important decrease in retinal 22:6 omega 3.
