Subject(s)
Immunoglobulin A, Secretory/immunology , Immunoglobulin A/immunology , Immunoglobulin D/immunology , Immunoglobulin J-Chains/immunology , Humans , Immunoglobulin A/biosynthesis , Immunoglobulin D/biosynthesis , Immunoglobulin G/biosynthesis , Immunoglobulin M/biosynthesis , Intestinal Mucosa/immunology , Jejunum/immunology , Lacrimal Apparatus/immunology , Parotid Gland/immunology , Stomach/immunologySubject(s)
Eye Foreign Bodies , Ultrasonography , Aluminum , Autopsy , Copper , Eye/pathology , Glass , Humans , Iron , Orbit/pathology , Plastics , Sclera/pathology , Vitreous Body/pathology , WoodSubject(s)
Collagen Diseases/chemically induced , Connective Tissue , Cystinuria/drug therapy , Infant, Newborn, Diseases/chemically induced , Penicillamine/adverse effects , Pregnancy Complications/drug therapy , Collagen Diseases/congenital , Collagen Diseases/pathology , Connective Tissue/pathology , Elasticity , Female , Humans , Infant, Newborn , Joint Diseases/chemically induced , Joint Diseases/congenital , Pregnancy , Skin Diseases/chemically induced , Skin Diseases/pathology , Wound HealingSubject(s)
gamma-Globulins/isolation & purification , Adolescent , Adult , Animals , Chromatography, DEAE-Cellulose , Chromatography, Gel , Colostrum , Diffusion , Electrophoresis , Epitopes , Female , Gastric Juice , Humans , Immune Sera , Immunoelectrophoresis , Immunoglobulins/blood , Immunoglobulins/isolation & purification , Male , Models, Structural , Nasal Mucosa/metabolism , Parotid Gland/metabolism , Peptides , Polymers , Rabbits , Saliva/analysis , Saliva/immunology , Submandibular Gland/metabolism , Sweat , VirusesABSTRACT
Oral bacteria become coated with immunoglobulin A in human saliva in vivo. This may indicate that the salivary immunoglobulin A possesses antibacterial activity. Some of the immunoglobulin-coated cocci grow in extremely long chains and exhibit synchronous cell division. The long chain phenomenon may result from growth in the presence of salivary antibody specific to antigenic determinants of the bacterial cell walls.
Subject(s)
Mouth/microbiology , Saliva/immunology , gamma-Globulins , Adsorption , Adult , Antibodies, Anti-Idiotypic/analysis , Bacteria/growth & development , Bacteria/immunology , Cell Division , Child , Fluorescent Antibody Technique , Humans , Immune Sera/analysis , Immunoelectrophoresis , Microscopy, Fluorescence , Saliva/microbiologyABSTRACT
Local synthesis seems to be decisive for the selective secretion of 19S immunoglobulin M into parotid secretions. The "transport piece" is apparently not involved in the secretion of immunoglobulin M, for there is no association between the two components. The possible significance of the normal association of transport piece with secreted immunoglobulin A remains to be clarified.