ABSTRACT
In order to increase the effectiveness of treatment of the liver cirrhosis were examined 65 patients, we studied the effect on the features flow of intestine microbiocenosis and were are included to the combined treatment the synbiotic medications "Bifilakt extra". Inclusion to the combined treatment of the examined patients with liver cirrhosis synbiotic medications "Bifilakt extra" probably led to better reduction of subjective and objective signs of cirrhosis and intensity of functional biochemical syndromes, symptoms of hepatic encephalopathy.
Subject(s)
Dysbiosis/drug therapy , Intestinal Diseases/drug therapy , Liver Cirrhosis/drug therapy , Synbiotics/administration & dosage , Alcoholism/complications , Drug Therapy, Combination , Dysbiosis/complications , Dysbiosis/microbiology , Feces/microbiology , Female , Hepatitis B/complications , Hepatitis C/complications , Humans , Intestinal Diseases/complications , Intestinal Diseases/microbiology , Liver Cirrhosis/etiology , Liver Cirrhosis/microbiology , Liver Cirrhosis, Alcoholic/drug therapy , Liver Cirrhosis, Alcoholic/etiology , Liver Cirrhosis, Alcoholic/microbiology , Liver Function Tests , Male , Middle AgedABSTRACT
Monocytic production of peripheral blood thromboxane B2 and leukotriene B4, levels of cAMP and total lipids in these cells were examined in 58 patients with stable angina induced by exercise and 32 healthy donors. There was a hyperproduction of thromboxane B2 and leukotriene B4 by monocytes in the patients, a decrease in cAMP levels, and lipid accumulation in these cells in effort angina. The calcium antagonists verapamil and nifedipine abolished the above impairments. The author suggests that calcium antagonists should be regarded as a new class of antiathero-sclerotic agents that have effects predominantly on the cellular link of atherogenesis.
Subject(s)
Calcium Channel Blockers/pharmacology , Coronary Disease/drug therapy , Monocytes/drug effects , Angina Pectoris/drug therapy , Calcium Channel Blockers/therapeutic use , Coronary Disease/blood , Cyclic AMP/blood , Humans , In Vitro Techniques , Leukotriene B4/blood , Lipids/blood , Monocytes/metabolism , Nifedipine/pharmacology , Nifedipine/therapeutic use , Thromboxane B2/blood , Verapamil/pharmacology , Verapamil/therapeutic useABSTRACT
Examination of the effect of calcium antagonists on the functional activity of monocytes revealed the possibility of using these cells as an object for testing antiatherosclerotic agents. The functional activity of monocytes was evaluated by their capacity of producing thromboxane B2 and by the cellular content of cyclic AMP. It is suggested that calcium antagonists verapamil and niphedipin, in particular, are potential antiatherosclerotic agents.
