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2.
Rev Esp Sanid Penit ; 16(1): 3-10, 2014.
Article in English | MEDLINE | ID: mdl-24615372

ABSTRACT

AIM: The aim of the study was to ascertain the opinions of both inmates and staff of prison establishments about the use of coercive measures justified for clinical reasons for people with mental health problems and about the need to create protocols to regulate the application of these measures. METHOD: These opinions were gathered in a Qualitative Study with Focus Groups (prison inmates and prison staff) from the Granada Penitentiary Centre and the Alicante Penitentiary Psychiatric Hospital, both in Spain. RESULTS: The results showed that forced medication is the most commonly used coercive measure in these institutions. The inmates did not understand and rejected the use of this measure, above all because they were poorly informed about their illness and the medication required to treat it. The staff however defended the benefits of psychiatric medicine, even when administered without the patient's consent. CONCLUSIONS: Both inmates and staff agreed that it would be useful to have a protocol regulating the use of coercive measures. The study has also identified a number of important factors that could help to reduce the need for coercive measures or make their use unnecessary.


Subject(s)
Attitude of Health Personnel , Coercion , Hospitals, Psychiatric , Inpatients/psychology , Patient Acceptance of Health Care , Patient Rights , Prisoners/psychology , Caregivers , Focus Groups , Hospitals, Psychiatric/ethics , Hospitals, Psychiatric/standards , Humans , Informed Consent , Mental Health Services/ethics , Mental Health Services/standards , Prisons/ethics , Prisons/standards , Qualitative Research , Spain
3.
Biomed Res Int ; 2014: 928740, 2014.
Article in English | MEDLINE | ID: mdl-24563866

ABSTRACT

We have studied the use of coercive medical measures (forced medication, isolation, and mechanical restraint) in mentally ill inmates within two secure psychiatric hospitals (SPH) and three regular prisons (RP) in Spain. Variables related to adopted coercive measures were analyzed, such as type of measure, causes of indication, opinion of patient inmate, opinion of medical staff, and more frequent morbidity. A total of 209 patients (108 from SPH and 101 from RP) were studied. Isolation (41.35%) was the most frequent coercive measure, followed by mechanical restraint (33.17%) and forced medication (25.48%). The type of center has some influence; specifically in RP there is less risk of isolation and restraint than in SPH. Not having had any previous imprisonment reduces isolation and restraint risk while increases the risk of forced medication, as well as previous admissions to psychiatric inpatient units does. Finally, the fact of having lived with a partner before imprisonment reduces the risk of forced medication and communication with the family decreases the risk of isolation. Patients subjected to a coercive measure exhibited a pronounced psychopathology and most of them had been subjected to such measures on previous occasions. The mere fact of external assessment of compliance with human rights slows down the incidence of coercive measures.


Subject(s)
Hospitals, Psychiatric , Mentally Ill Persons/psychology , Prisons , Adult , Attitude , Female , Humans , Male
4.
Rev. esp. sanid. penit ; 16(1): 3-10, 2014. tab
Article in Spanish | IBECS | ID: ibc-121244

ABSTRACT

Objetivos: El estudio ha pretendido conocer por un lado la opinión de personas internas en establecimientos penitenciarios, y por otro lado, la opinión de los funcionarios de estas instituciones sobre el uso de medidas coercitivas por indicación clínica en personas con problemas de salud mental y sobre la necesidad de creación de protocolos de actuación para la aplicación de estas medidas. Metodología: Estudio cualitativo que ha utilizado la técnica de Grupos Focales llevados a cabo con internos y funcionarios del Centro Penitenciario de Granada y del Hospital Psiquiátrico Penitenciario de Alicante, España. Resultados: Los resultados demuestran que la medida coercitiva más utilizada en estas instituciones es la medicación forzosa. Las personas internas no comprenden y rechazan la utilización de esta medida, sobre todo porque están mal informadas sobre su enfermedad y su tratamiento farmacológico, pero los profesionales abogan por los beneficios de la medicación psiquiátrica, aunque sea de forma involuntaria. Conclusiones: Tanto usuarios como profesionales están de acuerdo con la utilidad de la existencia de un protocolo de actuación para la aplicación de medidas coercitivas. Este estudio ha hallado importantes factores que podrían ayudar a disminuir la utilización de medidas coercitivas o incluso evitarlas (AU)


Aim: The aim of the study was to ascertain the opinions of both inmates and staff of prison establishments about the use of coercive measures justified for clinical reasons for people with mental health problems and about the need to create protocols to regulate the application of these measures. Method: These opinions were gathered in a Qualitative Study with Focus Groups (prison inmates and prison staff) from the Granada Penitentiary Centre and the Alicante Penitentiary Psychiatric Hospital, both in Spain. Results: The results showed that forced medication is the most commonly used coercive measure in these institutions. The inmates did not understand and rejected the use of this measure, above all because they were poorly informed about their illness and the medication required to treat it. The staff however defended the benefits of psychiatric medicine, even when administered without the patient's consent. Conclusions: Both inmates and staff agreed that it would be useful to have a protocol regulating the use of coercive measures. The study has also identified a number of important factors that could help to reduce the need for coercive measures or make their use unnecessary (AU)


Subject(s)
Humans , Male , Female , Prisons/organization & administration , Prisons/standards , Prisons , Prisoners/legislation & jurisprudence , Prisoners/psychology , Hospitals, Psychiatric/organization & administration , Hospitals, Psychiatric , Mental Health/standards , Clinical Protocols/standards , Schizophrenia/epidemiology , Hospitals, Psychiatric/standards , Hospitals, Psychiatric/trends , Patient Rights/standards , Patient Rights/trends , 25783/methods , 25783/statistics & numerical data , Informed Consent/standards
5.
Nutr. hosp ; 26(6): 1231-1235, nov.-dic. 2011.
Article in Spanish | IBECS | ID: ibc-104793

ABSTRACT

Las situaciones que plantean problemas éticos en relación con la nutrición y la hidratación son muy frecuentes hoy día, principalmente a nivel hospitalario tanto en pacientes terminales como en otro tipo de pacientes que precisen de hidronutrición. En este artículo se pretende analizar las sencillas en sus fundamentos, a la luz de valores éticos ampliamente aceptados, para intentar enunciar un modo de actuación claro que ayude en su resolución a los clínicos que han de tomar estas difíciles decisiones. Las situaciones problema analizadas incluyen, entre otras, si la hidratación y la nutrición deben considerarse medidas terapéuticas o cuidados básicos, y si presentan iguales aspectos éticos la nutrición enteral y la parenteral (AU)


Conditions that pose ethical problems related to nutrition and hydration are very common now days, particularly within Hospitals among terminally ill patients and other patients who require nutrition and hydration. In this article we intend to analyze some circumstances, according to widely accepted ethical values, in order to outline a clear action model to help clinicians in making such difficult decisions. The problematic situations analyzed include: should hydration and nutrition be considered basic care or therapeutic measures?, and the ethical aspects of enteral versus parenteral nutrition (AU)


Subject(s)
Humans , Nutritional Support/ethics , Fluid Therapy/ethics , Decision Making/ethics , Basic Health Services , Bioethical Issues , Intubation, Gastrointestinal/ethics , Treatment Refusal/ethics
6.
Nutr Hosp ; 26(6): 1231-5, 2011.
Article in Spanish | MEDLINE | ID: mdl-22411365

ABSTRACT

Conditions that pose ethical problems related to nutrition and hydration are very common nowdays, particularly within Hospitals among terminally ill patients and other patients who require nutrition and hydration. In this article we intend to analyze some circumstances, according to widely accepted ethical values, in order to outline a clear action model to help clinicians in making such difficult decisions. The problematic situations analyzed include: should hydration and nutrition be considered basic care or therapeutic measures?, and the ethical aspects of enteral versus parenteral nutrition.


Subject(s)
Ethics, Medical , Fluid Therapy/ethics , Nutritional Support/ethics , Humans , Intubation, Gastrointestinal , Parenteral Nutrition/ethics
7.
Hernia ; 10(1): 87-9, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16283074

ABSTRACT

Parapubic hernia is a rare entity, the aetiology of which is usually associated with pelvic surgery, traumatisms and bone malformations. Treatment is difficult because the defect is usually limited by altered fibrotic anatomical planes. We present a case of incisional pubic hernia in a patient with congenital bladder exstrophy and multiple surgeries for pelvic reconstruction, who was treated using a plasty combined with a double intra-abdominal/supra-aponeurotic mesh. The therapeutic possibilities are described for the laparoscopic and open approaches in the management of these complex hernias.


Subject(s)
Bladder Exstrophy/epidemiology , Hernia, Ventral/surgery , Adult , Bladder Exstrophy/surgery , Female , Hernia, Ventral/etiology , Humans , Hysterectomy , Ilium/surgery , Surgical Mesh , Tomography, X-Ray Computed , Urogenital Surgical Procedures , Vagina/surgery
8.
Surg Endosc ; 19(2): 184-7, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15573242

ABSTRACT

BACKGROUND: Lumbar hernias are uncommon defects of the posterior abdominal wall. Surgical treatment is still controversial in these cases. The aim of this study was to compare outcome and costs of the laparoscopic approach vs the open method. METHODS: We conducted a prospective nonrandomized study of 16 patients who underwent operation for secondary lumbar hernia between January 1997 and January 2003. Nine were treated via the laparoscopic approach and seven with an open technique. The following variables were analyzed: clinical data, hospital data (operating time and length of stay), patient comfort (consumption of analgesics and time to return to normal activities), and recurrences. Hospital costs were also analyzed. RESULTS: There were no differences between the two groups in terms of age and history, although the defects of the patients in the laparoscopic group were smaller. Mean operating time, postoperative morbidity, mean hospital stay, consumption of analgesics, and time to return to normal activities were significantly lower in the laparoscopic group (p < 0. 01). No were there any statistical differences between the two types of surgical procedure in terms of hospital costs. However, the final cost did show differences when expenses for readmissions and recurrences were taken into account (p < 0.01). CONCLUSION: The laparoscopic approach to secondary lumbar hernia repair is more efficient and more profitable than the traditional open technique.


Subject(s)
Digestive System Surgical Procedures/methods , Hernia, Abdominal/surgery , Laparoscopy , Aged , Costs and Cost Analysis , Digestive System Surgical Procedures/economics , Female , Hernia, Abdominal/economics , Hospitalization/economics , Humans , Intraoperative Complications/epidemiology , Laparoscopy/economics , Male , Middle Aged , Prospective Studies , Quality of Life , Spain , Surgical Mesh , Treatment Outcome
9.
Rev. esp. sanid. penit ; 5(3): 92-100, sept.-dic. 2003. tab
Article in Spanish | IBECS | ID: ibc-138152

ABSTRACT

Introducción: La mayoría de los estudios realizados en prisiones se han centrado en el estudio de la infección por VIH, la adherencia o la TBC. Sin embargo, llama la atención la escasez de estudios sobre las características psicosociales de esta población, como son por ejemplo la morbilidad psíquica, el apoyo social o el consumo de drogas. Objetivos: Describir el estado clínico y psicosocial de los reclusos en tratamiento con antirretrovirales en tres prisiones andaluzas (Córdoba, Granada y Huelva). Material y métodos: Mediante una encuesta transversal, con un cuestionario administrado por entrevistador, se entrevistaron a todos los reclusos en tratamiento con antirretrovirales de los tres centros. Las variables estudiadas fueron: datos sociodemográficos, variables del medio penitenciario, variables sobre la adherencia al tratamiento, variables de salud y variables de apoyo. Resultados: La frecuencia de morbilidad psíquica fue del 42% y el 64,4% refirió tener algún tipo de enfermedad crónica; de éstos, el 12,7% afirmó padecer tuberculosis. El 46,6% afirmaron contar con apoyo social dentro de la prisión, recibiéndolo de otros internos el 45% y de los profesionales de la prisión el 36,6%. El 54,8% fueron considerados no adherentes al tratamiento con antirretrovirales. El 89% consideraba que la comida era mala, y sólo al 29,9% se le facilitaban suplementos de comida. Por último, el 33,8% refería no tener flexibilidad para que le abrieran la celda en caso de olvido del tratamiento. El 31% refería peor salud autopercibida (AU)


Introduction: Most studies conducted in prisons have focused on the study of HIV infection, adherence to treatment or TBC. However, there is a surprisingly small number of studies on the psychosocial characteristics of this population, such as psychic morbidity, social support or drug use. Objective: To describe the clinical and psychosocial status of inmates in treatment with antiretrovirals in three Andalusian prisons (Córdoba, Granada and Huelva). Materials and method: All inmates in treatment with antiretrovirals in the three correctional facilities were interviewed using a heteroadministered questionnaire, with a cross-sectional design. The sociodemographic data, penitentiary, adherence to treatment, health and social support variables were studied. Results: The frequency of psychic morbidity was 42%, and 64,4% of the interviewed sample mentioned having some kind of chronic disease; of these, 12,7% admitted to suffering from tuberculosis. 46,6% stated that they had social support within the prison, receiving it from other inmates in 45% of the cases and 36,6% from professionals of the prison. 54,8% were considered non-adherent to antiretroviral treatment. 89% of the sample considered that the food was of bad quality, and only 29,9% were provided with food supplements. Finally, 33,8% stated that they were not able to have their cells opened if their medication was forgotten. 31% mentioned worse self-perceived health when compared with the previous year (AU)


Subject(s)
Humans , Anti-Retroviral Agents/therapeutic use , HIV Infections/drug therapy , Mental Disorders/epidemiology , Prisoners/statistics & numerical data , Health Status , Social Support , Mental Health Services/organization & administration , Medication Adherence/statistics & numerical data
10.
Hernia ; 6(4): 167-70, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12424594

ABSTRACT

Spigelian hernias are rare defects of the abdominal wall. Our aim is to analyse the bibliography and present a series of 28 patients. A Medline bibliographical study was performed between 1970 and 2000 with analysis of the number of cases, series, ratio of cases to year and type of journal. We also present a personal study and analyse epidemiological, diagnostic, and treatment factors. There are 159 articles, 479 cases, and 19 series of more than five patients published in 85 journals (42.3% medical). Our diagnosis was preoperative in 75%, and programmed surgery was 3.6 times more common than emergency surgery. We found a significant relationship between hospital stay and type of surgery (P < 0.02) and surgical technique used (P < 0.001). We found that spigelian hernias have a multidisciplinary interest; they are given almost equal treatment in medical and surgical journals; preoperative diagnosis can be established in 75% of cases; and the best results are offered by the extraperitoneal laparoscopic approach.


Subject(s)
Hernia, Ventral/surgery , Adolescent , Adult , Aged , Female , Hernia, Ventral/diagnosis , Hernia, Ventral/epidemiology , Humans , Male , Middle Aged , Periodicals as Topic/statistics & numerical data
11.
Surg Endosc ; 16(12): 1806, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12232651

ABSTRACT

Spigelian hernia is an uncommon hernia of the abdominal wall. Diagnosis and treatment are controversial because it is frequently an emergency pathology. We report two patients with preoperative diagnosis and treatment using totally extraperitoneal laparoscopy under regional anesthesia in a day surgery department.


Subject(s)
Ambulatory Surgical Procedures/methods , Hernia, Ventral/surgery , Laparoscopy/methods , Peritoneum/surgery , Adult , Female , Humans , Male , Middle Aged
12.
Cir. Esp. (Ed. impr.) ; 70(6): 291-294, dic. 2001. tab
Article in Es | IBECS | ID: ibc-818

ABSTRACT

Introducción. La reparación laparoscópica de las hernias ventrales cubre el defecto dejando una prótesis intraabdominal. De la adecuada elección del material protésico pueden depender los resultados y complicaciones de esta técnica. Objetivo. Evaluar los resultados de la cirugía laparoscópica en las hernias ventrales con el uso de dos mallas diferentes en posición intraabdominal: Goretex® (politetrafluoroetileno) y Parietex® (poliéster y colágeno).Pacientes y métodos. Análisis retrospectivo de 46 pacientes intervenidos de hernia ventral mediante cirugía laparoscópica. Se estudian las características clínicas de los pacientes (antecedentes médicos y quirúrgicos), el tipo de eventración (clasificación SWR), las complicaciones intra y postoperatorias, la estancia hospitalaria y el seguimiento, en función del tipo de material implantado. Resultados. Todos los pacientes se completaron por cirugía laparoscópica. El análisis estadístico de la morbilidad ha demostrado la existencia de una relación significativa entre el íleo postoperatorio en los defectos múltiples y las mallas de Goretex (p < 0,05) y de los seromas con la malla de Goretex (p < 0,01). El 70 por ciento de las intervenciones realizadas con Parietex se completaron como cirugía mayor ambulatoria y las de Goretex tuvieron una estancia media de 6 días (rango: 2-16). La tasa de recidivas es del 4,3 por ciento (un caso en cada grupo).Conclusiones. La reparación laparoscópica en las hernias ventrales es una alternativa eficaz a la reparación abierta con una baja morbilidad que no se relaciona con el tipo de defecto. Tanto la malla bilaminar Parietex® como la de Goretex® son seguras para su uso intraabdominal (AU)


Subject(s)
Adult , Aged , Female , Male , Middle Aged , Humans , Hernia, Ventral/surgery , Corrective Maintenance , Surgical Mesh , Biocompatible Materials/therapeutic use , Prostheses and Implants , Laparoscopy/methods , Retrospective Studies , Laparoscopy/methods , Laparoscopy , Laparoscopy/classification , Laparoscopy/instrumentation , Laparoscopy/standards , Laparoscopy/trends
13.
Cir. Esp. (Ed. impr.) ; 70(2): 93-97, ago. 2001. ilus
Article in Es | IBECS | ID: ibc-867

ABSTRACT

Objetivo. La invaginación intestinal en el adulto es un proceso potencialmente grave que, por su infrecuencia fuera de la infancia, se diagnostica de forma habitual durante el acto quirúrgico indicado por un síndrome obstructivo mecánico. Presentamos una serie reciente de casos cuyo diagnóstico se obtuvo preoperatoriamente. Pacientes y métodos. Se han analizado los registros de todos los pacientes mayores de 18 años con el diagnóstico postoperatorio de invaginación intestinal tratados en nuestra institución entre 1996 y 2000.Resultados. En 4 años se intervinieron 7 pacientes, con una edad media de 40 años. Todos presentaron datos clínicos de obstrucción intestinal completa o parcial. El diagnóstico preoperatorio etiológico se efectuó en 6 casos, gracias a la realización frecuente de ecografía y tomografía computarizada. Todos los pacientes fueron intervenidos, 3 de forma urgente y 4 con carácter programado. Durante el acto quirúrgico se identificaron las lesiones causantes de la invaginación, 4 localizadas en el íleon terminal (divertículo de Meckel, seudotumor inflamatorio, pólipo fibroide, pólipo adenomatovelloso degenerado), dos en el ciego (ambos adenocarcinoma sobre pólipo) y, en el caso restante, un linfoma doble de yeyuno e íleon. Las intususcepciones fueron ileoileales en 3 casos, ileocólicas en 3 y doble yeyunoileal e ileocólica en el séptimo paciente. Se practicaron 3 hemicolectomías derechas, 2 resecciones ileales, una exéresis de divertículo de Meckel y, finalmente, una doble exéresis (yeyunal e ileocólica) en el caso del linfoma. No existió mortalidad. Conclusiones. La invaginación intestinal en el adulto es una entidad poco frecuente. Los síntomas son los de un cuadro obstructivo mecánico completo o parcial; en estos últimos, la evolución puede ser intermitente o crónica. La ecografía y la tomografía computarizada demuestran ser los métodos de diagnósticos preoperatorios más efectivos. En el adulto, aproximadamente la mitad de los casos se deben a una enfermedad maligna, por lo que la resección es el procedimiento de elección (AU)


Subject(s)
Adult , Female , Male , Middle Aged , Humans , Tomography, Emission-Computed/methods , Intussusception/diagnosis , Intussusception/surgery , Intestinal Obstruction/surgery , Intestinal Obstruction/diagnosis , Intestinal Obstruction , Laparotomy/methods , Granuloma, Plasma Cell/diagnosis , Granuloma, Plasma Cell/etiology , Polyps/diagnosis , Polyps/etiology , Retrospective Studies , Abdomen/surgery , Abdomen , Abdomen/pathology , Abdomen , Meckel Diverticulum/diagnosis , Meckel Diverticulum/etiology
15.
Surg Laparosc Endosc Percutan Tech ; 11(2): 103-6, 2001 Apr.
Article in English | MEDLINE | ID: mdl-11330373

ABSTRACT

Ventral hernia repair is still a difficult problem for surgeons because of the high recurrence rate and possible postoperative complications. Repairs with a prosthesis have reduced the recurrence rate, but the anterior approach still involves high morbidity and a long hospital stay. The purpose of this article was to evaluate the results of laparoscopic surgery on ventral hernias using a new double-layer mesh in an intra-abdominal position. A retrospective analysis was performed of the first 20 patients undergoing laparoscopic surgery for ventral hernia (75% incisional and 25% umbilical) with intra-abdominal prosthetic repair using a double-layer mesh consisting of three-dimensional multifiber polyester on one side and a hydrophilic resorbable nonstick collagen membrane on the other (Parietex composite, Sofradim, Villefranche sur Saone, France). The procedure was done on an outpatient basis in 85% of the cases. There was no morbidity or mortality. During a mean follow-up period of 10 months we found no infections, rejections, fistulas, recurrences, or alterations in bowel function. Laparoscopic repair of ventral hernias is an efficient alternative to open repair, with a low morbidity rate and short hospital stay. The double-layer mesh is safe for intra-abdominal use.


Subject(s)
Hernia, Ventral/surgery , Laparoscopy , Surgical Mesh , Adult , Aged , Ambulatory Surgical Procedures , Equipment Design , Female , Humans , Male , Middle Aged , Retrospective Studies
16.
Cir. Esp. (Ed. impr.) ; 69(4): 371-374, abr. 2001.
Article in Es | IBECS | ID: ibc-1064

ABSTRACT

Introducción. La reparación de las hernias ventrales todavía supone un difícil problema para el cirujano general por su alto índice de recidivas y de complicaciones postoperatorias. Las reparaciones con prótesis han disminuido la tasa de recidivas, pero la vía anterior todavía supone una considerable morbilidad y una elevada estancia hospitalaria. Objetivo. Evaluar los resultados de la cirugía laparoscópica en las hernias ventrales y la tolerancia de una nueva malla en posición intraabdominal. Pacientes y métodos. Análisis retrospectivo de los primeros 20 pacientes que se han intervenido por hernia ventral (75 por ciento incisionales y 25 por cientoumbilicales) mediante cirugía laparoscópica con reparación protésica intraabdominal con una malla bilaminar: por un lado, poliéster multifibra tridimensional y, por otro lado, una membrana antiadherente hidrofílica y reabsorbible de colágeno. Resultados. Todos los pacientes fueron intervenidos sin morbimortalidad. El 85 por ciento de las intervenciones se realizaron como cirugía sin ingreso. Durante el seguimiento medio de 10 meses no se han encontrado infecciones, rechazos, fístulas, recidivas ni alteraciones del tránsito intestinal. Conclusiones. La reparación laparoscópica en las hernias ventrales es una alternativa eficaz a la reparación abierta y la malla bilaminar Parietex® es segura para su uso intraabdominal (AU)


Subject(s)
Adult , Female , Male , Middle Aged , Humans , Hernia, Ventral/surgery , Laparoscopy , Postoperative Complications , Prosthesis Implantation , Retrospective Studies
17.
Am J Forensic Med Pathol ; 21(1): 21-31, 2000 Mar.
Article in English | MEDLINE | ID: mdl-10739222

ABSTRACT

The diagnosis of the vital origin of wounds in many cases remains an unsolved problem for the forensic pathologist. Practical experience enables the expert to diagnose the vital or postmortem origin of wounds on the basis of macroscopic examination. In some cases, optic microscopy is used to confirm the diagnosis. In many other cases, additional more sensitive and specific markers of vitality are required. In the past 50 years, comprehensive research on this topic has resulted in a better understanding of the acute inflammatory reaction. The development and application of sensitive and specific markers through research in the areas of histochemistry, enzymology, and biochemistry has provided a partial solution to the problems involved in wound vitality diagnosis. A review of this challenging area of forensic pathology, including an explanation of these methods and markers, is presented in this paper.


Subject(s)
Forensic Medicine , Wound Healing/physiology , Wounds and Injuries/etiology , Wounds and Injuries/physiopathology , Biomarkers , Forensic Medicine/methods , Humans
18.
Fertil Steril ; 67(6): 1159-61, 1997 Jun.
Article in English | MEDLINE | ID: mdl-9176461

ABSTRACT

OBJECTIVE: To report a case of heteropaternal superfecundation. DESIGN: Case report. SETTING: University paternity laboratory. PATIENT(S): Father, mother, and a set of twins. INTERVENTION(S): Blood typing conventional markers, as well as polymerase chain reaction loci and restriction fragment length polymorphism loci of DNA. MAIN OUTCOME MEASURE(S): Heteropaternal superfecundation was demonstrated after paternity investigation. RESULT(S): The probability of paternity for twin 1 was 99.9999998%, whereas that for twin 2 was excluded on the basis of the following tests: Fy, Pi, human leukocyte antigen (HLA)-DQA1, D1S80, D17S5, HBGG, D5S110, D2S44, and D10S28. CONCLUSION(S): Dizygous twins can have different biologic fathers, as demonstrated in this case. According to published data, the frequency of twins with different fathers is probably underestimated, at least in small selected populations such as those of paternity suits.


Subject(s)
DNA/analysis , Genetic Markers , Paternity , Twins, Dizygotic , Blood Grouping and Crossmatching , Female , HLA-DQ Antigens/genetics , HLA-DQ alpha-Chains , Humans , Infant, Newborn , Male , Polymerase Chain Reaction , Polymorphism, Restriction Fragment Length , Probability
19.
Forensic Sci Int ; 82(2): 153-63, 1996 Sep 30.
Article in English | MEDLINE | ID: mdl-8885374

ABSTRACT

We compared the post mortem diagnostic value of gamma-glutamyltransferase (GGT), carbohydrate-deficient transferrin (CDT), alcoholic liver disease (ALD), blood alcohol concentration (BAC), the presence of multiple bruises and poor hygiene of the feet as markers of chronic alcoholism (heavy continuous drinking) in 32 alcoholics with 32 age-sex matched controls drawn from a forensic autopsy population. Alcoholics and controls were selected on the basis of positive and negative medical history but controls were excluded if BAC exceeded 70 mg%. Femoral venous blood, urine and vitreous humour alcohol concentrations were determined by headspace gas chromatography (GC). BAC was positive in 19 alcoholics (mean 234 mg%, range 2-570 mg%) and six controls (mean 32 mg%, range 2-52 mg%). Serum GGT was measured by a kinetic photometric method, and CDT by both isoelectric focusing/laser densitometry and by a commercial radioimmunoassay kit (CDTect). Features of alcoholic liver disease were graded histologically using two weighted scoring systems. Eleven alcoholics tested positive for GGT, CDTq and ALD, nine were positive for two tests, five for one test and three were negative for all three tests. No controls were positive for all three tests but six were positive for two tests and nine for only one test; 17 were negative for all three tests. Using the normal clinical cut-off values GGT, CDTq and CDTect gave poor specificity which was improved at moderate cost to sensitivity by raising cut off values for each test. Comparison of receiver operating characteristic curves, likelihood ratios and post-test odds showed CDT to be the best individual test, followed by ALD and GGT. Quantitation of CDT by IEF/laser densitometry performed slightly better than MAEC/RIA by CDTect. CDT shows considerable promise as a post mortem marker of chronic alcoholism.


Subject(s)
Alcoholism/diagnosis , Postmortem Changes , Alcoholism/pathology , Autopsy , Biomarkers/blood , Chromatography, Gas , Foot/pathology , Humans , Liver/pathology , Liver Diseases, Alcoholic/pathology , ROC Curve , Sensitivity and Specificity , Transferrin/analogs & derivatives , Transferrin/analysis , gamma-Glutamyltransferase/blood
20.
Forensic Sci Int ; 76(2): 141-9, 1995 Dec 18.
Article in English | MEDLINE | ID: mdl-8566914

ABSTRACT

The potential of skin measurements of D-dimer (DD), a specific derivative of crosslinked fibrin, for the diagnosis of the vital origin of wounds was investigated in 67 human vital skin wounds and homolateral control pieces of skin from 53 autopsies performed at the Institute of Legal Medicine of Coimbra (Portugal) during 1992. Our results demonstrate that DD levels for the incised vital skin wounds (n = 50) were much higher on average than their controls (P < 0.01) which were actually incised injuries produced postmortem at the autopsy. We did not find any statistical difference in average DD levels among the remaining injuries (seven abrasions and ten contusions) in comparison to their respective controls. DD may be used, with certain limitations, as a marker of the vitality of incised wounds. The authors believe this is the first time this marker has been applied in forensic pathology. It is an example of an easy and quick application technique, with the added advantage of low cost.


Subject(s)
Contusions/pathology , Fibrin Fibrinogen Degradation Products/analysis , Postmortem Changes , Wounds, Penetrating/pathology , Autopsy , Biomarkers/analysis , Fibrinogen/analysis , Humans , Reproducibility of Results , Time Factors
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