[Endogenic vasomotor function and smooth muscle insufficiency in the vascular microcirculation]. / Makhanizm éndogennoi vazomotoriki i gladkomyshechnoi nedostatochnosti mikrotsirkuliatornogo rusla.

The paper outlines the previously unknown smooth muscle insufficiency in terms of its etiology, pathogenesis, diagnosis and treatment. It has been shown that drug administration leads to smooth muscle insufficiency which is eliminated by serotonin both in vitro and in vivo. The clinical manifestations of smooth muscle (SM) insufficiency are eliminated by serotonin, irrespective of whether it has been caused by the use of drugs or impaired smooth muscle innervation. The mechanism of vascular rhythmic oscillations in the microcirculatory bed, the so-called endogenous vasomotility (EV) has been decoded. The mechanism of EV regulation is due to the fact that platelets constantly (continuously) adsorb serotonin from the enterochromaffin cells of the gastrointestinal tract and constantly (continuously) release it into the microcirculatory bed, thereby providing the continuum of entry of the stimulant to the SM fibers which are able to contract at this time. The summation of these contractions of smooth muscle contractions in the microcirculatory bed maintains their vascular tone and yields the pattern of EV. The paper also describes the earlier unknown properties of hemoglobin and myoglobin to cause smooth muscle spasm and to accelerate platelet destruction. A correlation between the EV and vascular platelet hemostasis is described in terms of these properties. The continuous mechanism of EV is impaired and it transforms to intermittent (final) vascular platelet hemostasis.

[Role of radiologic diagnosis in the evaluation of morphologic and functional changes in muscular veins of the leg in the pathogenesis of varicose disease]. / Rol rentgenomorfologicheskikh i funktsionalnykh izmenenii myshechnykh ven goleni v patogeneze varikoznoi bolezni.

A total of 100 patients with varicosis of lower limb veins were investigated with the help of distal ascending phlebography in horizontal, vertical and tilted positions. Considerable differences in x-ray images of musculi gastrocnemius and soleus (MGS) were noted. Four main types of MGS (conic, spindle-form, U-form, and balloon-like) were singled out. Correlation between muscular vein sizes and stages of varicosis was revealed. An important role of the pathology of muscular veins in dysfunction of the leg pump as one of the factors of pathogenesis of lower limb varicosis was confirmed.

[Reconstructive surgery of valvular incompetence of deep veins in patients with varicosity of the lower limbs]. / Rekonstruktivnaia khirurgiia klapannoi nedostatochnosti glubokikh ven u bol'nykh varikoznoi bolezn'iu nizhnikh konechnostei.

The individual indications for applying four methods for valve correction in 241 patients with valvular incompetence of the deep veins were determined on the basis of a developed four-stage organization-diagnostic complex. The methods were as follows: correction with a lavsan spiral (70 operations), suturing with paravasal structures (59), three-ligature method (142), and an original method with shortening of the cusps without opening the vein (30 operations). Study of the late results in follow-up periods of 12 months to 7 years showed the latter method to be most effective (88.2%).

[Surgical correction of valvular insufficiency of deep varicose veins of the lower extremities]. / Khirurgicheskaia korrektsiia nedostatochnosti klapanov glubokikh ven nizhnikh konechnostei pri varikoznoi bolezni.

A scheme for preoperative examination of the patients with varicose disease is presented. Incompetence of the deep venous valves was revealed in 74.1% of the patients with varicose disease and in 76.5%--with its postoperative recurrences. Correction of ++phlebo-hemodynamics was accomplished by means of a carcass spiral, fascial paravasal structures and suggested by the authors method of placing the three corrective ligatures, which has proved to be the most effective. One hundred and forty two operations on the deep veins were performed in 102 patients. In observation for up to 4 years, in 94.7% the excellent and good results were noted.

[Evaluation of changes in the deep veins of the lower limbs in varices]. / Otsenka izmenenii glubokikh ven nizhnykh konechnostei pri varikoznoi bolezni.

The authors analysed the results of studying disorders of the deep veins of the lower limbs in 106 patients with varicosity, who were examined by means of distal ascending and retrograde femoral and popliteal phlebography. Ectasia of the deep veins was revealed in 97 (91.5%) and valvular incompetence--in 89 (84%) patients. The authors elaborated a phlebographic evaluation of the degree of ectasia and a classification of valvular incompetence according to the manifestation of the retrograde blood flow in them, which is necessary for a differentiated approach to the surgical correction of these disorders.

[Effect of functional disorders of deep veins of the lower extremities on the clinical course of varicose veins]. / Vliianie narushenii funktsional'nogo sostoianiia glubokikh ven nizhnikh konechnostei na klinicheskoe techneie varikoznoi bolezni.

Results of the complex clinical and phlebographic examination of 106 patients with the varicose disease were studied. It was established that the degree of alterations of the venous outflow was dependent on the spread of ectasia of profound veins, while the clinical form of ectasia of the profound veins--on the state of the valve system.

[Musculo-venous "pump" of the foot in patients with varicose disease]. / Myshechno-venoznaia "pompa" stopy u bol'nykh varikoznoi bolezn'iu.

Methods of rheovasography, phlebotonometry and phlebography of the foot were used for studying the musculo-venous "pump" of the foot in 75 patients with varicose disease. It was found that the latter is responsible for up to 30% of the venous return of blood from lower extremities in walking. Dysfunction of the foot musculo-venous "pump" makes its appearance in patients with varicose disease at the decompensation stage with complicated course of the disease. The preoperative examination of the patients must establish the functional state of this structure, the correction of the alterations found being included in the operation volume.

[Surgical correction of disorders of the musculo-venous pump of the foot in patients with varicose veins]. / Operativnaia korrektsiia narushenii myshechno-venoznoi pompy stopy u bol'nykh varikoznoi bolezn'iu.

An analysis of complex examinations and operative treatment of 106 patients with varicose disease having a varicose dilatation of the foot veins was performed. Technical methods of the operative correction of the alterations of foot hemodynamics described in the article are able to liquidate clinical manifestations of the submalleolar venous insufficiency and thus to obtain better functional results in treatment of patients with varicose disease.

[Hypokalemic alkalosis in patients with pyloroduodenal stenosis]. / Gipokaliemicheskii alkaloz u bol'nykh s piloroduodenal'nym stenozom.

The work presents an analysis of results of examinations and treatment of 56 patients with Darrow hypokalemic alkalosis resulting from stenosis of the pylorus. In 45 of them the stenosis was caused by ulcer disease of the stomach and duodenum. The timely diagnosis, admission to the hospital and adequate therapy in 53 patients facilitated successful surgical interventions. In 3 patients the therapy was ineffective.