[Methods of statistical analysis in differential diagnostics of the degree of brain glioma anaplasia during preoperative stage].

The authors proposed a possible preoperative diagnostics of the degree of supratentorial brain gliom anaplasia using statistical analysis methods. It relies on a complex examination of 934 patients with I-IV degree anaplasias, which had been treated in the Institute of Neurosurgery from 1990 to 2004. The use of statistical analysis methods for differential diagnostics of the degree of brain gliom anaplasia may optimize a diagnostic algorithm, increase reliability of obtained data and in some cases avoid carrying out irrational operative intrusions. Clinically important signs for the use of statistical analysis methods directed to preoperative diagnostics of brain gliom anaplasia have been defined

[Clinico-morphologic evaluation of susceptibility of glioblastoma to antiblastic therapy]. / Kliniko-morfologicheskaia otsenka chuvstvitelnosti glioblastomy k antiblasticheskoi terapii.

Pathomorphology of a cerebral glioblastoma in 82 patients was studied. The most pronounced regressive changes in the glioblastoma occurred under the influence of a complex of antiblastic treatment, including polychemo- and immunotherapy, radiation therapy. A high degree of damaging effect on a glioblastoma tissue correlated with the longest lifetime of the patients--(22.8 +/- 2.6) mos. Of these patients, 26% survived more than 24 mos, 17%--more than 36 mos. In patients with chemo-resistant glioblastoma which retains morphologically a stability of its histologic structure, the mean survival almost didn't differ from that in the control group. Only few patients survived more than 1 year.

[Efficacy of chemotherapy and immunochemotherapy in neuro-oncologic patients of various blood groups (ABO system)]. / Effektivnost' khimio- i immunokhimioterapii u neiroonkologicheskikh bol'nykh s razlichnoi gruppoi krovi (sistema ABO).

The efficacy of postoperative chemo- and immunochemotherapy was analysed according to the survival period from study of the catamnesis of patients who underwent operation for malignant (III-IV degree malignancy) gliomas. In analysing the efficacy of various schedules of combined treatment, the authors took into consideration the patients AB0 blood group because it is known that many antineoplastic antibiotics contain structures which are marked by cross reaction with the ABH isoantigens. The results of the study showed that the use of polychemotherapy and levamisole in neuro-oncological patients with A(II) and AB(IV) blood groups is promising. Levamisole and the antineoplastic antibiotic reumycin proved to be authentically effective in patients with A(II) blood group and ineffective in those with 0(I) blood group. The data obtained are recommended for use in individual selection of the schedule of chemo- and immunochemotherapy in patients with different AB0 blood group.

[Efficacy of experimental active specific immunotherapy and immunoprevention of malignant gliomas of the brain]. / Izuchenie éffektivnosti aktivnoi spetsificheskoi immunoterapii i immunoprofilaktiki zlokachestvennykh gliom golovnogo mozga v éksperimente.

The authors conducted experiments to study the efficacy of active specific immunotherapy and immunoprophylaxis with tumor cell lysate obtained by means of metabolites of Bac. mesentericus AB-56 in inoculated malignant glioma of the brain. Active immunotherapy was found to produce the best effect in the early latent period of tumor growth. It was less effective when tumor cells were inoculated in large doses and when the treatment was applied late. The investigated method of tumor cell inactivation was not used previously in neuro-oncology.