Subject(s)
Amitriptyline/therapeutic use , Depression/drug therapy , Dibenzazepines/therapeutic use , Mianserin/therapeutic use , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
The results of double-blind comparative trials carried out simultaneously in three Finnish hospitals are presented. The antidepressant activity and side-effects of mianserine (ORG GB 94) and amitriptyline were compared. No statistically significant differences were found between the two treatments. It was found, however, that mianserine had clearly less anticholinergic side-effects than amitriptyline.
Subject(s)
Amitriptyline/therapeutic use , Depression/drug therapy , Dibenzazepines/therapeutic use , Mianserin/therapeutic use , Adolescent , Adult , Alanine Transaminase/blood , Alkaline Phosphatase/blood , Amitriptyline/adverse effects , Aspartate Aminotransferases/blood , Clinical Trials as Topic , Double-Blind Method , Humans , Mianserin/adverse effects , Middle Aged , Psychiatric Status Rating Scales , Time FactorsABSTRACT
One hundred patients who in 1963 had attempted self-poisoning and were subsequently admitted to the intoxication ward of a psychiatric hospital were studied twice: immediately after the attempted self-poisoning and 8 years after the attempt. It was found that within the follow-up period a total of nine patients had died, four of whom had committed suicide. The risk of suicide per years is .5%. According to the literature the range of the annual suicide risk is .9% to 2.5%.
