ABSTRACT
BACKGROUND: The idiopathic hypereosinophilic syndrome is a rare systemic disease characterized by blood and tissue eosinophilia of unknown etiology, in which multiple organs may be affected. In hypereosinophilic dermatitis the only affected organ besides the blood is the skin. PATIENTS: We present a series of seven patients with hypereosinophilic dermatitis who were treated in our hospital between 2002 and 2003. RESULTS: All patients initially showed characteristic, therapy-resistant, polymorphic skin lesions, presenting with a combination of erythematous, pruritic and urticarial papules and plaques. All had blood eosinophilia without evidence of allergic, parasitic or other causes. The histology showed tissue eosinophilia only in half of the cases; the other histological findings were non-specific. We observed a good response to therapy with systemic corticosteroids, dapsone and light therapy, applied as UVA-1 irradiation or as shower photochemotherapy. CONCLUSIONS: The diagnosis "hypereosinophilic dermatitis" should be based primarily on the characteristic clinical picture together with "idiopathic" peripheral eosinophilia, whereas the histological findings are not always indicative. Because of the multiplicity of possible differential diagnoses and the often non-revealing histology, we assume that the diagnosis "hypereosinophilic dermatitis" is often overlooked.
Subject(s)
Dermatitis/diagnosis , Dermatitis/therapy , Hypereosinophilic Syndrome/diagnosis , Hypereosinophilic Syndrome/therapy , Adult , Aged , Dermatitis/classification , Diagnosis, Differential , Female , Humans , Hypereosinophilic Syndrome/classification , Male , Middle AgedSubject(s)
Anticoagulants/adverse effects , Dalteparin/adverse effects , Fibrinolytic Agents/adverse effects , Purpura/diagnosis , Skin Diseases/chemically induced , Skin Diseases/diagnosis , Skin/pathology , Aged , Aged, 80 and over , Diagnosis, Differential , Extremities , Female , Humans , Necrosis , Purpura/chemically induced , Skin Diseases/pathologyABSTRACT
Soft X-Ray (Dermopan) is an effective and gentle treatment for large basal cell carcinomas of the face. It is an useful alternative to extensive and often cosmetically unsatisfactory surgery, especially in large basal cell carcinomas covering an area of more than 4 cm2. A 79-year-old man presented with a 4,5-year history of an extensive basal cell carcinoma on the right temple, which was treated by soft x-ray after removal of excessive tumor tissue with electrocautery. A total dosage of 48 Gy was employed.
