Crystal structure analysis of [5-(4-meth-oxy-phen-yl)-2-methyl-2H-1,2,3-triazol-4-yl](thio-phen-2-yl)methanone.

The title compound, C15H13N3O2S, crystallizes in the monoclinic space group P21/n and its mol-ecular conformation is stabilized via intra-molecular C-H⋯O and C-H⋯N contacts. The supra-molecular structure is mainly governed by C-H⋯N hydrogen-bonded centrosymmetric dimers, C-H⋯O and C-H⋯S hydrogen bonds and S⋯π and π-π stacking inter-actions which, together, lead to the formation of a layered crystal packing. The inter-molecular inter-actions were further evaluated through the mol-ecular electrostatic potential map and Hirshfeld fingerprint analysis.

Mixed-Phase 2D-MoS2 as an Effective Photocatalyst for Selective Aerobic Oxidative Coupling of Amines under Visible-Light Irradiation.

Metal-semiconductor heterojunctions play a vital role in photocatalysis, yet their preparation can be exceedingly difficult. The heterojunction helps not only to separate the charges and inhibit recombination processes but also to transfer the photogenerated electron/hole to the reacting molecule. Here, we demonstrate 1T (metallic)-2H (semiconducting) phase boundaries intrinsic to individual sheets of chemically exfoliated 2D-MoS2 can serve as heterojunctions for enhanced photocatalysis in comparison to only semiconducting phase. Due to the abundance of heterojunctions in these multiphasic materials, chemically exfoliated 2D-MoS2 provides improved stability and transfer of photogenerated charges to the reactants, giving better yield. We demonstrate that this easy to synthesize material is an effective photocatalyst for the aerobic oxidative coupling of amines to imines under visible light irradiation. Given its broad applications, we believe mixed phase 2D-MoS2 can be of interest to several industrial synthetic applications related to semiconductor-based photocatalysis. As an added advantage, this heterogeneous photocatalyst can be recycled for several times up to five cycles without any significant loss in the activity.

Graphene Oxide as a Carbocatalyst for a Diels-Alder Reaction in an Aqueous Medium.

The Diels-Alder (DA) reaction, a [4+2] cycloaddition reaction, is highly important in synthetic organic chemistry and is frequently used in the synthesis of natural products containing six-membered rings. Herein, we report an efficient protocol for the DA reaction between 9-hydroxymethylanthracene and N-substituted maleimides using two-dimensional graphene oxide (GO) as a heterogeneous carbocatalyst in an aqueous medium at room temperature. High yields, a wide substrate scope, low temperature, excellent functional group tolerance, atom economy, and water as a green solvent are noteworthy features of this protocol. The heterogeneous GO catalyst can be easily recovered and used multiple times without any significant loss in catalytic activity.

Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives.

4-Thiazolidinone derivatives were synthesized using T3P®-DMSO media as a cyclodehydrating agent. All the molecules were tested for their cytotoxicity against leukemic cell lines. The compound 3-(4-bromophenyl)-2-(4-(dimethylamino)phenyl)thiazolidin-4-one (4e) with electron donating substituent at para position of phenyl ring displayed considerable cytotoxicity against Reh and Nalm6 cells with an IC50 value of 11.9 and 13.5 µM, respectively. Furthermore, the compound 4e tested for tumor regression studies induced by EAC in Swiss albino mouse. Both in vitro and in vivo results suggested significant antiproliferative activity of compound 4e in Reh cells and mouse tumor tissue treated with compound 4e showed multifocal areas of necrosis and numerous number of apoptotic cells.