1.
Neurology
; 67(11): 2048-9, 2006 Dec 12.
Article
in English
| MEDLINE
| ID: mdl-17159118
ABSTRACT
Seizures during thrombolytic therapy for ischemic stroke have not previously been described as a favorable prognostic sign. We report three patients with severe stroke (NIH Stroke Scale [NIHSS] score 15 to 20) who experienced a seizure during tissue plasminogen activator (tPA) infusion. While initially raising alarm about possible hemorrhage, the seizures heralded dramatic recovery (an immediate 15-point NIHSS score improvement after tPA; NIHSS score 0 or 1 at 24 hours). We propose that the seizures during thrombolysis may indicate cortical reperfusion and/or hyperperfusion due to early recanalization of an acutely occluded intracranial artery.
Subject(s)
Recovery of Function , Seizures/physiopathology , Stroke/drug therapy , Stroke/physiopathology , Thrombolytic Therapy/adverse effects , Adult , Aged, 80 and over , Female , Humans , Male , Middle Aged , Recovery of Function/physiology , Seizures/chemically induced , Tissue Plasminogen Activator/adverse effects
2.
Cephalalgia
; 25(7): 550-3, 2005 Jul.
Article
in English
| MEDLINE
| ID: mdl-15955045