ABSTRACT
We studied the importance of changes in plasma protein concentrations in patients with hematologic systemic diseases treated by selective decontamination of the digestive tract. The concentrations of albumin, acute-phase proteins, immunoglobulins and fibronectin were determined by laser nephelometry in 125 serum samples of eight patients. Results obtained allow the following conclusions: 1. There was a correlation between the clinical condition and concentrations of acid alpha-1-glycoprotein, IgG, CRP and fibronectin. These concentrations might be important for assessment of the course of the disease, effectiveness of therapy and the detection of pathogenetic relations. 2. The acid alpha-1-glycoprotein is of particular importance since relations exist between changes in its concentration and therapeutic results as well as the prognosis of the disease.
Subject(s)
Anti-Infective Agents/pharmacology , Immune Tolerance/drug effects , Acute-Phase Proteins/metabolism , Blood Proteins/metabolism , Digestive System/drug effects , Digestive System/microbiology , Hematologic Diseases/blood , Hematologic Diseases/drug therapy , Hematologic Diseases/immunology , Humans , Immune Tolerance/immunology , Infection ControlABSTRACT
A group of 55 hematological patients treated for the last 2.5 years by the method of selective decontamination was evaluated. Though both institutes (Bad Saarow, Hradec Králové) worked on the problem in the same conditions (indications for the treatment, characteristics of patients, basic drugs), many differences in details were found. However, the important clinical results were the same: A statistically significant decrease in infections and duration of fever in treated patients. A survey of therapy complications, surveillance of infections and incidence of microbes are presented. The evaluation showed that future research including microbiological and immunological investigation based on a standard protocol will be useful.
Subject(s)
Intestines/microbiology , Leukemia/drug therapy , Lymphoma/drug therapy , Mouth Mucosa/microbiology , Nalidixic Acid/therapeutic use , Neutropenia/drug therapy , Polymyxins/therapeutic use , Adult , Agranulocytosis , Bacteria, Aerobic/drug effects , Feces/microbiology , Female , Fever/complications , Humans , Intestines/drug effects , Leukemia/complications , Lymphoma/complications , Male , Nalidixic Acid/adverse effects , Neutropenia/complications , Neutropenia/microbiology , Polymyxins/adverse effectsABSTRACT
A survey of potential chemical warfare agents of the NATO and of the injuries caused by them is given. After a short characterization of the course and the symptomatology of the injuries the paper indicates the possibilities of giving medical aid at war and refers to the tasks which are derived from this for the education and continued professional training of medical staff.
