Postoperative ileus after para-aortic lymphadenectomy: a prospective study.

OBJECTIVE: To evaluate GI symptoms in patients submitted to systematic para-aortic lymphadenectomy (PALN) and to compare them in a contemporary series of patients only submitted to systematic pelvic lymphadenectomy (PLN). METHODS: A prospective study of 51 consecutive patients submitted to systematic (minimum number of aortic nodes removed > or =10) laparotomic para-aortic lymphadenectomy for any gynecological cancer. The following parameters have been monitored prospectively: nausea and vomiting, bowel movements, nasogastric tube insertion or reinsertion, the time of removal of the nasogastric tube, duration of ileus, time to first passage of stool, regular diet consumption and postoperative stay and complications. RESULTS: Twenty-three of 46 valuable patients (50%) submitted to systematic para-aortic lymphadenectomy complain of GI symptoms during recovery and 2 more cases have been readmitted for the appearance of nausea and vomiting with respect to 3 cases (5%) in the group of only pelvic lymphadenectomies (p=0.00001). According to multivariate analysis, the main determinant of post/operative GI dysfunction is the systematic aortic lymphadenectomy. Twenty-two out of a total of 28 symptomatic patients (78.6%) have accused mild symptoms and have been therefore treated by fasting, by intravenous fluid administration and by anti-emetic drugs. Out of the six remaining patients, three patients (10.7%) have been classified as moderate cases because they have required the insertion of a nasogastric tube for gastric decompression, whereas in the remaining refractory patients (10.7%, severe cases) prokinetics drugs have been used. An exploratory laparotomy has never been performed. CONCLUSIONS: GI dysfunction symptoms are very common in patients submitted to systematic para-aortic lymphadenectomy. However, only 20% of the patients complain about moderate/severe symptoms. In these cases, we strongly recommend a conservative management.

An outbreak of hepatogenous photosensitization in sheep grazing Tribulus terrestris in Argentina.

An outbreak of hepatogenous photosensitization occurred in 40% of sheep grazing Tribulus terrestris in southern Buenos Aires province. Postmortem examinations revealed diffuse jaundice and ochre discoloration of the liver. Histopathological liver lesions consisted of fibroplasia, periductular lamellar fibrosis, hyperplasia of small bile ducts and diffuse swelling of hepatocytes. A crystalloid material was observed in some bile ducts. Aspartate aminotransferase and gamma glutamyltransferase serum activities were elevated in all tested animals while serum bilirubin content was elevated only in the most severely affected sheep. These findings are consistent with reports of geeldikkop, a photosensitivity of sheep which occurs in South Africa and Australia.