1.
Bioorg Med Chem Lett
; 14(19): 4931-4, 2004 Oct 04.
Article
in English
| MEDLINE
| ID: mdl-15341954
ABSTRACT
The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R=Me] was examined by the synthesis of (+)- and (-)-1, and two alkyl chain analogs (+)- and (-)-2 (R=n-propyl) and (-)-3 (R=n-octyl) as well as their evaluation in enzymatic and neurite outgrowth assays.