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Ergoline derivatives with oral, prolonged, alpha-adrenolytic activity.
Bernardi, L; Bosisio, G; Croci, M; Elli, C; Temperilli, A; Arcari, G; Falconi, G; Glaesser, A.
Farmaco Sci ; 33(2): 118-25, 1978 Feb.
Article in English | MEDLINE | ID: mdl-204511

ABSTRACT

The alpha-adrenolytic activity of 1-methyl-10-methoxydihydrolysergol 2-(3,5-dimethyl)pyrrolcarboxylate (XV, formula II) is, both in vitro and parenterally, quite similar to that of dihydroergotamine. By oral route the new compound is more active, and longer lasting than dihydroergotamine.


Subject(s)
Ergolines/chemical synthesis , Nicergoline/chemical synthesis , Sympatholytics/chemical synthesis , Administration, Oral , Animals , Delayed-Action Preparations , Dihydroergotamine/pharmacology , Guinea Pigs , Injections, Intravenous , Male , Nicergoline/administration & dosage , Nicergoline/analogs & derivatives , Receptors, Adrenergic, alpha/drug effects , Structure-Activity Relationship
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