Treatment planning for laser-accelerated very-high energy electrons.

In recent experiments, quasi-monoenergetic and well-collimated very-high energy electron (VHEE) beams were obtained by laser-plasma accelerators. We investigate their potential use for radiation therapy. Monte Carlo simulations are used to study the influence of the experimental characteristics such as beam energy, energy spread and initial angular distribution on the dose distributions. It is found that magnetic focusing of the electron beam improves the lateral penumbra. The dosimetric properties of the laser-accelerated VHEE beams are implemented in our inverse treatment planning system for intensity-modulated treatments. The influence of the beam characteristics on the quality of a prostate treatment plan is evaluated. In comparison to a clinically approved 6 MV IMRT photon plan, a better target coverage is achieved. The quality of the sparing of organs at risk is found to be dependent on the depth. The bladder and rectum are better protected due to the sharp lateral penumbra at low depths, whereas the femoral heads receive a larger dose because of the large scattering amplitude at larger depths.

Laser-driven plasma waves in capillary tubes.

The excitation of plasma waves over a length of up to 8 cm is demonstrated using laser guiding of intense laser pulses through hydrogen-filled glass capillary tubes. The plasma waves are diagnosed by spectral analysis of the transmitted laser radiation. The dependence of the spectral redshift-measured as a function of filling pressure, capillary tube length, and incident laser energy-is in excellent agreement with simulation results. The longitudinal accelerating field inferred from the simulations is in the range of 1-10 GV/m.

High flux of relativistic electrons produced in femtosecond laser-thin foil target interactions: characterization with nuclear techniques.

We present a protocol to characterize the high energy electron beam emitted in the interaction of an ultraintense laser with matter at intensities higher than 10(19) W cm(-2). The electron energies and angular distributions are determined as well as the total number of electrons produced above a 10 MeV threshold. This protocol is based on measurements with an electron spectrometer and nuclear activation techniques, combined with Monte Carlo simulations based on the GEANT3 code. The method is detailed and exemplified with data obtained with polypropylene and copper thin solid targets at a laser intensity of 2x10(19) W cm(-2). Special care is taken of the different sources of uncertainties. In particular, the reproducibility of the laser shots is considered.

Observation of fine structures in laser-driven electron beams using coherent transition radiation.

We have measured the coherent optical transition radiation emitted by an electron beam from laser-plasma interaction. The measurement of the spectrum of the radiation reveals fine structures of the electron beam in the range 400-1000 nm. These structures are reproduced using an electron distribution from a 3D particle-in-cell simulation and are attributed to microbunching of the electron bunch due to its interaction with the laser field. When the radiator is placed closer to the interaction point, spectral oscillations have also been recorded, signature of the interference of the radiation produced by two electron bunches delayed by 74 fs. The second electron bunch duration is shown to be ultrashort to match the intensity level of the radiation. Whereas transition radiation was used at longer wavelengths in order to estimate the electron bunch length, this study focuses on the ultrashort structures of the electron beam.

Controlled injection and acceleration of electrons in plasma wakefields by colliding laser pulses.

In laser-plasma-based accelerators, an intense laser pulse drives a large electric field (the wakefield) which accelerates particles to high energies in distances much shorter than in conventional accelerators. These high acceleration gradients, of a few hundreds of gigavolts per metre, hold the promise of compact high-energy particle accelerators. Recently, several experiments have shown that laser-plasma accelerators can produce high-quality electron beams, with quasi-monoenergetic energy distributions at the 100 MeV level. However, these beams do not have the stability and reproducibility that are required for applications. This is because the mechanism responsible for injecting electrons into the wakefield is based on highly nonlinear phenomena, and is therefore hard to control. Here we demonstrate that the injection and subsequent acceleration of electrons can be controlled by using a second laser pulse. The collision of the two laser pulses provides a pre-acceleration stage which provokes the injection of electrons into the wakefield. The experimental results show that the electron beams obtained in this manner are collimated (5 mrad divergence), monoenergetic (with energy spread <10 per cent), tuneable (between 15 and 250 MeV) and, most importantly, stable. In addition, the experimental observations are compatible with electron bunch durations shorter than 10 fs. We anticipate that this stable and compact electron source will have a strong impact on applications requiring short bunches, such as the femtolysis of water, or high stability, such as radiotherapy with high-energy electrons or radiography for materials science.

Radiotherapy with laser-plasma accelerators: Monte Carlo simulation of dose deposited by an experimental quasimonoenergetic electron beam.

The most recent experimental results obtained with laser-plasma accelerators are applied to radio-therapy simulations. The narrow electron beam, produced during the interaction of the laser with the gas jet, has a high charge (0.5 nC) and is quasimonoenergetic (170 +/- 20 MeV). The dose deposition is calculated in a water phantom placed at different distances from the diverging electron source. We show that, using magnetic fields to refocus the electron beam inside the water phantom, the transverse penumbra is improved. This electron beam is well suited for delivering a high dose peaked on the propagation axis, a sharp and narrow tranverse penumbra combined with a deep penetration.

Laser-plasma accelerator: status and perspectives.

Laser-plasma accelerators deliver high-charge quasi-monoenergetic electron beams with properties of interest for many applications. Their angular divergence, limited to a few mrad, permits one to generate a small gamma ray source for dense matter radiography, whereas their duration (few tens of fs) permits studies of major importance in the context of fast chemistry for example. In addition, injecting these electron beams into a longer plasma wave structure will extend their energy to the GeV range. A GeV laser-based accelerator scheme is presented; it consists of the acceleration of this electron beam into relativistic plasma waves driven by a laser. This compact approach (centimetres scale for the plasma, and tens of meters for the whole facility) will allow a miniaturization and cost reduction of future accelerators and derived X-ray free electron laser (XFEL) sources.

Observation of laser-pulse shortening in nonlinear plasma waves.

We have measured the temporal shortening of an ultraintense laser pulse interacting with an underdense plasma. When interacting with strongly nonlinear plasma waves, the laser pulse is shortened from 38 +/- 2 fs to the 10-14 fs level, with a 20% energy efficiency. The laser ponderomotive force excites a wakefield, which, along with relativistic self-phase modulation, broadens the laser spectrum and subsequently compresses the pulse. This mechanism is confirmed by 3D particle in cell simulations.

High-resolution gamma-ray radiography produced by a laser-plasma driven electron source.

An electron beam from a laser-plasma accelerator is converted into a gamma-ray source using bremsstrahlung radiation in a dense material. The gamma-ray beam has a pointlike source size because it is generated by a high quality electron beam with a small source size and a low divergence. Using this gamma-ray source, the radiography of complex and dense objects with submillimeter resolution is performed. It is the first evidence of a gamma-ray source size of a few hundreds micrometers produced with laser-driven accelerators. This size is consistent with results from Monte Carlo simulations.

A laser-plasma accelerator producing monoenergetic electron beams.

Particle accelerators are used in a wide variety of fields, ranging from medicine and biology to high-energy physics. The accelerating fields in conventional accelerators are limited to a few tens of MeV m(-1), owing to material breakdown at the walls of the structure. Thus, the production of energetic particle beams currently requires large-scale accelerators and expensive infrastructures. Laser-plasma accelerators have been proposed as a next generation of compact accelerators because of the huge electric fields they can sustain (>100 GeV m(-1)). However, it has been difficult to use them efficiently for applications because they have produced poor-quality particle beams with large energy spreads, owing to a randomization of electrons in phase space. Here we demonstrate that this randomization can be suppressed and that the quality of the electron beams can be dramatically enhanced. Within a length of 3 mm, the laser drives a plasma bubble that traps and accelerates plasma electrons. The resulting electron beam is extremely collimated and quasi-monoenergetic, with a high charge of 0.5 nC at 170 MeV.