ABSTRACT
IntroducciónSegún las clasificaciones actuales, el metabolito de mayor interés clínico para valorar la dotación de vitamina D3 es el 25-hidroxivitamina D3 con un intervalo de referencia en 1070ng/ml, aunque muchos autores consideran como deseable valores por sobre 40ng/ml o 100nmol/l. Según estas definiciones, en España tres de cada cuatro personas tendrían carencias de vitamina D3.Material y métodoSe ha utilizado una técnica radioinmunoensayo-CT para el diagnóstico de la 25hidroxivitamina D3 para ver el estatus en la población. Posteriormente, se ha realizado un estudio de casos y controles para conocer la relación entre diferentes enfermedades y carencias de vitamina D3.ResultadosEl 73,2% de los casos se encuentra en rangos considerados aceptables, según la clasificación actual, y el grupo control, mujeres menopáusicas sanas que no recibían ningún tipo de suplemento vitamínico, se encuentra con niveles desde 40ng/ml en un 100%.Discusión y conclusionesSegún nuestro estudio, los niveles de vitamina D3 han cambiado, pasando de una alta prevalencia de insuficiencia de vitamina D3 a rangos aceptables en un 26,8% de la población, con una mediana de 46,2ng/ml, considerando como rango de referencia 1070ng/ml(AU)
IntroductionAccording to current classifications, the metabolite of greatest clinical interest to evaluate vitamin D3 dosage is 25-hydroxyvitamin D3 with a reference interval of approximately 1070ng/ml, although many authors consider values of approximately 40ng/ml or 100nmol/l to be desirable. According to these definitions, three out of four people in Spain would have vitamin D3 deficiency.Material and methodThe RIA-CT technique was used for diagnosis of 25(OH)D3 to determine the population status. Subsequently, a case-control study was performed to evaluate the relationship between distinct diseases and vitamin D3 deficiency.ResultsA total of 73.2% of the cases were found to be within the range considered acceptable, according to the present classification. One hundred percent of the control group and healthy menopausal women who did not receive any kind of vitamin supplement had levels of 40ng/ml or more.Discussion and conclusionsOur results indicate that the prior situation of a high prevalence of vitamin D3 deficiency has improved and that levels are now acceptable in 26.8% of the population, with a mean value of 46.2ng/ml, considering 1070ng/ml as the reference range(AU)
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Cholecalciferol/therapeutic use , Cholecalciferol/pharmacology , Menopause , Avitaminosis/diagnosis , Avitaminosis/therapy , Vitamin D Deficiency/therapy , Case-Control Studies , Cholecalciferol/administration & dosage , Bone Density Conservation Agents/therapeutic useABSTRACT
INTRODUCTION: According to current classifications, the metabolite of greatest clinical interest to evaluate vitamin D(3) dosage is 25-hydroxyvitamin D(3) with a reference interval of approximately 10-70ng/ml, although many authors consider values of approximately 40ng/ml or 100nmol/l to be desirable. According to these definitions, three out of four people in Spain would have vitamin D(3) deficiency. MATERIAL AND METHOD: The RIA-CT technique was used for diagnosis of 25(OH)D(3) to determine the population status. Subsequently, a case-control study was performed to evaluate the relationship between distinct diseases and vitamin D(3) deficiency. RESULTS: A total of 73.2% of the cases were found to be within the range considered acceptable, according to the present classification. One hundred percent of the control group and healthy menopausal women who did not receive any kind of vitamin supplement had levels of 40 ng/ml or more. DISCUSSION AND CONCLUSIONS: Our results indicate that the prior situation of a high prevalence of vitamin D(3) deficiency has improved and that levels are now acceptable in 26.8% of the population, with a mean value of 46.2 ng/ml, considering 10-70 ng/ml as the reference range.
Subject(s)
Cholecalciferol/blood , Cholecalciferol/deficiency , Adolescent , Adult , Aged , Case-Control Studies , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Spain , Young AdultABSTRACT
INTRODUCTION AND OBJECTIVES: The AGEMZA cohort comprises military men whose risk factors were studied in 1985 when they were 20 years old. As these men reached the age of 35 years, we investigated the stability of or changes in anthropometric measures, lipid levels and arterial pressure, and looked for interrelationships between any changes. METHODS: In 2000, we collected new data (by cross-sectional study) on body mass index (BMI), cholesterol, cholesterol fractions, triglycerides and blood pressure, which could be compared with the original data. Persistence or tracking was evaluated using standardized regression coefficients and odds for persistence within the same quintile. Current data were modelled using multivariate regression models. RESULTS: In the 250 subjects studied, significant changes were observed in the following variables: weight +12.1 kg, BMI +3.9 kg/m(2), cholesterol +68.0 mg/dL, HDL cholesterol -5.2 mg/dL, LDL cholesterol +57.9 mg/dL, and triglycerides +76.3 mg/dL. The degree of persistence was high for all variables, except for diastolic blood pressure. Persistence was most pronounced for BMI, cholesterol, and LDL cholesterol. The changes observed indicate an increase in cardiovascular risk that adds to the effect of aging. The change in lipid profile was mainly influenced by the increase in BMI experienced, whereas blood pressure was mainly influenced by the final BMI attained. In addition, being a current smoker was associated with worse cholesterol fractions and triglyceride levels. CONCLUSIONS: Cardiovascular risk factors increase during the third decade of the life. Early evaluation (after adolescence) enables the identification of individuals who will later be at an increased risk. Modifiable risk factors were identified, such as weight increase and smoking. Preventive measures should be designed for these groups.
Subject(s)
Cardiovascular Diseases/epidemiology , Military Personnel , Adult , Disease Progression , Follow-Up Studies , Humans , Male , Risk Factors , Spain , Time FactorsABSTRACT
Introducción y objetivos. La cohorte AGEMZA son varones militares cuyos factores de riesgo fueron estudiados en 1985 a la edad de 20 años. A la edad de 35 años se estudian la antropometría, los lípidos y la presión arterial y se investiga su estabilidad, sus cambios y la interdependencia en su evolución. Métodos. En 2000, se obtuvieron datos (encuesta transversal) que se compararon con los originales: índice de masa corporal (IMC), colesterol y sus fracciones, triglicéridos y presiones arteriales. La persistencia o tracking se evalúa mediante el coeficiente de regresión estandarizado y la permanencia en quintiles. Se crearon modelos de regresión multivariante para los datos actuales. Resultados. Tras estudiar a 250 sujetos, se observaron modificaciones significativas de los siguientes factores: peso, +12,1 kg; IMC, +3,9 kg/m², colesterol, +68,0 mg/dl; colesterol unido a lipoproteínas de alta densidad, -5,2 mg/dl; colesterol unido a lipoproteínas de baja densidad (cLDL), +57,9 mg/dl, y triglicéridos, +76,3 mg/dl. Todos los factores presentaron una persistencia elevada, excepto la presión arterial diastólica. Es más pronunciada la persistencia de IMC, colesterol y cLDL. Estos cambios suponen un peor riesgo cardiovascular independientemente de la diferente edad. El perfil de lípidos se vio influido por el incremento del IMC experimentado y los valores de presión arterial por el IMC alcanzado. Ser fumador activo también se asoció a peores valores de las fracciones de colesterol y triglicéridos. Conclusiones. Durante la tercera década de la vida los factores de riesgo cardiovascular se incrementan. Estudios precoces (en la postadolescencia) permiten identificar sujetos con mayor riesgo posterior. Se constató la influencia en el perfil final de circunstancias modificables (incremento ponderal, tabaquismo). Es razonable planificar medidas preventivas orientadas a estos colectivos
Introduction and objectives. The AGEMZA cohort comprises military men whose risk factors were studied in 1985 when they were 20 years old. As these men reached the age of 35 years, we investigated the stability of or changes in anthropometric measures, lipid levels and arterial pressure, and looked for interrelationships between any changes. Methods. In 2000, we collected new data (by cross-sectional study) on body mass index (BMI), cholesterol, cholesterol fractions, triglycerides and blood pressure, which could be compared with the original data. Persistence or tracking was evaluated using standardized regression coefficients and odds for persistence within the same quintile. Current data were modelled using multivariate regression models. Results. In the 250 subjects studied, significant changes were observed in the following variables: weight +12.1 kg, BMI +3.9 kg/m², cholesterol +68.0 mg/dL, HDL cholesterol -5.2 mg/dL, LDL cholesterol +57.9 mg/dL, and triglycerides +76.3 mg/dL. The degree of persistence was high for all variables, except for diastolic blood pressure. Persistence was most pronounced for BMI, cholesterol, and LDL cholesterol. The changes observed indicate an increase in cardiovascular risk that adds to the effect of aging. The change in lipid profile was mainly influenced by the increase in BMI experienced, whereas blood pressure was mainly influenced by the final BMI attained. In addition, being a current smoker was associated with worse cholesterol fractions and triglyceride levels. Conclusions. Cardiovascular risk factors increase during the third decade of the life. Early evaluation (after adolescence) enables the identification of individuals who will later be at an increased risk. Modifiable risk factors were identified, such as weight increase and smoking. Preventive measures should be designed for these groups
