ABSTRACT
Eigtheen patients affected by metastatic renal cell carcinoma, 16 which were assesable, were treated with 1 g/m2 of Gemcitabine (GCB) on days 1, 8 and 15 of a 28-day treatment cycle up to a maximun of ten cycles. All patients in neoplastic progression were treated with chemo- and immunotherapy (5 FU, IL-2, IFN alpha d 13-cis-retinoic acid.) Out of the 16 assessable patients, 5/16 (31%) showed overall response (ICR, 4 PR), 5 (31%) stable disease (SD) and 6 (38%) progression of disease (PD). Toxicity was limited to WHO grades I only, primarily hematological.
Subject(s)
Antimetabolites, Antineoplastic/therapeutic use , Carcinoma, Renal Cell/drug therapy , Deoxycytidine/analogs & derivatives , Deoxycytidine/therapeutic use , Kidney Neoplasms/drug therapy , Adult , Aged , Antimetabolites, Antineoplastic/adverse effects , Carcinoma, Renal Cell/secondary , Deoxycytidine/adverse effects , Disease Progression , Feasibility Studies , Female , Humans , Male , Middle Aged , GemcitabineABSTRACT
Mammography remains the most important breast exam; mammography, know to be highly sensitive in detecting microcalcifications. Ultrasound is not suitable for screening, but it allows enough resolution to discriminate the very subtle differences of acoustic impedance among the breast tissue. The indications for MRI of the breast is far established may be defined as follows: 1) patients with silicone implants with or without mastectomy; 2) patients whose breast are difficult to evaluate by combined mammography and ultrasonography, who have: a) had breast conservation therapy, b) axillary lymph-node metastasis from an unknown primary tumor; c) postoperative scarring; d) proven carcinoma of one breast, MRI being performed to exclude multifocality. The authors recommend caution in the use of breast MRI in the assessment and management of suspected recurrent carcinoma.
Subject(s)
Breast Diseases/diagnosis , Breast/pathology , Magnetic Resonance Imaging , Mammography , Breast Diseases/diagnostic imaging , Breast Diseases/pathology , Breast Neoplasms/diagnosis , Breast Neoplasms/therapy , Combined Modality Therapy , Female , Humans , Image Interpretation, Computer-Assisted , Neoplasm Staging , UltrasonographyABSTRACT
Spiral Computed Tomography (CT) has rapidly gained acceptance as the preferred CT technique for routine liver evaluation because it provides image acquisition at peak enhancement of the liver parenchyma during single breath hold. In this study, we evaluated a wide range of non cystic liver lesions with triphasic spiral CT technique, that allows imaging of the entire liver in arterial, portal and equilibrium phases. In particularly we focused on hemangioma, adenoma, focal nodular hyperplasia, hepatocarcinoma and metastases.
Subject(s)
Liver Diseases/diagnostic imaging , Liver Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Diagnosis, Differential , Humans , Liver Diseases/pathology , Liver Neoplasms/pathology , Tomography, X-Ray Computed/methodsABSTRACT
Twenty patients (pts) with metastatic breast cancer with disease progression, previously treated with chemotherapy and tamoxifen, were administered oral letrozole (2.5 mg/day) therapy. Fifteen of the patients were postmenopausal and 5 were premenopausal. Ten were estrogen receptor (ER)-positive, 7 were unknown and 3 were ER-negative. All the patients were assessed after 6 months (mo) of chemotherapy. Nine pts (45%) presented a partial response (PR), five (25%) had a stable disease (SD) and six (30%) had a progressive disease (PD). In the pts with PD, six out of 15 (33%) obtained a PR while undergoing tamoxifen therapy. The treatment caused no significant toxicity.
