1.
Neuroreport
; 10(5): 913-8, 1999 Apr 06.
Article
in English
| MEDLINE
| ID: mdl-10321459
ABSTRACT
Using in situ hybridization and immunochemical methods, we have observed an increase in the expression of SNS/PN3 sodium channel mRNA and protein in cerebellar Purkinje cells of the taiep rat. These changes are present in taiep rats at 12 months of age, following loss of myelin, but not at one month, prior to loss of myelin. Increased SNS/PN3 expression is not associated with aging per se, because it was not observed in control rats at 12 months of age. These results suggest that altered sodium channel expression in Purkinje cells may contribute to the ataxia that occurs in taiep rats.
Subject(s)
Demyelinating Diseases/metabolism , Purkinje Cells/metabolism , Sodium Channels/metabolism , Aging/metabolism , Animals , Demyelinating Diseases/genetics , Immunohistochemistry , In Situ Hybridization , NAV1.8 Voltage-Gated Sodium Channel , Rats , Rats, Mutant Strains/genetics , Rats, Mutant Strains/metabolism , Rats, Sprague-Dawley , Reference Values
2.
Nat Neurosci
; 1(8): 653-5, 1998 Dec.
Article
in English
| MEDLINE
| ID: mdl-10196578