ABSTRACT
Nasal spray products containing desmopressin acetate (DDAVP) were tested in vitro to evaluate the effect of the contained preservatives on drug permeation across rabbit nasal mucosa. Experiments were performed using Franz-type diffusion cells with rabbit nasal mucosa as model barrier. Transport profiles obtained in comparison with a preservative-free solution evidenced that in the presence of preservatives DDAVP permeation in vitro always increased (p<0.05), although at different extents (chlorobutanolSubject(s)
Deamino Arginine Vasopressin/administration & dosage
, Deamino Arginine Vasopressin/pharmacokinetics
, Nasal Mucosa/drug effects
, Nasal Mucosa/metabolism
, Preservatives, Pharmaceutical/pharmacology
, Sorbic Acid/pharmacology
, Adjuvants, Pharmaceutic/pharmacology
, Administration, Intranasal
, Animals
, Benzalkonium Compounds/chemistry
, Chlorobutanol/chemistry
, Diffusion/drug effects
, In Vitro Techniques
, Permeability/drug effects
, Rabbits
, Therapeutic Equivalency
