ABSTRACT
A cDNA clone encoding bovine muscarinic acetylcholine m3 receptor has been isolated from a bovine brain library. Sequencing of this clone has revealed a single open reading frame encoding a protein of 590 amino acids. Comparison with known muscarinic m3 receptor sequences from other species shows a high degree of conservation (92-98% homology) in the protein sequence. COS cells transfected with this cDNA expressed a single high-affinity (Kd = 43.9 pM) binding site for muscarinic receptor ligand N-[3H]methylscopolamine.
Subject(s)
DNA, Complementary/genetics , Receptors, Muscarinic/genetics , Amino Acid Sequence , Animals , Base Sequence , Binding Sites , Cattle , Cloning, Molecular , DNA, Complementary/chemistry , Molecular Sequence Data , Receptors, Muscarinic/chemistry , Sequence Homology, Amino Acid , TransfectionABSTRACT
The history of smallpox is recounted through the eyes of those who bore witness to its terrors. A suggestion is made that the nursery rhyme, "A Ring Around the Rosie," may represent a depiction, in the old oral tradition of communication, of a smallpox epidemic.
Subject(s)
Disease Outbreaks/history , Folklore , Medicine in Literature , Smallpox/history , Asia , England , Europe , History, 17th Century , History, 18th Century , History, 19th Century , History, 20th Century , History, Medieval , Humans , Middle EastABSTRACT
This article traces the curious history of how psoriasis came to be called by its present appellation. In retelling the story, psoriasis is seen as a disease (known since antiquity) that has been confused with leprosy, with some tragic results.
Subject(s)
Leprosy/history , Psoriasis/history , Terminology as Topic , Bible , England , Greece , History, 19th Century , History, Ancient , History, Medieval , Humans , Leprosy/classification , Psoriasis/classification , Rome , United StatesABSTRACT
This paper recounts the history of the origin of the term syphilis and presents a partial translation of Fracastoro's poem, Syphilis, Sive Morbus Gallicus, wherein the word first appeared. The circumstances of the first known great epidemic of syphilis are told.
