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Eur J Med Chem ; 160: 82-93, 2018 Dec 05.
Article in English | MEDLINE | ID: mdl-30321803

ABSTRACT

The yeast Candida albicans is an opportunistic fungal pathogen which induces superficial and systemic infections in immunocompromised patients. Adherence to host tissue is critical to its ability to colonise and infect the host. The work presented here describes the synthesis of a small library of aromatic glycoconjugates (AGCs) and their evaluation as inhibitors of C. albicans adherence to exfoliated buccal epithelial cells (BECs). We identified a divalent galactoside, ligand 2a, capable of displacing over 50% of yeast cells already attached to the BECs. Fluorescence imaging indicates that 2a may bind to structural components of the fungal cell wall.


Subject(s)
Candida albicans/drug effects , Epithelial Cells/drug effects , Glycoconjugates/pharmacology , Candida albicans/cytology , Candida albicans/metabolism , Cell Adhesion/drug effects , Dose-Response Relationship, Drug , Epithelial Cells/metabolism , Glycoconjugates/chemical synthesis , Glycoconjugates/chemistry , Humans , Ligands , Microscopy, Confocal , Molecular Structure , Optical Imaging , Structure-Activity Relationship
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