ABSTRACT
The article analyzes properties of potassium and magnesium, which may exert vasodilatory, anti-inflammatory, anti-ischemic, antiaggregant, and antiarrhythmic effects. These are extremely important microelements and potentially beneficial therapeutic agents for treatment of cardiovascular diseases.
Subject(s)
Magnesium Deficiency , Anti-Arrhythmia Agents , Cardiovascular Diseases , Humans , Magnesium , PotassiumABSTRACT
Nicorandil, opener of potassium channels, was studied in Russia and abroad. Its cardioprotective, anti-ischemic, pharmacokinetic and pharmacodynamic properties are reviewed as well as side effects and area of application in patients with stable coronary heart disease (CHD). The trial have found efficacy of nicorandil in prevention of anginal attacks. Also, the drug increases exercise tolerance. Administration of nicorandil is indicated before intervention on coronary arteries for reproduction of the effect of myocardial preconditioning. Nicorandil is recommended for treatment of patients with chronic stable coronary heart disease.
Subject(s)
Cardiotonic Agents , Coronary Disease/drug therapy , Nicorandil , Administration, Oral , Biological Availability , Cardiotonic Agents/pharmacokinetics , Cardiotonic Agents/pharmacology , Cardiotonic Agents/therapeutic use , Clinical Trials as Topic , Humans , Nicorandil/pharmacokinetics , Nicorandil/pharmacology , Nicorandil/therapeutic use , Treatment OutcomeABSTRACT
The paper demonstrates the results of the application of laser dopplerometry supplemented with respiratory, thermal and occlusive functional tests, as a new non-invasive method of microcirculation evaluation. Initially the majority of patients have spastic or hyperemic microcirculation disturbances in the skin of the fingers. Functional tests allow specification of the mechanisms of these disturbances, such as microhemodynamic inertness and the suppression of slow circulatory rhythms, which demonstrate the presence of myogenic tonus disorder and prove that vibration has direct influence on vascular wall cells. The manifestation of neurogenic component is the dominance of sympatic vasomotor reflex. The paper also demonstrates the dominance of vasoconstrictor effect over vasodilatatory one.
