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2.
Epilepsy Behav ; 102: 106655, 2020 01.
Article in English | MEDLINE | ID: mdl-31812902

ABSTRACT

OBJECTIVE: Perampanel (PER) has been shown to be effective as an adjunctive therapy for controlling refractory focal-onset seizures (FOS). However, the information as early add-on for the treatment of FOS in the clinical practice is still scarce and must be further assessed. METHODS: An observational prospective study was conducted to evaluate the effectiveness of early add-on PER, assessed as 50% responders (seizure frequency reduced by at least 50% during the last 3 months as compared with baseline) rate at 6 and 12 months, in patients with FOS in the routine clinical practice of Spain. RESULTS: One hundred and thirteen patients (mean age: 40.3 years, 51.3% male) with FOS received PER as early add-on (1st add-on: 37.2% and 2nd: 62.8%) for a mean exposure of 11 months (mean PER dose: 6.3 mg/day at month 12). At 6 months, 50.4% and 20.4% of the patients were responders and seizure-free (respectively) relative to baseline (3 months prior to PER initiation), and at 12 months, 68.1% and 26.5% of the patients were responders and seizure-free (respectively), relative to baseline (3 months prior to PER initiation). The retention rate at 6 and 12 months was 83.2% and 80.5%, respectively. The percentage of seizure-free patients at 12 months was significantly (p = 0.033) higher when PER was added as first vs. second add-on. The number of concomitant antiepileptic drugs (AEDs) was significantly reduced from baseline to 6 and 12 months (p = 0.001). Treatment was simplified in 23.9% of patients at the end of the observation period. Drug-related adverse events (AEs), most mild or moderate, were reported in 30.1% of patients, with irritability (8%) and dizziness (7.1%) as the most frequent ones. CONCLUSIONS: This is the first observational, prospective study to evaluate efficacy and safety of early adjunctive treatment with PER in patients with focal epilepsy at 12 months. Perampanel demonstrated a good efficacy and safety profile when used at a median dose of 6 mg/day, regardless of the combination with other AEDs. Adverse events were mild or moderate, with dizziness being the most frequent one.


Subject(s)
Anticonvulsants/administration & dosage , Epilepsy/drug therapy , Epilepsy/epidemiology , Pyridones/administration & dosage , Seizures/drug therapy , Seizures/epidemiology , Adult , Anticonvulsants/adverse effects , Dizziness/chemically induced , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Nitriles , Prospective Studies , Pyridones/adverse effects , Spain/epidemiology , Treatment Outcome , Young Adult
3.
Reumatol. clín. (Barc.) ; 11(1): 41-44, ene.-feb. 2015. ilus
Article in Spanish | IBECS | ID: ibc-132362

ABSTRACT

La mielitis transversa es una inflamación focal poco frecuente de la médula espinal. Su etiología es múltiple y entre ellas se encuentran las enfermedades autoinmunes, incluyendo principalmente el lupus eritematoso sistémico y el síndrome de Sjögren. Su presentación clínica puede ser de forma aguda o subaguda, con peor pronóstico en la mielitis transversa aguda. Un diagnóstico precoz y tratamiento intensivo desde el inicio es de gran importancia en la evolución de este tipo de pacientes. Presentamos 3 casos con mielitis transversa asociados a enfermedades autoinmunes y discutimos sus distintas manifestaciones clínicas, la asociación a autoanticuerpos, las imágenes radiológicas, el tratamiento y el pronóstico (AU)


Transverse myelitis is a rare focal inflammation of the spinal cord. Multiple etiologies have been identified including autoimmune diseases, mainly systemic lupus erythematosus and Sjögren’ syndrome. It can occur in an acute or subacute clinical onset, with the acute presentation having a worse prognosis. An early diagnosis and intensive treatment are important features recommended in these patients. We present three cases with transverse myelitis associated with autoimmune diseases. We discuss different clinical manifestations, association with autoantobodies, radiologic findings, and therapeutic and prognostic issues (AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Myelitis, Transverse/complications , Myelitis, Transverse/diagnosis , Myelitis, Transverse/therapy , Sjogren's Syndrome/complications , Sjogren's Syndrome/diagnosis , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Prognosis , Myelitis, Transverse/drug therapy , Myelitis, Transverse/physiopathology , Myelitis, Transverse , Lupus Erythematosus, Systemic/drug therapy , Lupus Erythematosus, Systemic/physiopathology , Lupus Erythematosus, Systemic , Early Diagnosis , Magnetic Resonance Imaging/methods
4.
Reumatol Clin ; 11(1): 41-4, 2015.
Article in English, Spanish | MEDLINE | ID: mdl-24913964

ABSTRACT

Transverse myelitis is a rare focal inflammation of the spinal cord. Multiple etiologies have been identified including autoimmune diseases, mainly systemic lupus erythematosus and Sjögren' syndrome. It can occur in an acute or subacute clinical onset, with the acute presentation having a worse prognosis. An early diagnosis and intensive treatment are important features recommended in these patients. We present three cases with transverse myelitis associated with autoimmune diseases. We discuss different clinical manifestations, association with autoantobodies, radiologic findings, and therapeutic and prognostic issues.


Subject(s)
Lupus Erythematosus, Systemic/diagnosis , Myelitis, Transverse/etiology , Sjogren's Syndrome/diagnosis , Adult , Female , Humans , Lupus Erythematosus, Systemic/complications , Middle Aged , Myelitis, Transverse/diagnosis , Sjogren's Syndrome/complications
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