ABSTRACT
La hiperhidrosis focal primaria (HH) es un trastorno que consiste en sudoración que excede lo requerido para la termorregulación y afecta a 3 de cada 100 personas en la población general. Es considerada una enfermedad con alto impacto en la calidad de vida. La fisiopatología involucra el eje hipotálamo- sistema nervioso autónomo. A lo largo de la historia se han descrito múltiples terapias médicas y quirúrgicas con resultados variables. En la literatura se evidencia un vacío en el conocimiento acerca de la simpatectomía torácica (ST) y su utilidad en el contexto de HH. En miras a mejorar la calidad de vida de estos pacientes, realizamos una revisión cuidadosa de la literatura disponible actualmente, encontrando que la ST es un procedimiento seguro y efectivo, con altas tasas de éxito y satisfacción en estos pacientes.
Primary focal hyperhidrosis (HH) is a disorder consisting of sweating in excess of that required for thermoregulation and affects 3 out of 100 people in the general population. It is considered a disease with a high impact on quality of life. Pathophysiology involves the hypothalamic-autonomic nervous system axis. Throughout history, multiple medical and surgical therapies have been described with variable results. The literature shows a gap in knowledge about thoracic sympathectomy and its usefulness in the context of HH. To improve the quality of life of these patients, we carried out a careful review of the currently available literature, finding that ST is a safe and effective procedure, with high rates of success and satisfaction in these patients.
Subject(s)
HumansABSTRACT
BACKGROUND: Seizure relapses are the leading cause of admission to emergency rooms (ER) in people with epilepsy. OBJECTIVE: To analyze administrative and clinical factors associated with the duration between seizure relapses in people with epilepsy admitted to the Neurological Institute of Colombia (Medellin) between July 2018 and July 2019. MATERIALS AND METHODS: A retrospective follow-up study of 156 patients over 18â¯years old, diagnosed with epilepsy, and treated for over a year. The outcome variable was the time between seizure relapses, identified through the record of ER attendances. In addition, difficulties in the prescription filling process (delay, omission, or brand change) and clinical characteristics were analyzed as potential associated influence factors. The statistical analysis was performed using the Prentice, Williams & Peterson-Gap Time survival model for recurrent events. Finally, Adjusted Hazard Ratios (aHR) with 95% confidence intervals (95%CI) are also presented. RESULTS: One hundred fifty-six patients were analyzed. Their average age of diagnosis was 15.5â¯years (SDâ¯=â¯22.5), the median number of monthly seizures was 3 (SDâ¯=â¯9.3), and 50.6% were women. Moreover, difficulties in the prescription filling process were associated with a time reduction between seizure relapses (aHRâ¯=â¯2.61; 95%CI 1.49-4.57), showing a similar impact as having a history of three or four types of events (aHRâ¯=â¯2.96; 95%CI 1.23-7.12) and neuropsychiatric comorbidity (aHRâ¯=â¯1.89; 95%CI 1.04-3.54). CONCLUSION: Neuropsychiatric comorbidity, history of several types of events, and experiencing difficulties with prescription filling are associated with lower benefit from treatment to control seizure relapses.
Subject(s)
Epilepsies, Partial , Epilepsy, Generalized , Epilepsy , Adolescent , Anticonvulsants/therapeutic use , Carbamazepine/therapeutic use , Colombia/epidemiology , Emergency Service, Hospital , Epilepsies, Partial/drug therapy , Epilepsy/drug therapy , Epilepsy/therapy , Epilepsy, Generalized/drug therapy , Female , Follow-Up Studies , Humans , Recurrence , Retrospective Studies , Seizures/drug therapy , Seizures/therapyABSTRACT
INTRODUCCIÓN: La falla cardiaca, es un síndrome clínico habitualmente progresivo que con frecuencia comienza como disfunción sistólica ventricular izquierda y culmina con manifestaciones clínicas diversas de fallo de bomba y bajo gasto cardiaco hasta la muerte. OBJETIVO: Caracterizar los factores de riesgo que están asociados al desarrollo de disfunción sistólica ventricular izquierda y falla cardiaca secundaria como parte del espectro del síndrome de falla cardiaca en la población de Barranquilla-Colombia. MATERIALES Y MÉTODOS: Se realizó un estudio descriptivo de corte transversal con fuente secundaria de un estudio de salud global en la ciudad de Barranquilla-Colombia, en el que se hizo análisis univariado y bivariado para describir factores de riesgo asociados a la disfunción sistólica ventricular izquierda. RESULTADOS: Se obtuvieron las prevalencias de cuatro factores de riesgo asociados al desarrollo de disfunción sistólica ventricular izquierda: hipertensión arterial 29.7%, obesidad 26.5%, hiperglucemia 4.6%, hipercolesterolemia 8.2% en pacientes mayores de 40 años los cuales tienen mayor riesgo. DISCUSIÓN: Este estudio buscó llamar la atención sobre la disfunción sistólica ventricular izquierda, como una condición de descripción relativamente reciente y de potencial impacto en la salud de las poblaciones y los recursos de los sistemas de salud. CONCLUSIONES: La prevalencia de los factores de riesgo para este estado pre-clínico podría llegar a ser alta y estos pacientes ameritarían, según recomendación de cierta evidencia, tamización para disfunción sistólica ventricular izquierda, así como estudios adicionales son requeridos
INTRODUÇÃO: A insuficiência cardíaca é uma síndrome clínica habitualmente progressiva que, muitas vezes começa como disfunção sistólica ventricular esquerda e termina com diversas manifestações clínicas de falha da bomba e baixo débito cardíaco até a morte. OBJETIVO: Caracterizar os fatores de risco que estão associados ao desenvolvimento da disfunção sistólica ventricular esquerda e insuficiência cardíaca secundária como parte do espectro da síndrome de insuficiência cardíaca na população de Barranquilla-Colômbia. MATERIAIS E MÉTODOS: Realizou-se um estudo descritivo de corte transversal, fonte secundária de um estudo da saúde global na cidade de Barranquilla-Colômbia, e foi realizada uma análise univariada e bivariada para descrever os fatores de risco associados à disfunção sistólica ventricular esquerda. RESULTADOS: Foram obtidas as prevalências de quatro fatores de risco associados ao desenvolvimento da disfunção sistólica ventricular esquerda: hipertensão arterial 29.7%, obesidade 26.5%, hiperglicemia 4.6%, hipercolesterolemia 8.2%, nos pacientes acima de 40 anos, os quais têm mais risco. DISCUSSÃO: Este estudo buscou chamar a atenção sobre a disfunção sistólica ventricular esquerda, como uma condição de descrição relativamente recente e de impacto potencial na saúde das populações e os recursos dos sistemas de saúde. CONCLUSÕES: A prevalência de fatores de risco para este estado pré-clínico poderia tornar-se alta, e estes doentes precisariam segundo a recomendação de algumas evidências, rastreio para disfunção sistólica ventricular
INTRODUCTION: Heart failure is a habitually progressive clinical syndrome that frequently starts as left ventricular systolic dysfunction and culminates with diverse clinical manifestations of pump failure and low cardiac output and even death. OBJECTIVE: The research sought to characterize the risk factors associated to the development of left ventricular systolic dysfunction and secondary heart failure as part of the spectrum of the heart failure syndrome in the population of Barranquilla-Colombia. MATERIALS AND METHODS: A cross-sectional descriptive study was conducted with secondary source from a global health study in the city of Barranquilla-Colombia, which performed univariate and bivariate analysis to describe risk factors associated to left ventricular systolic dysfunction. RESULTS: The study obtained the prevalence of four risk factors associated to the development de left ventricular systolic dysfunction: arterial hypertension (29.7%), obesity (26.5%), hyperglycemia (4.6%), and hypercholesterolemia (8.2%) in patients over 40 years of age, who are at higher risk. DISCUSSION: This study sought to draw attention on the left ventricular systolic dysfunction, as a condition of relatively recent description and of potential impact on the health of populations and the resources of health systems. CONCLUSIONS: The prevalence of risk factors for this pre-clinical state could be high and these patients would merit, per recommendation of certain evidence, screening for left ventricular systolic dysfunction, as well as additional studies are required
