Integrating 3Rs approaches in WHO guidelines for the batch release testing of biologicals: Responses from a survey of National Control Laboratories and National Regulatory Authorities.

The UK National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) is reviewing World Health Organization (WHO) manuals, guidelines and recommendations for vaccines and biotherapeutics to identify the extent to which animal-based testing methods are described. The aim is to recommend where updates to these documents can lead to an increased and more harmonised adoption of 3Rs principles (i.e. Replacement, Reduction and Refinement of animal tests) in the quality control and batch release testing requirements for vaccines and biotherapeutics. Improved adoption of 3Rs principles and non-animal testing strategies will help to reduce the delays and costs associated with product release testing. Developing recommendations that are widely applicable by both the manufacturers and national regulatory authorities for vaccines and biological therapeutics globally requires a detailed understanding of how different organisations view the opportunities and barriers to better integration of the 3Rs. To facilitate this, we developed and distributed a survey aimed at individuals who work for national regulatory authorities (NRAs) and/or national control laboratories (NCLs). In this paper, we present the key findings from this survey and how these will help inform the recommendations for wider integration of 3Rs approaches by WHO in their guidance documents applicable to the quality control and batch release testing of vaccines and biotherapeutics.

A method for increasing 3D body scanning's precision: Gryphon and consecutive scanning.

The fashion industry cannot use 3 D Body Scanning to create custom garment patterns because its measurements fail to meet ISO 20685:2010's tolerances. To advance 3 D Body Scanning's precision, we present Gryphon: an algorithm that removes the two most extreme measurements from five body scans; removing potentially erroneous data. We assess Gryphon's precision against current industry practice, determine if consecutive and non-consecutive data capture influences precision, and determine 3 D Body Scanning's inherent imprecision inherent. We analyse 97 participants over 121 industry-standard measurements for consecutive and non-consecutive data-capture through MANOVA statistical analysis. Under current industry practice, only one measurement meets ISO 20685. However, under Gryphon and consecutive scanning, 97.5% of measurements meet ISO 20685. We also prove that the body's in-scan movement does not affect reliability. Ultimately, we offer the fashion industry, ergonomists, and practitioners an accessible method to increase 3 D Body Scanning's precision at a level unavailable under previous methods. Practitioner Summary: Ergonomists need precise data, yet we prove 0% of 3 D Body Scanning's measurements meet ISO 20685's tolerances. Our analysis of 97 participants scans, shows consecutive scanning is necessary to achieve data suitable for anthropometric applications. We develop the Gryphon process with consecutive scanning, making 97.3% of measurements meet ISO 20685. Abbreviations: ISO: International Organisation for Standards; Three Dimensional: 3D; MANOVA: Multivariate analysis of variance.

Assessing the female figure identification technique's reliability as a body shape classification system.

This paper demonstrates the effects of slight differences in measurement definitions on resultant body shape classification. Ergonomic researchers consider the Female Figure Identification Technique (FFIT) a 'gold standard' body shape classification system to describe variation in a population's 3 D profile. Nevertheless, researchers use FFIT without a scientific basis or considering their ergonomic suitability. This paper rigorously evaluates FFIT, focussing on ergonomics, garment construction, and scientific research applications. Through analysing 1,679 3 D Body Scans, we assess the level of agreement between the FFIT's body shape classification when measurements placed following FFIT's or SizeUK's guidance. We establish how different interpretations of FFIT's measurement placement cause the same body to be categorised into different shapes - in up to 40% of cases. FFIT omits shoulder measurements that have little relationship to body shape yet are vital in garment construction. Using FFIT with different datasets and definitions, therefore, leads to inconsistent conclusions about shape differences.

'I didn't realise I was such a sausage': men's accounts of whole-body scanning, body image, and expected changes in health-related behaviours.

OBJECTIVE: Whole-body scanning is now available in stores to assist buyers in choosing well-fitting clothes. This study was designed to investigate men's accounts of scanning, body image and expectations of behaviour change. DESIGN: Ten men aged 18-39 years without histories of eating disorders or previous experience of whole-body scanning, took part in semi-structured interviews before and after scanning. Data were analysed using inductive thematic analysis. RESULTS: Pre-scan, men's body ideals were tall, slender and relatively muscular. Post-scan, seven reported looking shorter, fatter, thinner and/or less symmetrical than they hoped; three were pleasantly surprised by the images. Men were interested in scans as an objective view of their bodies and as a 'wake-up call' to motivate healthy behaviours. Five men intended to change their behaviour as a result of scanning, and repeat scanning was seen as a good way to monitor behavioural changes. Participants suggested that scanning may raise body concerns in other men, though downplayed impacts on their own body image. CONCLUSION: Whole-body scanning may encourage men to exercise and eat more healthily. However, men became more negative about their bodies as a result of seeing their body scans, so scanning needs to be carried out with supervision and support.

Insights on the apparel needs and limitations for athletes with disabilities: The design of wheelchair rugby sports-wear.

Wheelchair rugby is a sport that has been gaining popularity with athletes with disabilities. However, as it is relatively new and not played by the masses, market specific sports-wear is not available for this sport, which impacts directly on performance and clothing satisfaction of the athletes. Therefore, the main objective of this research was to identify the problems that wheelchair rugby players face with the sports-wear they use for playing the game. The data was collected using a focus group and a questionnaire with 61 wheelchair rugby players in the United Kingdom. Based on their suggestions, on the team expertise, and on the literature, a set of design recommendations was proposed for the upper body garments (tops), lower body garments (bottoms), and gloves. The results demonstrated that the gloves currently available negatively impact on players' ability to participate with satisfactory levels of protection and comfort. Moreover, tops and bottoms also present issues, mainly in the fit and ability to regulate the core body temperature. Hence, the recommendations proposed can provide designers with key information on the specific sports-wear requirements and allow them to design and develop products that can satisfy real needs of specific end-users. This paper intends to raise awareness of the needs of sports-wear for those playing wheelchair rugby and promote the inclusivity of athletes with disabilities.

'I think a little bit of a kick is sometimes what you need': Women's accounts of whole-body scanning and likely impact on health-related behaviours.

OBJECTIVE: This study was designed to investigate whether whole-body scanning might promote healthy eating and physical activity in women, and to explore the effects of scanning on body image. DESIGN: Fourteen women aged 22-45 years without histories of eating disorders or whole-body scanning took part in semi-structured interviews before and after scanning. Data were analysed using inductive thematic analysis. RESULTS: Scans did not look as expected, and participants expressed 'surprise' and 'shock'. Participants focused on perceived negative aspects of their bodies as revealed in scan images, and agreed that women with body concerns would find scans too 'real' and 'raw'. Eleven women who met UK Government physical activity and healthy eating guidelines reported that the scan provided additional motivation to maintain, and in nine cases to increase, those behaviours. Two women who neither exercised nor ate healthily would not increase physical activity or change their diets significantly following scanning. CONCLUSION: Whole-body scanning may enable maintenance or even acceleration of physical activity and healthy eating, but is unlikely to be useful in promoting initiation of these behaviours. Participants engaged in unhelpful body critique when viewing scans; scanning needs to be confined to contexts where support is provided, to avoid increasing body-related concerns.

Scan posture definition and hip girth measurement: the impact on clothing design and body scanning.

Ergonomic measurement is central to product design and development; especially for body worn products and clothing. However, there is a large variation in measurement definitions, complicated by new body scanning technology that captures measurements in a posture different to traditional manual methods. Investigations of hip measurement definitions in current clothing measurement practices supports analysis of the effect of scan posture and hip measurement definition on the circumferences of the hip. Here, the hip girth is a key clothing measurement that is not defined in current body scanning measurement standards. Sixty-four participants were scanned in the standard scan posture of a [TC]2 body scanner, and also in a natural posture similar to that of traditional manual measurement collection. Results indicate that scan posture affects hip girth circumferences, and that some current clothing measurement practices may not define the largest lower body circumference. Recommendations are made concerning how the hip is defined in measurement practice and within body scanning for clothing product development. Practitioner Summary: The hip girth is an important measurement in garment design, yet its measurement protocol is not currently defined. We demonstrate that body posture during body scanning affects hip circumferences, and that current clothing measurement practices may not define the largest lower body circumference. This paper also provides future measurement practice recommendations.

Dress fit and body image: a thematic analysis of women's accounts during and after trying on dresses.

This study was designed to investigate women's experiences of dress fit and body image. Spontaneous speech of 20 women aged 18-45 years was audio-recorded while they tried on a number of dresses. They were also body-scanned and photographed in their chosen dress and discussed both the scan and the photograph in semi-structured interviews. Data were analysed using inductive thematic analysis and four key themes were found: the slim hourglass ideal, functional aspects of clothes fit, body confidence and clothes fit, and clothes dimensions and size coding. All themes and component sub-themes were ratified in follow-up sessions six months after the original interviews. It was concluded that these women had a complicated relationship with clothes fit and sizing and used well-fitting clothes to increase body confidence, cover perceived flaws, and to try to attain a slender hourglass look. Ideas for future directions for research in these areas are discussed.