ABSTRACT
We present an unusual tumorous variety of scleromyxedema mimicking facies leonina in lymphoma. In spite of pronounced and widespread cutaneous changes, hypergammaglobulinaemia and paraproteinaemia, the general condition of the patient was satisfactory, there was no internal involvement and no symptoms of any malignancy. Initially, melphalan and corticosteroids were applied but were not effective. High-dose intravenous immunoglobulin (IVIG) therapy had dramatic effect, and after five 5-day monthly courses the tumours almost regressed and the skin became less hard. After a further five courses in the following year there was complete clearance, which was sustained without any therapy for 1 year (until now). IVIG appears to be the therapy of choice for scleromyxedema. We stress, however, that at the start of therapy, IVIG applications should be supplemented with small doses of melphalan and/or corticosteroids.
Subject(s)
Facial Dermatoses/diagnosis , Facial Dermatoses/drug therapy , Immunoglobulins, Intravenous/administration & dosage , Myxedema/diagnosis , Myxedema/drug therapy , Diagnosis, Differential , Facial Dermatoses/pathology , Female , Humans , Middle Aged , Myxedema/pathologySubject(s)
Lip Diseases/drug therapy , Pyoderma/drug therapy , Adult , Female , Humans , Male , Middle Aged , Sulfonamides/therapeutic useSubject(s)
B-Lymphocytes/immunology , Lymphocyte Activation , Skin Diseases/immunology , T-Lymphocytes/immunology , Carcinoma, Squamous Cell/immunology , Dermatitis, Contact/immunology , Humans , Lupus Erythematosus, Discoid/immunology , Prurigo/immunology , Rosette Formation , Skin Neoplasms/immunologyABSTRACT
The results of cerebrospinal fluid examination of 451 patients treated for syphilis were analysed. In 34 patients abnormalities were found in the protein level, cell number and serological investigations. Thus, there is an absolute indication to cerebrospinal fluid examination in each case in which serological tests remain positive despite adequate specific therapy.