ABSTRACT
Recent clinical reports suggest that overexposure to light emissions generated from cathode ray tube (CRT) and liquid crystal display (LCD) color monitors after topical or systemic administration of a photosensitizer could cause noticeable skin phototoxicity. In this study, we examined the light emission profiles (optical irradiance, spectral irradiance) of CRT and LCD monitors under simulated movie and video game modes. Results suggest that peak emissions and integrated fluence generated from monitors are clinically relevant and therefore prolonged exposure to these light sources at a close distance should be avoided after the administration of a photosensitizer or phototoxic drug.
Subject(s)
Computer Terminals , Environmental Exposure/adverse effects , Photochemotherapy/adverse effects , Photosensitizing Agents/adverse effects , Radiometry , Skin Physiological Phenomena/drug effects , Skin Physiological Phenomena/radiation effects , Computer Simulation , Equipment Design , Equipment Failure Analysis , Humans , Liquid Crystals/chemistry , Models, Biological , Radiation Dosage , Risk AssessmentABSTRACT
We report on some of the optical properties of Hemoporfin (hematoporphyrin monomethyl ether, HMME), a photodynamic therapy (PDT) photosensitizer that has been in clinical trials in China since the early 1990s. We characterized the photosensitizer on the basis of one- and two-photon absorption and fluorescence emission. The effects of photobleaching were probed to characterize its decay kinetics. Additionally, we determined time resolved fluorescence and thermal effects on fluorescence and absorption properties.