Radiographic assessment of the thickness lost from polyethylene tibial inserts that had been sterilized differently.

BACKGROUND: Archived serial radiographs of knee replacements provide indirect evidence of the clinical performance of ultra-high molecular weight polyethylene tibial bearings. Our purpose was to determine the loss of thickness in polyethylene tibial inserts that were of the same design but had been sterilized differently. METHODS: Four hundred and sixteen knees with an Anatomic Modular Knee primary total knee replacement had five to eighteen years of follow-up and a posterior cruciate ligament-retaining polyethylene tibial insert that had been sterilized with either gamma radiation in air (from 1987 to 1993) or gamma radiation in an inert gas (from 1993 to 1995), or by means of a nonirradiation gas-plasma method (from 1995 to 2001). Readings were taken from 1975 weight-bearing anteroposterior radiographs of the knee on which the top surface of the metal tibial tray had nearly projected as a line. In each tibiofemoral compartment, loss of polyethylene thickness was calculated as the standard thickness of the insert minus the measured magnification-corrected thickness. For each sterilization method, thickness loss was plotted versus the corresponding follow-up time, and a mixed linear regression model was used to quantify the change in thickness over time. Multiple linear regression analysis was used to determine whether loss of thickness was associated with implant factors, patient variables, and early postoperative limb alignment. RESULTS: According to the mixed model regression coefficients, loss of medial compartment thickness was greatest for inserts that had been sterilized with gamma radiation in air (0.15 mm/yr), least for those sterilized with gamma radiation in an inert gas (0.02 mm/yr), and of an intermediate magnitude for those sterilized with a nonirradiation method (0.06 mm/year); loss of lateral compartment thickness ranged from 0.03 to 0.06 mm/yr. Notably, no insert irradiated in an inert gas showed a loss of thickness of >1 mm, and no nonirradiated insert showed a loss of >2 mm. Loss of medial compartment thickness in inserts sterilized with radiation in air increased significantly with a greater polyethylene shelf age, lesser patient age, and more varus alignment of the limb in the early postoperative period (p < 0.01). CONCLUSIONS: In this total knee design, tibial polyethylene performance improved markedly after discontinuation of the gamma radiation in air sterilization technique. Future concerns are that bearings sterilized with radiation in an inert gas may oxidize in vivo and develop fatigue wear because of free radicals generated during sterilization with radiation and that nonirradiated bearings may undergo greater losses in thickness from routine burnishing since they lack the cross-linking that accompanies sterilization with radiation.

Ultrasound in the diagnosis of a median neuropathy in the forearm: case report.

BACKGROUND: Electrodiagnostic studies are traditionally used in the diagnosis of focal neuropathies, however they lack anatomical information regarding the nerve and its surrounding structures. The purpose of this case is to show that high-resolution ultrasound used as an adjunct to electrodiagnostic studies may complement this lack of information and give insight to the cause. CASE PRESENTATION: A 60-year-old male patient sustained a forearm traction injury resulting in progressive weakness and functional loss in the first three digits of the right hand. High-resolution ultrasound showed the presence of an enlarged nerve and a homogenous soft-tissue structure appearing to engulf the nerve. The contralateral side was normal. Surgery revealed fibrotic bands emanating from the flexor digitorum profundus muscle compressing the median nerve thus confirming the ultrasound findings. CONCLUSION: A diagnostically challenging case of median neuropathy in the forearm is presented in which high-resolution ultrasound was valuable in establishing an anatomic etiology and directing appropriate management.

A randomized prospective evaluation of outcomes after total hip arthroplasty using cross-linked marathon and non-cross-linked Enduron polyethylene liners.

Cross-linked liners were introduced with the promise that they would substantially reduce polyethylene wear. In 1999, our institution initiated a prospective study to compare the outcome of total hip arthroplasty patients who were randomized to non-cross-linked Enduron liners with that of total hip arthroplasty patients who were randomized to Marathon polyethylene liners that had been cross-linked with 5 Mrad (50 kGy) of gamma-irradiation and heat-treated to eliminate free radicals. At a mean follow-up of 5.7 years, the clinical outcomes among the Marathon and Enduron liners were similar. However, the mean wear rate was 0.01 +/- 0.07 mm/y for the Marathon group, which represents a 95% reduction compared with the mean wear rate of 0.19 +/- 0.12 mm/y for the Enduron group. In addition, the incidence of osteolysis was lower in the Marathon group.

Osteolysis after total knee arthroplasty: influence of tibial baseplate surface finish and sterilization of polyethylene insert. Findings at five to ten years postoperatively.

BACKGROUND: Debris displaced from the articular and backside surfaces of the polyethylene inserts of modular tibial components is considered a chief cause of osteolysis at the sites of total knee arthroplasties. One design of total knee replacement featured changes, over time, in the proximal surface roughness of the tibial baseplate and the method of sterilization of the polyethylene insert. We hypothesized that polishing the baseplate surface and sterilizing the insert with means other than gamma radiation in air had reduced the prevalence of osteolysis. METHODS: Three hundred and sixty-five posterior cruciate ligament-retaining Anatomic Modular Knee primary total knee arthroplasties were performed in 300 patients from 1987 to 1998. Anteroposterior and lateral radiographs of the knees were made within a five to ten-year postoperative interval. Two arthroplasty specialists independently examined the radiographs for evidence of osteolysis (defined as any nonlinear region of cancellous bone loss with delineable margins). RESULTS: Osteolysis was identified in 34% (eighty-two) of 242 knees treated with an insert that had been gamma-irradiated in air and affixed to a rough baseplate surface, and it was identified in 9% (nine) of ninety-eight knees treated with an insert that had been gamma-irradiated in an inert gas, or had not been irradiated, and joined to a polished surface. Osteolysis was associated with six factors, including one related to the patient (male gender), one related to the tibial baseplate (the proximal surface finish), three related to the polyethylene insert (the material from which it was machined, the sterilization method, and the shelf age), and one related to the technique (hyperextension of the femoral component relative to the tibial component). CONCLUSIONS: In this design of a total knee prosthesis, polishing the tibial baseplate counterface and implementing a more contemporary sterilization practice (as opposed to gamma radiation in air) noticeably diminished but did not eliminate osteolysis.

The effect of total hip arthroplasty cup design on polyethylene wear rate.

Using 743 total hip arthroplasties that included 6 hemispheric porous-coated cup designs, this study used a multiple linear regression to identify those factors that influenced polyethylene wear rates. Wear rates for each hip were based on serial head penetration measurement made with computer-assisted techniques. Implant factors associated with an increased wear rate included terminal sterilization with a non-cross-linking chemical surface treatment, a 4-mm lateralized liner, a cobalt-chrome femoral head, and a longer shelf life for liners gamma-irradiated in air. After accounting for these implant characteristics and patient factors, wear rates among the 6 cup designs were not significantly different (P = .89). Although polyethylene wear is frequently characterized for specific implant designs, this study demonstrated that there are several common factors that influence polyethylene wear rates.