Automatic intraocular lens segmentation and detection in optical coherence tomography images.

We present a new algorithm for automatic segmentation and detection of an accommodative intraocular lens implanted in a biomechanical eye model. We extracted lens curvature and position. The algorithm contains denoising and fan correction by a multi-level calibration routine. The segmentation is realized by an adapted canny edge detection algorithm followed by a detection of lens surface with an automatic region of interest search to suppress non-optical surfaces like the lens haptic. The optical distortion of lens back surface is corrected by inverse raytracing. Lens geometry was extracted by a spherical fit. We implemented and demonstrated a powerful algorithm for automatic segmentation, detection and surface analysis of intraocular lenses in vitro. The achieved accuracy is within the expected range determined by previous studies. Future improvements will include the transfer to clinical anterior segment OCT devices.

Biomechanical eye model and measurement setup for investigating accommodating intraocular lenses.

We present a biomechanical eye model to induce pseudophakic accommodative movement for evaluation of the focal shift of accommodative intraocular lenses. Therefore, an accommodative intraocular lens (IOL) was implanted into freshly enucleated porcine eyes. The eyes were glued into a mechanical apparatus to expand the ciliar body effectuating mechanical accommodation. An optical coherence tomographer was used to measure positional and geometrical changes of the IOL for different levels of expansion. The expansion unit allowed stretching of the globe of several millimeters. With the biomechanical eye model we were able to simulate the mechanical functionality of accommodation as well as to measure the lens vault and change in geometry. Accommodative vault could only be measured with an intact vitreous, indicating that the vitreous plays an important role for the functionality of accommodative IOLs.

Photochromic dynamics of ophthalmic lenses.

We describe and characterize a straightforward test setup for characterizing temporal and spectral dynamics of photochromic spectacle materials. Three measurement examples of contemporary silicate and organic photochromic spectacles are provided. The setup showed a good absolute accuracy of ≤5% of the luminous transmittance (τ(v)) and repeatability of better than 3%. The samples showed different fading times. The sample with the highest dynamic range was the slowest and showed a noticeable change in the transmission spectra during deactivation. The silicate had the lowest dynamic range but also the most homogeneous transmission spectra throughout activation and deactivation. The proposed test device provided accurate results for spectral and temporal dynamics of photochromic materials under realistic conditions.