ABSTRACT
Under examination were 60 patients with local forms of soft tissue sarcomas of various histological structure. By means of skin delayed hypersensitivity test for dinitrochlorobenzene (DNCB) and tuberculin as well as cell immunity reaction in vitro the immune response was shown to be of value in estimating the prognosis of the disease. The dynamics of immune reactions 2-3 months following the operation proved to be of greatest prognostic value. Among the employed immunological tests the skin test for DNCB and the reaction of spontaneous rosette-forming provided the most comprehensive information as to the control over the clinical course of malignant lesion.
Subject(s)
Antigen-Antibody Reactions , Sarcoma/immunology , Soft Tissue Neoplasms/immunology , Adolescent , Adult , Aged , Cell Migration Inhibition , Humans , Immunity, Cellular , Lymphocyte Activation , Middle Aged , Prognosis , Rosette Formation , Sarcoma/surgery , Skin Tests , Soft Tissue Neoplasms/surgery , Time FactorsABSTRACT
The authors report the results of studying the cell immunity by skin delayed hypersensitivity response to DNCB and tuberculin as well as the reactions of spontaneous rosette-formation, blasttransformation to PHA, inhibition of leucocyte migration in 88 patients with soft tissue sarcomas, in 12 patients with desmoids, the control group comprised 19 patients with benign soft tissue tumors. The study has indicated a reliably impaired cell immunity in patients with sarcomas.