ABSTRACT
En la presente serie, compuesta por 2011 pacientes estudiados, nuestras observaciones coinciden con lo reportado en otros países, en relación al porcentaje de hallazgo del H.pylory en los casos de gastritis crónica activa, úlcera p éptica gástrica, úlcera péptica duodenal y en la mucosa gástrica histológicamente normal. En el Perú, en pacientes con síntomas del tracto gastrointestinal superior, la infección por H. pylori se encuentra en porcentajes más elevados (84%) que lo reportado en naciones industrializadas. No observamos incremento de la infección con la edad, debido a que ésta, en nuestro medio, se adquiere en edades muy tempranas como hemos demostrado por la prueba de ELISA. La distribución ecológica de la bacteria, es igual en las tres regiones del Perú y sólo en as mujeres de nivel socioeconómico alto, la prevalencia de la infección es menor. El porcentaje de recurrencia después de tratamiento es superior al descrito en países industrializados
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Gastritis/etiology , Helicobacter Infections/epidemiology , Helicobacter pylori , Age Factors , Aged, 80 and over , Altitude , Biopsy , Double-Blind Method , Endoscopy, Digestive System , Enzyme-Linked Immunosorbent Assay , Helicobacter Infections/complications , Helicobacter Infections/diagnosis , Helicobacter Infections/drug therapy , Helicobacter pylori/isolation & purification , Sex Factors , Socioeconomic Factors , Stomach/pathologyABSTRACT
En la presente serie, compuesta por 2011 pacientes estudiados, nuestras observaciones coinciden con lo reportado en otros países, en relación al porcentaje de hallazgo del H.pylory en los casos de gastritis crónica activa, úlcera p éptica gástrica, úlcera péptica duodenal y en la mucosa gástrica histológicamente normal. En el Perú, en pacientes con síntomas del tracto gastrointestinal superior, la infección por H. pylori se encuentra en porcentajes más elevados (84%) que lo reportado en naciones industrializadas. No observamos incremento de la infección con la edad, debido a que ésta, en nuestro medio, se adquiere en edades muy tempranas como hemos demostrado por la prueba de ELISA. La distribución ecológica de la bacteria, es igual en las tres regiones del Perú y sólo en as mujeres de nivel socioeconómico alto, la prevalencia de la infección es menor. El porcentaje de recurrencia después de tratamiento es superior al descrito en países industrializados (AU)
Subject(s)
Adolescent , Adult , Middle Aged , Aged , Humans , Male , Female , Helicobacter Infections/epidemiology , Gastritis/etiology , Helicobacter pylori , Helicobacter Infections/complications , Helicobacter Infections/diagnosis , Helicobacter Infections/drug therapy , Helicobacter pylori/isolation & purification , Endoscopy, Digestive System , Biopsy , Enzyme-Linked Immunosorbent Assay , Stomach/pathology , Sex Factors , Age Factors , Socioeconomic Factors , Altitude , Aged, 80 and over , Double-Blind MethodABSTRACT
The rate of infection by Helicobacter pylori in peruvian dyspeptic patients (84%) is higher than that reported in symptomatic patients from developed countries. Helicobacter pylori infection did not increase with age. The ecological distribution is similar in the three different geographical regions of Peru. Only women of high economic status had significantly lower rates of Helicobacter pylori infection compared to all other groups. The recurrence rate after treatment is higher than that reported from developed countries.
Subject(s)
Gastritis/etiology , Helicobacter Infections/epidemiology , Helicobacter pylori , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Altitude , Biopsy , Double-Blind Method , Endoscopy, Digestive System , Enzyme-Linked Immunosorbent Assay , Female , Helicobacter Infections/complications , Helicobacter Infections/diagnosis , Helicobacter Infections/drug therapy , Helicobacter pylori/isolation & purification , Humans , Male , Middle Aged , Peru/epidemiology , Sex Factors , Socioeconomic Factors , Stomach/pathologyABSTRACT
The rate of infection by Helicobacter pylori in peruvian dyspeptic patients (84
) is higher than that reported in symptomatic patients from developed countries. Helicobacter pylori infection did not increase with age. The ecological distribution is similar in the three different geographical regions of Peru. Only women of high economic status had significantly lower rates of Helicobacter pylori infection compared to all other groups. The recurrence rate after treatment is higher than that reported from developed countries.
ABSTRACT
Activation of glycogen phosphorylase by hormones was examined in hepatocytes isolated from euthyroid and hypothyroid female rats and incubated by Ca2+-free buffer containing 1 mM-EGTA. Basal glycogen phosphorylase activity was decreased in Ca2+-free buffer. However, the activation of hepatocyte glycogen phosphorylase, in the absence of extracellular Ca2+, in response to adrenaline, glucagon or phenylephrine was slightly lower, whereas that by vasopressin was abolished. The activation of glycogen phosphorylase by phenylephrine, adrenaline or isoproterenol (isoprenaline) in hepatocytes from euthyroid rats incubated in the absence of Ca2+ was not accompanied by any detectable increase in total cyclic AMP. The log-dose/response curves for activation of phosphorylase by phenylephrine or low concentrations of adrenaline were the same in hepatocytes from hypothyroid as compared wit euthyroid rats, whereas the response to isoproterenol was greater in hepatocytes from hypothyroid rats. However, the increases in total cyclic AMP accumulation caused by adrenaline or isoproterenol were greater in hepatocytes from hypothyroid rats than in hepatocytes from euthyroid rats. The increases in cyclic AMP accumulation caused by adrenaline or isoproterenol in Ca2+-depleted hepatocytes from hypothyroid rats were blocked by propranolol, a beta-adrenergic antagonist. In contrast, propranolol was only partially effective asan inhibitor of the activation of glycogen phosphorylase by phenylephrine or adrenaline in hepatocytes from hypothyroid rats and ineffective on phosphorylase activation in cells from euthyroid rats. These data indicate that the alpha-adrenergic activation of glycogen phosphorylase is not affected by the absence of extracellular Ca2+, and the extent to which total cyclic AMP was increased by adrenergic amines did not correlate with glycogen phosphorylase activation.
