1.
Org Biomol Chem
; 7(13): 2681-4, 2009 Jul 07.
Article
in English
| MEDLINE
| ID: mdl-19532982
ABSTRACT
Gene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.