[The effect of the activation of lipid peroxidation on the structure of extraembryonic organs and the liver in rats at different periods of ontogeny]. / Vliianie aktivatsii perekisnogo okisleniia lipidov na strukturu vnezarodyshevykh organov i pecheni krys v razlichnye periody ontogeneza.

The influence of activation of lipid peroxidation (LP) on morphofunctional organization of extraembryonic compounds and liver on different stages of rat's ontogenesis was studied. It is found that LP-activation (paraquat injection) in late pregnancy leads to extensive vacuolization of trophoblastic and yolk sac cells. In the embryonic liver, the number of hemopoietic cells decreases. During the first days after LP activation in the liver of adult animals, enlargement of granular endoplasmic reticulum elements and their degranulation were revealed. In the liver cells of the offsprings, administered paraquat prenatally, signs of bile formation activation were detected.

[Morphological evidence of the possible role of cytochrome P-450 in the development of an autoimmune process in the liver]. / Morfologicheskie svidetel'stva vozmozhnoi roli tsitokhroma P-450 v razvitii autoimmunnogo protsessa v pecheni.

Morphological alterations in rat's liver during lipid peroxidation induction by paraqat were studied. Infiltration of liver by lymphocytes, macrophages and plasma cells was studied. On ultrastructure level profound extension of rough reticulum cistern and destruction of mitochondrial cristae were revealed by immunohistochemical methods. Cytochrom P-450 was localized on the fibrin fibers.