ABSTRACT
Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there is an urgent need to develop novel therapies. In this study, we investigated the antitumor activity of MS-5, a naphthalene derivative, on BxPC-3, a human pancreatic cancer cell line. We observed that MS-5 was cytotoxic to BxPC-3 cells, as well as inhibited the growth of cells in a concentration- and time- dependent manner. Flow cytometry analysis revealed that the percentage of annexin V-positive cells increased after MS-5 treatment. We also observed cleavage of caspases and poly (ADP-ribose) polymerase, and downregulation of Bcl-xL protein. Flow cytometry analysis of intracellular levels of reactive oxygen species (ROS) and mitochondrial superoxide suggested that MS-5 induced the generation of mitochondrial superoxide while lowering the overall intracellular ROS levels. Thus, MS-5 may be potential candidate for pancreatic cancer treatment.
ABSTRACT
This paper presents the Plug-Load Appliance Identification Dataset (PLAID), a labelled dataset containing records of the electrical voltage and current of domestic electrical appliances obtained at a high sampling frequency (30 kHz). The dataset contains 1876 records of individually-metered appliances from 17 different appliance types (e.g., refrigerators, microwave ovens, etc.) comprising 330 different makes and models, and collected at 65 different locations in Pittsburgh, Pennsylvania (USA). Additionally, PLAID contains 1314 records of the combined operation of 13 of these appliance types (i.e., measurements obtained when multiple appliances were active simultaneously). Identifying electrical appliances based on electrical measurements is of importance in demand-side management applications for the electrical power grid including automated load control, load scheduling and non-intrusive load monitoring. This paper provides a systematic description of the measurement setup and dataset so that it can be used to develop and benchmark new methods in these and other applications, and so that extensions to it can be developed and incorporated in a consistent manner.
