ABSTRACT
Aging is a physiological state in which a progressive decline in organ functions is accompanied by the development of age-related diseases. Resveratrol supplementation has been shown to exert anti-inflammatory and antioxidant effects in various mammalian models of aging. Senescence-accelerated mice (SAM) are commonly used as animal models to investigate the aging process. In the present study, the effects of inflammation, oxidative stress and apoptosis in pancreas of two different types of SAM (SAMR1 or resistant to aging, and SAMP8 or prone to aging) have been analysed, as well as the effect of resveratrol administration (5mg/kg/day) on these parameters in the SAMP8 strain. mRNA expressions of sirtuin 1 and FoxO factors were found to be decreased with aging in SAMP8 mice. An increase in inflammatory status and nuclear-factor kappa B (NFκB) protein expression was also observed in old mice, together with a decrease of anti-apoptotic markers and antioxidant-enzyme activity. Resveratrol administration was able to increase sirtuin 1 mRNA expression, as well as decreasing NFκB expression and reducing the proinflammatory and prooxidant status associated with age. In conclusion, resveratrol was able to modulate the inflammatory, oxidative and apoptotic status related to aging, thereby exerting a protective effect on pancreas age-induced damage.
Subject(s)
Aging/drug effects , Antioxidants/pharmacology , Apoptosis/drug effects , Inflammation/drug therapy , Oxidative Stress/drug effects , Pancreas/drug effects , Stilbenes/pharmacology , Aging/physiology , Animals , Male , Mice , NF-kappa B/metabolism , Pancreas/physiology , RNA, Messenger/analysis , Resveratrol , Sirtuin 1/geneticsABSTRACT
La alergia al látex es motivo de reciente preocupación en el ámbito sanitario debido al aumento de prevalencia. Para preservar la seguridad de los pacientes sensibilizados al látex durante su ingreso hospitalario es imprescindible conocer qué es el látex, qué material sanitario lo contiene y cuál está exento de él, cómo se manifiesta la reacción alérgica y qué medidas se llevarán a cabo para evitarlas. Se describe el material utilizado y las pautas de actuación en un paciente alérgico al látex que ingresa como receptor de un injerto renal (AU)
Subject(s)
Humans , Kidney Transplantation/nursing , Latex Hypersensitivity/nursing , Latex/adverse effects , Risk Groups , Risk Factors , Equipment and Supplies , Nursing Care/standardsABSTRACT
Allergies to latex is a motive for recent worry in the health field due to the increasing prevalence of latex. In order to assure the security of patients sensitive to latex during their hospital stay, it is absolutely necessary to know what latex is, which sanitary products contain it and which do not, as well as how an allergic reaction to latex manifests itself and what are the prescribed methods to carry out in order to avoid these. This article describes the material used and the operating procedures to follow when treating a patient who is allergic to latex and who is in a hospital as the recipient of a kidney implant.
