Subject(s)
Meningioma , Paracentesis , Tympanic Membrane , Ear Neoplasms/complications , Ear Neoplasms/diagnosis , Ear Neoplasms/pathology , Ear Neoplasms/therapy , Female , Foramen Magnum/diagnostic imaging , Foramen Magnum/pathology , Hearing Loss/etiology , Humans , Jugular Veins/diagnostic imaging , Jugular Veins/pathology , Magnetic Resonance Imaging , Meningeal Neoplasms/diagnosis , Meningeal Neoplasms/pathology , Meningeal Neoplasms/therapy , Meningioma/diagnosis , Meningioma/pathology , Meningioma/therapy , Tympanic Membrane/diagnostic imaging , Tympanic Membrane/pathologySubject(s)
Cysts/diagnostic imaging , Magnetic Resonance Imaging , Neurilemmoma/diagnostic imaging , Palatal Neoplasms/diagnostic imaging , Skull Base Neoplasms/diagnostic imaging , Adult , Cysts/pathology , Cysts/surgery , Female , Humans , Magnetic Resonance Angiography , Margins of Excision , Neoplasm Invasiveness , Neurilemmoma/blood supply , Neurilemmoma/pathology , Neurilemmoma/surgery , Palatal Neoplasms/blood supply , Palatal Neoplasms/pathology , Palatal Neoplasms/surgery , Skull Base Neoplasms/blood supply , Skull Base Neoplasms/pathology , Skull Base Neoplasms/surgerySubject(s)
Hyperpigmentation/diagnostic imaging , Hyperpigmentation/etiology , Nasopharyngeal Neoplasms/diagnostic imaging , Plasmacytoma/diagnostic imaging , Plasmacytoma/pathology , Tonsillar Neoplasms/diagnostic imaging , Biopsy , Female , Fluorodeoxyglucose F18 , Follow-Up Studies , Humans , Hyperpigmentation/pathology , Middle Aged , Nasopharyngeal Neoplasms/pathology , Nasopharyngeal Neoplasms/radiotherapy , Nasopharynx/diagnostic imaging , Nasopharynx/pathology , Palatine Tonsil/diagnostic imaging , Palatine Tonsil/pathology , Plasmacytoma/radiotherapy , Positron Emission Tomography Computed Tomography , Tonsillar Neoplasms/pathology , Tonsillar Neoplasms/radiotherapyABSTRACT
INTRODUCTION: Malignant and benign cells differ according to their elasticity. An atomic force microscope is a useful tool for measuring these mechanical cell properties. If cells of different dignity show different resonance behavior, due to their different elasticity, a selective ablation of specific tissue types by ultrasound would be possible. The goal is a highly selective ablation of tumor tissue without damaging healthy tissue. MATERIALS AND METHODS: We performed elasticity measurements of tumor cells (UD-01 cell line) with an atomic force microscope. In a further step, an ultrasound applicator has been positioned and the morphological changes of the cells during the treatment were documented. RESULTS: Different elasticities on the squamous cells were measured, depending on the location. Below a defined maximum amplitude the morphological cell changes were caused solely by ultrasonic excitation. SUMMARY: The atomic force microscope is suitable for the determination of the individual cell elasticity. The data collected could be the basis for treatment modalities that lead to a very selective damage for malignant cells.