ABSTRACT
In an attempt to improve the diagnosis and to assess the intensity of intermittent cerebrospinal fluid rhinorrhea, indium-111 uptake by nasal pledgets during prolonged cisternography using 111In-DTPA was determined. In 12 patients having suspected cerebrospinal fluid rhinorrhea, cisternograms with calculation of counts/pixel in regions of interest were obtained, blood samples drawn, and nasal pledgets placed several times during 48 or 72 hr after lumbar intrathecal administration of 111In-DTPA. In three patients intermittent cerebrospinal fluid rhinorrhea was thus revealed; study by computed tomography was negative in each case. This procedure of extended radionuclide cisternography helped to detect, localize, and quantify intermittent cerebrospinal fluid rhinorrhea so that therapeutic decisions were facilitated and surgical intervention was minimized.
Subject(s)
Cerebrospinal Fluid Rhinorrhea/diagnostic imaging , Tomography, Emission-Computed/methods , Adolescent , Adult , Aged , Diagnosis, Differential , Female , Humans , Indium , Male , Pentetic Acid , RadioisotopesABSTRACT
In the serum of five patients with malignant germ cell tumor of the testis, prolactin as well as one or several of the gonadotropic, androgenic, estrogenic, and gestagenic hormones appeared to have the quality of tumor markers so that monitoring their serum level together with that of tissue polypeptide antigen, carcinoembryonic antigen, alpha-fetoprotein, and ferritin was useful. These compounds were determined by radioimmunoassay. Their serum concentration was often elevated although a constant pattern of findings or a relation to the severity of the disease was not observed. A corroboration of these results and an elucidation of their pathogenesis are necessary in a large number of patients.
Subject(s)
Gonadal Steroid Hormones/blood , Gonadotropins/blood , Neoplasms, Germ Cell and Embryonal/blood , Prolactin/blood , Testicular Neoplasms/blood , Adolescent , Adult , Androgens/blood , Estrogens/blood , Humans , Male , Middle Aged , Progestins/bloodSubject(s)
Hypersensitivity/diagnosis , Adolescent , Asthma/diagnosis , Child , Child, Preschool , Dermatitis, Contact/diagnosis , Dust , Female , Humans , Hypersensitivity/blood , Hypersensitivity/etiology , Immunoglobulin E/analysis , Male , Mites , Neurodermatitis/diagnosis , Radioallergosorbent Test , Rhinitis, Allergic, Seasonal/diagnosisSubject(s)
Adrenal Cortex Hormones/blood , C-Peptide/blood , Growth Hormone/blood , Hydrocortisone/blood , Insulin/blood , Peptides/blood , Running , Adolescent , Adult , Blood Glucose/analysis , Female , Hematocrit , Humans , Sports MedicineSubject(s)
Catecholamines/biosynthesis , Insulin/metabolism , Pheochromocytoma/metabolism , Adolescent , Adult , Blood Glucose , Female , Humans , Insulin Secretion , Male , Neuroblastoma/bloodABSTRACT
When bone marrow scintigraphy was performed using 111In-citrate, radioactivity was observed in the pudendal region. Subsequently, the kinetics of 111In in the pelvic region after intravenous administration of 111In-citrate for bone-marrow scanning in 14 patients was examined. On the first day, radioindium was found predominantly in the large pelvic blood vessels and in the pudendal region. In all male patients, the scrotal area was affected with both testes presumably delineated in two patients. In the female patients little radioindium was detected in the pudendal region, most probably in the vulva; distinct radioactivity was found in the pelvis although the ovaries could not be identified. In the following period the 111In uptake in the bone marrow increased considerably and reached its maximum usually 24 hr after the injection. Because a distinct radiation dose from 111In to the gonads cannot be excluded on the basis of our scintigraphic findings and the absorbed dose has not yet been estimated sufficiently, judgment should be used for the present if 111In-citrate is applied for bone marrow imaging.
Subject(s)
Bone Marrow , Citrates , Indium , Pelvis , Radioisotopes , Radionuclide Imaging , Adult , Bone Marrow/metabolism , Citrates/blood , Citrates/metabolism , Female , Humans , Male , Middle Aged , Penis/metabolism , Scrotum/metabolism , Testis/metabolism , Urinary Bladder/metabolism , Vulva/metabolismABSTRACT
Bone marrow scinitigraphy using 111In-Indium-citrate and 99mTc-sulfur rhenium colloid was compared with each other in 6 male and 3 female patients. Our results in all patients were in favour of 111In-citrate which caused a better delineation of morphological details than 99mTc-sulfur rhenium colloid did. In the first days after intravenous administration of 111In-citrate, radioindium accumulated markedly in the pudendal region, this finding being more distinct in male patients than in female ones. On account of these results a considerable radiation dose has to be assumed in bone marrow scinitigraphy using 111In-citrate as long as the absorbed dose from 111In has not been estimated under consideration of the radioindium accumulation in the pudendal region. 111In-citrate should be applied in bone marrow scanning only exceptionally and 99mTc-sulfur rhenium colloid be preferred in the routine diagnostics of bone marrow.
