Myotendinopathy of Unknown Etiology in Broiler Breeder Males.

This case series describes an emerging and ongoing lameness condition observed in broiler breeder males in flocks owned by a broiler integrator in the United States between February 2021 and April 2023. The lameness is characterized by an upright, penguin-like posture and gait. Affected flocks are typically 12-22 wk of age at presentation, but birds with similar stance and gross lesions can be observed as early as 1 day of age. Male mortality associated with this condition ranges from 0.01% to 6% per flock. The condition is infrequently observed in pullets from the female line but has not been observed in males (sex slips) from the female line. On postmortem examination, affected birds have bilateral hemorrhage due to a tearing of the iliotibialis muscles and fascia. In one case, a higher proportion of affected birds had unilateral lesions concurrently with broken legs or severe inguinal vaccine reaction. In this case, the affected leg was the weight-bearing leg. Histopathology confirmed the presence of hemorrhage in fascial sheaths surrounding major muscles, in addition to muscle fiber necrosis, edema, fibroplasia, and dissociation of tendon collagen. Bacteriology, histopathology, and clinical presentation identified no factors that were suggestive of an infectious etiology for this condition. No etiology has been established, but a suggested pathogenesis involves excessive biomechanical force resulting in tendon structural stress, leading to separation of tendon collagen fibers and associated muscle fiber stretching, separation, necrosis, and hemorrhage. The condition has been reported in multiple genetic lines, but the role of inheritance in the condition has not been fully evaluated.

Miotendinopatía de etiología desconocida en machos reproductores pesados. Esta serie de casos describe una condición de cojera emergente y recurrente observada en parvadas de machos reproductores pesados propiedad de un integrador de pollo de engorde en los Estados Unidos entre febrero del 2021 y abril del 2023. La cojera se caracteriza por una postura y desplazamientos corporales en forma erguida, parecidos a los de los pingüinos. Las parvadas afectadas suelen tener entre 12 y 22 semanas de edad en el momento de la presentación, pero se han podido observar aves con similar postura corporal y lesiones macroscópicas tan temprano como al primer día de edad. La mortalidad de los machos asociada con esta condición oscila entre el 0.01% y el 6% por parvada. La condición se observa con poca frecuencia en pollitas de la línea hembra, pero no se ha observado en machos provenientes de la misma línea hembra (errores de sexado). En el examen post mortem, las aves afectadas presentan hemorragia bilateral debido a un desgarramiento de los músculos iliotibiales y la fascia. En un caso, una mayor proporción de aves afectadas tuvieron lesiones unilaterales simultáneamente con patas rotas o una reacción postvacunal severa en la región inguinal. En este caso, la pierna afectada era la misma que soportaba peso. La histopatología confirmó la presencia de hemorragia en las vainas fasciales que rodean los músculos principales, además de necrosis de fibras musculares, edema, fibroplasia y disociación del colágeno del tendón. Mediante la bacteriología, la histopatología y la presentación clínica no se identificaron factores que sugirieran una etiología infecciosa para esta afección. No se ha establecido una etiología, pero una patogénesis sugerida implica una fuerza biomecánica excesiva que produce estrés estructural del tendón, lo que lleva a la separación de las fibras de colágeno del tendón y al estiramiento, separación, necrosis y hemorragia de las fibras musculares asociadas. La afección se ha informado en múltiples líneas genéticas, pero no se ha evaluado completamente el papel de la genética en esta condición.

Testicular Atrophy and Epididymitis-Orchitis Associated with Infectious Bronchitis Virus in Broiler Breeder Roosters.

Infectious bronchitis is a respiratory disease of chickens caused by a gammacoronavirus named infectious bronchitis virus (IBV). In addition to affecting the respiratory tract, IBV may also induce urogenital infections, leading to nephropathogenic disease, false layer syndrome in laying hens, and epididymal lithiasis and epididymitis in males. Here, we report a case of decreased reproductive efficiency due to male infertility in 33- to 38-wk-old broiler breeders. At necropsy, the males presented with urates deposited on the skin around the vent and testicular asymmetry due to marked unilateral atrophy. Histopathology revealed lymphocytic epididymitis, epididymal lithiasis, and orchitis. IBV antigen was detected within collecting and efferent ducts of epididymides by immunohistochemistry. IBV strain DMV/1639 was detected by reverse transcription-quantitative PCR in pools of testes, oviducts, tracheas, cecal tonsils, and kidneys from a 37-wk-old affected flock. This report shows evidence of the role of IBV in male chicken infertility and highlights the importance of performing molecular surveillance of IBV to monitor vaccine strains and to detect emerging variants that can potentially hinder production.

Reporte de caso- Atrofia testicular y epididimitis-orquitis asociadas con el virus de la bronquitis infecciosa en gallos reproductores pesados. La bronquitis infecciosa es una enfermedad respiratoria del pollo causada por un gammacoronavirus llamado virus de la bronquitis infecciosa (con las siglas en inglés IBV). Además de afectar el tracto respiratorio, el IBV también puede inducir infecciones urogenitales, lo que conduce a enfermedad nefropatogénica, síndrome de la falsa ponedora en gallinas de postura y litiasis epididimaria y epididimitis en machos. En este reporte se describe un caso de disminución de la eficiencia reproductiva debido a la infertilidad de machos en reproductores pesados de 33 a 38 semanas de edad. En la necropsia, los machos presentaron depósitos de uratos sobre la piel alrededor de la cloaca y asimetría testicular por atrofia unilateral marcada. La histopatología reveló epididimitis linfocítica, litiasis epididimaria y orquitis. Antígenos del virus de la bronquitis infecciosa se detectaron dentro de los conductos colectores y eferentes de los epidídimos mediante inmunohistoquímica. La cepa del virus de la bronquitis DMV/1639 se detectó mediante transcripción reversa y PCR cuantitativa en muestras agrupadas de testículos, oviductos, tráqueas, tonsilas cecales y riñones de una parvada afectada de 37 semanas de edad. Este reporte muestra evidencia del papel del virus de la bronquitis infecciosa en la infertilidad de los pollos machos y destaca la importancia de realizar una vigilancia molecular de este virus para monitorear las cepas vacunales y detectar variantes emergentes que potencialmente pueden dificultar la producción.

Anterior meniscopexy: a meniscal sparing technique for the treatment of locking but intact discoid lateral meniscus.

PURPOSE: Symptomatic discoid lateral meniscus without tears has traditionally been treated with excision of part or the entire meniscus. Resection of 15-34% of the meniscus increases tibiofemoral contact pressures by more than 350%. Treatment of discoid lateral meniscus with partial or total meniscectomy in childhood increases the risk of early-onset osteoarthritis in the knee. The incidence of osteoarthritis is directly proportional to the amount of meniscal tissue resected. This paper describes the meniscus-preserving technique of meniscopexy and presents the outcomes of all patients who have undergone this procedure in the management of lateral discoid meniscus in a single unit over a 14-year period. METHODS: A retrospective study was carried out reviewing all patients who underwent meniscopexy for the treatment of MRI-confirmed discoid lateral meniscus without meniscal tear between 2001 and 2015 with a minimum of 1-year follow-up. Eleven patients (12 knees) were identified using a patient database of all patients that had undergone this procedure in our institution. Two patients were excluded from the final results, so nine patients (10 knees) were scored post-operatively at last follow-up using the Lysholm knee score. We reviewed all available post-operative MRI scans and recorded any complications. RESULTS: Four patients were male and seven were female. The median age of the patients at the time of surgery was 9 (6-14), and the median follow-up was 4.5 years (2-14). The median Lysholm knee score was 91 (86-100). The outcome for all patients scored was either good or excellent. CONCLUSION: The established treatment options for symptomatic discoid lateral meniscus without associated tear involve resection of meniscal tissue. Using this technique, all the meniscal tissue is preserved, thus reducing the risk of arthritic change in the future. MRI studies performed post-operatively suggested normalisation of meniscal morphology with time. Meniscopexy offers an effective alternative to the established treatment options in the management of symptomatic discoid lateral meniscus without meniscal tears. LEVEL OF EVIDENCE: IV.

Validation of a novel smartphone accelerometer-based knee goniometer.

Loss of full knee extension following anterior cruciate ligament surgery has been shown to impair knee function. However, there can be significant difficulties in accurately and reproducibly measuring a fixed flexion of the knee. We studied the interobserver and the intraobserver reliabilities of a novel, smartphone accelerometer-based, knee goniometer and compared it with a long-armed conventional goniometer for the assessment of fixed flexion knee deformity. Five healthy male volunteers (age range 30 to 40 years) were studied. Measurements of knee flexion angle were made with a telescopic-armed goniometer (Lafayette Instrument, Lafayette, IN) and compared with measurements using the smartphone (iPhone 3GS, Apple Inc., Cupertino, CA) knee goniometer using a novel trigonometric technique based on tibial inclination. Bland-Altman analysis of validity and reliability including statistical analysis of correlation by Pearson's method was undertaken. The iPhone goniometer had an interobserver correlation (r) of 0.994 compared with 0.952 for the Lafayette. The intraobserver correlation was r = 0.982 for the iPhone (compared with 0.927). The datasets from the two instruments correlate closely (r = 0.947) are proportional and have mean difference of only -0.4 degrees (SD 3.86 degrees). The Lafayette goniometer had an intraobserver reliability +/- 9.6 degrees. The interobserver reliability was +/- 8.4 degrees. By comparison the iPhone had an interobserver reliability +/- 2.7 degrees and an intraobserver reliability +/- 4.6 degrees. We found the iPhone goniometer to be a reliable tool for the measurement of subtle knee flexion in the clinic setting.

Function and survival after revision of hip resurfacing.

The purpose of this study was to compare functional outcome and survival of isolated acetabular, isolated femoral and both component revision after failure of primary Birmingham Hip Resurfacing. The Oswestry Outcome Centre prospectively collected data on 5000 hip resurfacing between 1997 and 2002. Of these, 182 hips were revised: 8% had revision of the acetabular component only, 42% had revision of the femoral component only to conventional stemmed prosthesis, and 50% had revision of both components to conventional total hip arthroplasty (THA). We used a postal questionnaire to assess function by Harris and Merle d'Aubigné and Postel hip scores and determined survival using re-revision as an endpoint. In patients with isolated acetabular revision, the median Harris hip score (HHS) was 74 at a mean of 4.5 years follow up. Isolated femoral revision had a median HHS of 82 at a mean of 3.8 years. When both components were revised, the median HHS was 85 at a mean of 4 years. We observed no difference in HHS between the groups. There was an average survival of 92% at 10 years. Survival was significantly lower for isolated acetabular revision (75%) than isolated femoral (93%) or both component revision (96%).

Birmingham hip resurfacing in patients who are seventy years of age or older.

There is no published literature to support mid to long term results of hip resurfacing (HR) arthroplasty in patients over the age of 70 years. The purpose of our study was to evaluate the function HR in this age group (70 or older at the time of surgery) at medium to long term follow-up. Between July 1997 and November 2002, the Oswestry Outcome Centre independently and prospectively collected data on 5000 Birmingham Hip Resurfacings (BHRs). 106 had been implanted in elderly patients who were 70 years of age or older. The post-operative Harris and Merle D'Aubigné and Postel (MDP) hip scores and causes for revision were used to ascertain function and implant survival. Hip scores for the older BHR patients were compared with those from younger patients. The average age at surgery of the elderly BHR cohort was 73.2 years (range, 70.0 to 87.9 years) with a mean follow-up of 7.1 years (range, 0.5 to 10.9 years). Four patients had a femoral neck fracture and required conversion to a conventional total hip replacement. There were no patients lost to follow-up and no dislocations in this series. The median Harris hip score (HHS) was significantly better in the younger BHR group compared with the elderly BHR group, (96 vs. 94 p=0.008). There was no significant difference in recovery rates after surgery. There was a significantly higher rate of revision in women than men among the elderly patients (male= 1 of 65 (1.5%); women = 3 of 19 (15.8%), p=0.03). At latest follow-up the elderly patients continued to function well when compared with the younger BHR patients. There was a high mid to long term success rate after HR in patients who were 70 years of age or older, without the failure burden possibly anticipated. Elderly patients had a poorer functional outcome, but a difference in HHS of two points may be of only minor clinical significance.