ABSTRACT
OBJECTIVES: Previous studies showed that motor motions play an important role in determining apical extrusion of debris. Therefore a new clinical motion (MIMERACI) has been proposed. The basic idea is to progress slowly (1mm advancement), and after each 1mm, to remove the instrument from the canal, clean flutes and irrigate. The aim of the study was to prove whether the clinical use of MIMERACI technique would influence or not postoperative pain. MATERIALS AND METHODS: 100 teeth requesting endodontic treatment were selected for the study and divided into two similar groups based on anatomy, pre-operative symptoms and vitality, presence or absence of periapical lesion. All teeth were shaped, cleaned and obturated by the same operator, using the same NiTi instruments. The only difference between the two groups was the instrumentation technique: tradional (group A) vs MIMERACI (group B). Assessment of postoperative pain was performed 3 days after treatment. Presence, absence and degree of pain were recorded with a visual analogue scale (VAS), validated in previous studies. Collected data statistically analyzed using one-way ANOVA post hoc Tukey test. RESULTS: For VAS pain scores MIMERACI technique showed significantly better results than group A (p=0,031). Overall, both incidence and intensity of symptoms were significantly lower. Flare ups occurred in 3 patients, but none treated with the MIMERACI Technique. CONCLUSIONS: Since extruded debris can elicit more postoperative pain, results obtained by using MIMERACI technique are probably due to many factors: better mechanical removal and less production of debris and more efficient irrigation during instrumentation.
Subject(s)
Pain, Postoperative/epidemiology , Root Canal Preparation/methods , Adolescent , Adult , Aged , Humans , Incidence , Middle Aged , Nickel , Titanium , Tooth Apex , Young AdultABSTRACT
TRAF-3 gene products are signaling adaptor molecules required for lymphocytes to mediate T-dependent antibody responses in vivo. Previous work identified 8 splice-variant TRAF-3 mRNA species by RT-PCR that have the potential to encode novel isoforms, seven of which induce NF-kappaB activation when over-expressed in 293 cells. Here, their expression was characterized by RNAse protection assay, which showed the T cell line Jurkat D1.1 and the B cell lines BJAB, Daudi, and Raji each expressed mRNA encoding TRAF-3 splice-variants in approximately the same rank order (from highest to lowest); TRAF-3 Delta103aa, Delta83aa, full-length, Delta25aa, Delta52aa, Delta56aa, Delta27aa, and Delta221aa mRNA. The TRAF-3 Delta130aa mRNA was not detectable in any of the cell lines examined. The functional effect of over-expressing each TRAF-3 splice-variant on NF-kappaB activation was studied in the TRAF-5-responsive B cell line, BJAB. Of the seven TRAF-3 splice-variant isoforms that induce NF-kappaB activation in 293 cells, only TRAF-3 Delta27aa, Delta103aa, or Delta130aa induce NF-kappaB activation in BJAB cells. Together, these data indicate that a number of TRAF-3 splice-variant mRNAs are expressed and function in B and T lymphoma lines, which suggests that certain TRAF-3 splice-variant isoforms may participate in mediating the known functions of the TRAF-3 gene in lymphocytes.
Subject(s)
Alternative Splicing/immunology , Lymphoma, B-Cell/immunology , Lymphoma, B-Cell/metabolism , Lymphoma, T-Cell/immunology , Lymphoma, T-Cell/metabolism , Proteins/genetics , Gene Expression Regulation, Neoplastic/immunology , Genes, Reporter/immunology , Humans , Jurkat Cells , Lymphoma, B-Cell/genetics , Lymphoma, T-Cell/genetics , NF-kappa B/biosynthesis , NF-kappa B/genetics , NF-kappa B/metabolism , Protein Biosynthesis , Protein Isoforms/biosynthesis , Protein Isoforms/genetics , Protein Isoforms/physiology , Proteins/physiology , Ribonucleases/metabolism , Sequence Deletion/immunology , TNF Receptor-Associated Factor 3 , Transfection , Tumor Cells, CulturedABSTRACT
This article discusses the restoration of the endodontically-treated tooth as it relates to infrastructure and superstructure. Like any structure, it is only as sound as the base upon which it rests. The combination of endodontics and sophisticated developments in adhesive dentistry are considered in the attainment of predictable clinical success.
Subject(s)
Esthetics, Dental , Post and Core Technique , Root Canal Therapy , Adhesives , Cementation , Dental Prosthesis Design , Forecasting , Humans , Root Canal Filling Materials , Root Canal Therapy/instrumentation , Root Canal Therapy/methods , Surface Properties , Treatment OutcomeSubject(s)
Root Canal Therapy/methods , Biomechanical Phenomena , Dental Pulp Cavity/diagnostic imaging , Dental Pulp Diseases/diagnostic imaging , Dental Pulp Diseases/etiology , Dental Pulp Diseases/therapy , Humans , Patient Selection , Radiography , Recurrence , Retreatment , Risk Factors , Root Canal Therapy/adverse effects , Root Canal Therapy/instrumentation , Treatment FailureSubject(s)
Pain, Postoperative/etiology , Root Canal Therapy/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Cortisone/therapeutic use , Dexamethasone/therapeutic use , Humans , Pain, Postoperative/drug therapy , Pain, Postoperative/physiopathology , Pain, Postoperative/prevention & control , Periapical Periodontitis/drug therapy , Periapical Periodontitis/etiology , Root Canal Irrigants/therapeutic useABSTRACT
The emphasis in placing posts is shifting from their ability to strengthen the tooth structure to their capacity to provide additional retention and resistance to the displacement of the core material, without inducing undue installation or functional stresses. Numerous post systems are available. The learning objective of this article is to present a recently-introduced system of light-transmitting posts (LTP), with integrated size reamers and metal posts, which simplify the placement technique. A case report is used to illustrate the clinical procedure.
Subject(s)
Post and Core Technique/instrumentation , Child , Composite Resins , Humans , Incisor/injuries , Light , Male , Plastics , Root Canal Obturation/methods , Tooth Fractures/therapyABSTRACT
The flared canal, whether due to age, carious extension, pulpal pathology or endodontic access, presents a restorative management problem. Intra-radicular rehabilitation prior to post fabrication and/or cementation, increases the chance for operative success. This is the first in a series of articles that introduces the concept of esthetic considerations in post-endodontic restorative therapy.
Subject(s)
Endodontics/methods , Esthetics, Dental , Mouth Rehabilitation/methods , HumansABSTRACT
The primary objective of nonsurgical endodontic therapy is total debridement of the root canal system concomitant with three dimensional obturation of the entire intraradicular space recent supplements to the endodontic armamentarium have enhanced the predictability of clinical success by maximizing the potential for canal identification and by ensuring the maintenance of a closed, aseptic system during treatment. In addition, two systems have been introduced that facilitate retreatment of cases wherein biologic failure is occurring. One is used to remove solid core obturating materials that previously would have been considered inaccessible and the second enables disassembly of a previously restored endodontically treated tooth in order to access the deficiencies within the root canal system.
Subject(s)
Root Canal Therapy/instrumentation , Cellulose , Dental High-Speed Equipment , Foreign Bodies/therapy , Humans , Post and Core Technique , Rubber DamsABSTRACT
In the rat, perforations of maxillary molars were created and treated with either tricalcium phosphate (Synthograft) or Cavit. At four time intervals (1 day, 1 wk, 2 wk, and 1 month), four evaluative factors (inflammation, bone resorption, cementum and dentin resorption, and epithelial proliferation) were analyzed and compared for the two materials. For the individual time periods, there were no statistically significant differences between the two materials. However, when all four time periods were combined, there was a statistically significant better result for tricalcium phosphate than for Cavit with respect to decreased inflammation (p less than 0.05).