ABSTRACT
A rapid and versatile method for the preparation of planar chiral [2.2]paracyclophane-derived pyridines and pyridine N-oxides is reported. The potential utility of these compounds in Lewis base catalysis is briefly introduced.
Subject(s)
Lewis Bases/chemistry , Oxides/chemical synthesis , Catalysis , Molecular Structure , Oxides/chemistry , Polycyclic Compounds/chemistry , Pyridines/chemistry , StereoisomerismABSTRACT
Two planar chiral heteroaryl monophosphines have been synthesised and studied. The phosphines are readily prepared from 4-imidazole[2.2]paracyclophane by selective deprotonation and reaction with the appropriate dialkylchlorophosphines. The planar chiral imidazole was constructed in four steps from readily available [2.2]paracyclophane. The 2-phosphino-N-[2.2]paracyclophanes were active in the Suzuki-Miyaura coupling of aryl bromides and chlorides. Coordination studies indicate P,N-chelation in the solid-state. These studies lay the foundations for asymmetric couplings.
ABSTRACT
Hip protectors have been shown to be effective in reducing the incidence of hip fracture among older people living in care homes (Parker et al, 2004). However, there are problems with compliance. This article reports findings from a survey of 138 staff from 23 care homes about experiences and perceptions of using hip protectors. The survey was complemented by qualitative case studies involving staff, to be linked to compliance with wearing hip protectors including comfort, acceptability to the resident and appearance. Few practical difficulties in using hip protectors were identified. Staff and residents' perceptions and experiences of using hip protectors vary and are likely to influence compliance.
Subject(s)
Aged/psychology , Attitude of Health Personnel , Attitude to Health , Hip Fractures/prevention & control , Nursing Homes , Protective Devices/standards , Accidental Falls/prevention & control , Adolescent , Adult , England , Female , Focus Groups , Geriatric Assessment , Geriatric Nursing , Hip Fractures/epidemiology , Hip Fractures/etiology , Humans , Incidence , Male , Middle Aged , Nurse's Role , Nursing Methodology Research , Nursing Staff/education , Nursing Staff/psychology , Qualitative Research , Surveys and QuestionnairesABSTRACT
This article is the second of a two-part series based upon a research project to evaluate the impact of a specialist nurse role in reducing the incidence of hip fracture within care homes. The first article (Vol 13 (21): 1242-48) described the background and methods of the study, and presented the findings relating to resident and staff experiences of using hip protectors as a preventive measure within the homes. This article focuses on staff experiences of hip fracture prevention strategies and implementing evidence-based practice in this area. Findings suggest that specialist nurses have the potential to encourage evidence-based practice within care homes, while also improving staff morale and job satisfaction.
